4.0
Summary
| Name |  RNMTView Modifications |
| Full Name | mRNA cap guanine-N7 methyltransferase |
| Synonyms | RG7MT1, mRNA (guanine-N(7))-methyltransferase, mRNA cap methyltransferase, hCMT1, hMet, hcm1p | KIAA0398 |
| Primary ID | O43148 |
| Links |  -  -  |
| Type | protein |
| Relations | 5 |
| Pathways | mRNA maturation |
| Function | Catalytic subunit of the mRNA-capping methyltransferase RNMT:RAMAC complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs (PubMed:9790902, PubMed:9705270, PubMed:10347220, PubMed:11114884, PubMed:22099306, PubMed:27422871). Binds RNA containing 5'-terminal GpppC (PubMed:11114884). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CDK1 | up-regulates activity 
phosphorylation
|
RNMT | 0.255 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RNMT | up-regulates quantity
chemical modification
|
messenger RNA | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | mRNA maturation, mRNA maturation | |||
| + | KPNA2 | down-regulates activity 
binding
|
RNMT | 0.412 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RAMAC | up-regulates activity
binding
|
RNMT | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | mRNA maturation, mRNA maturation | |||
| + | RNMT | up-regulates 
|
mRNA_capping | 0.7 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | mRNA maturation, mRNA maturation | |||