| + |
ADAM10 | up-regulates activity 
cleavage
|
EGF |
0.549 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259840 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26284334 |
Like ADAM17, ADAM10 has also been implicated in the activation of specific EGFR ligands, especially EGF and betacellulin |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EGF | up-regulates
binding
|
EGFR |
0.948 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-22716 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12648462 |
The mammalian ligands that bind the egf receptor (egfr [her1, erb-b1]) include egf, transforming growth factor- (tgf), heparin-binding egf-like growth factor (hb-egf), amphiregulin (ar), betacellulin (btc), epiregulin (epr), and epigen |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, EGFR Signaling, Glioblastoma Multiforme, Non-small-cell lung cancer (NSCLC), Pancreatic ductal adenocarcinoma (PDA), PI3K/AKT Signaling, SARS-CoV MAPK PERTURBATION |
| + |
EGF | up-regulates
binding
|
ERBB2 |
0.784 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-106497 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11279155 |
To better understand the role of the egfr tyrosine kinase, we analyzed signaling by a kinase-inactive egfr (k721m) in erbb-devoid 32d cells. K721m alone exhibited no detectable signaling capacity, whereas coexpression of k721m with erbb2, but not erbb3 or erbb4, resulted in egf-dependent mitogen-activated protein kinase (mapk) activation. The kinase activity, but not tyrosine phosphorylation, of erbb2 was required for egf-induced mapk activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EGF | up-regulates quantity by expression 
transcriptional regulation
|
HBB |
0.263 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251782 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 9168989 |
We describe the roles of Stat5 and of these tyrosine residues in the EPOR in the erythroid differentiation of murine hematopoietic cell line SKT6 which produces hemoglobin in response to EPO. Chimeric receptors carrying the extracellular domain of the EGF receptor and the intracellular domain of the EPOR were introduced into SKT6 cells. Like EPO, EGF equally activated Stat5 and induced hemoglobin. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
EGF | up-regulates quantity by expression
transcriptional regulation
|
HBA1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251785 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 9168989 |
We describe the roles of Stat5 and of these tyrosine residues in the EPOR in the erythroid differentiation of murine hematopoietic cell line SKT6 which produces hemoglobin in response to EPO. Chimeric receptors carrying the extracellular domain of the EGF receptor and the intracellular domain of the EPOR were introduced into SKT6 cells. Like EPO, EGF equally activated Stat5 and induced hemoglobin. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
SLC34A2 | down-regulates 
|
EGF |
0.36 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-105161 |
|
|
Homo sapiens |
CACO-2 Cell |
| pmid |
sentence |
| 11171583 |
In vivo and in vitro studies showed that egf treatment decreased intestinal napi-iib mrna abundance by _50%, suggesting possible transcriptional regulation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Lung |
| + |
EGF | up-regulates activity
binding
|
EGFR |
0.948 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-186159 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12297050 |
Epidermal growth factor (egf) regulates cell proliferation and differentiation by binding to the egf receptor (egfr) extracellular region, comprising domains i-iv, with the resultant dimerization of the receptor tyrosine kinase. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, EGFR Signaling, Glioblastoma Multiforme, Non-small-cell lung cancer (NSCLC), Pancreatic ductal adenocarcinoma (PDA), PI3K/AKT Signaling, SARS-CoV MAPK PERTURBATION |
3.0
EGF
- 
- 