Summary

Name SERPINE1
Full Name Plasminogen activator inhibitor 1
Synonyms PAI, PAI-1, Endothelial plasminogen activator inhibitor, Serpin E1 | PAI1, PLANH1
Primary ID P05121
Links - -
Type protein
Relations 12
Pathways Circadian clock, COVID-19 Causal Network, Fibrosis, SARS-CoV FIBROSIS
Function Serine protease inhibitor. Inhibits TMPRSS7 (PubMed:15853774). Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots (PubMed:8481516, PubMed:9207454, PubMed:17912461). As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading (PubMed:9175705). Acts as a regulator of cell migration, independently of its role as protease inhibitor (PubMed:15001579, PubMed:9168821). It is required for stimulation of keratinocyte migration during cutaneous injury repair (PubMed:18386027). It is involved in cellular and replicative senescence (PubMed:16862142). Plays a role in alveolar type 2 cells senescence in the lung (By similarity). Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis (PubMed:25808697, PubMed:27046084).

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Relations

Regulator Mechanism target score
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation SERPINE1 0.269
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SERPINE1 0.434
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png Fibrinolysis 0.7
Publications: 2 Organism: Homo Sapiens
Pathways:Circadian clock
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SERPINE1 0.45
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Fibrosis, SARS-CoV FIBROSIS
+ up-regulates img/indirect-activation.png Fibrosis 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Fibrosis, SARS-CoV FIBROSIS
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation SERPINE1 0.495
Publications: 1 Organism: Homo Sapiens
Pathways:Circadian clock
+ up-regulates img/indirect-activation.png Cell_adhesion 0.7
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SERPINE1 0.574
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Fibrosis, SARS-CoV FIBROSIS
+ down-regulates activity img/direct_inhibition.png binding F12 0.312
Publications: 1 Organism: Homo Sapiens
Tissue: Blood Plasma
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation SERPINE1 0.504
Publications: 1 Organism: Homo Sapiens
Pathways:Circadian clock
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SERPINE1 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV FIBROSIS