3.0
Summary
| Name |  DYRK3View Modifications |
| Full Name | Dual specificity tyrosine-phosphorylation-regulated kinase 3 |
| Synonyms | Regulatory erythroid kinase, REDK |
| Primary ID | O43781 |
| Links |  -  -  |
| Type | protein |
| Relations | 6 |
| Function | Dual-specificity protein kinase that promotes disassembly of several types of membraneless organelles during mitosis, such as stress granules, nuclear speckles and pericentriolar material (PubMed:29973724). Dual-specificity tyrosine-regulated kinases (DYRKs) autophosphorylate a critical tyrosine residue in their activation loop and phosphorylate their substrate on serine and threonine residues (PubMed:9748265, PubMed:29634919). Acts as a central dissolvase of membraneless organelles during the G2-to-M transition, after the nuclear-envelope breakdown |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | DYRK3 | down-regulates activity 
phosphorylation
|
NCOA3 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | DYRK3 | down-regulates activity
phosphorylation
|
AKT1S1 | 0.339 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ATF4 | down-regulates quantity by repression
transcriptional regulation
|
DYRK3 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | DYRK3 | down-regulates
phosphorylation
|
mTORC1 | 0.288 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | DYRK3 | up-regulates activity 
phosphorylation
|
SIRT1 | 0.503 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | DYRK3 | down-regulates
phosphorylation
|
AKT1S1 | 0.339 |
| Publications: | 1 | Organism: | Homo Sapiens | |