| + |
CSNK2A1 | down-regulates activity 
phosphorylation
|
MYB |
0.346 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250918 |
Ser11 |
RPRHSIYsSDEDDED |
in vitro |
|
| pmid |
sentence |
| 7735324 |
For c-Myb mutational analysis of the CKII phosphorylation sites showed altered steady state DNA binding. Replacing Ser-11/12 by alanine residues resulted in increased DNA binding compared to wt c-Myb or Myb Asp-11/12 as demonstrated by up to 10-fold differences in the dissociation constants. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250919 |
Ser12 |
PRHSIYSsDEDDEDF |
in vitro |
|
| pmid |
sentence |
| 7735324 |
For c-Myb mutational analysis of the CKII phosphorylation sites showed altered steady state DNA binding. Replacing Ser-11/12 by alanine residues resulted in increased DNA binding compared to wt c-Myb or Myb Asp-11/12 as demonstrated by up to 10-fold differences in the dissociation constants. |
|
| Publications: |
2 |
Organism: |
In Vitro |
| + |
MAPK1 |
phosphorylation
|
MYB |
0.492 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249420 |
Ser532 |
KIKQEVEsPTDKSGN |
in vitro |
|
| pmid |
sentence |
| 8960373 |
Functional analysis of phosphorylation at serine 532 of human c-Myb by MAP kinase| Expression of a constitutively active form of Ras together with c-Myb in transient transfection experiments had no effect on the transcriptional activity of c-Myb, while expression of a polypeptide containing the c-Myb C-terminal domain stimulated c-Myb activity. This effect is reduced upon MAPK-dependent phosphorylation of serine 532. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
MAPK3 | down-regulates
phosphorylation
|
MYB |
0.306 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-43558 |
Ser532 |
KIKQEVEsPTDKSGN |
Homo sapiens |
|
| pmid |
sentence |
| 8798443 |
Here we describe that human c-myb can be phosphorylated by mitogen-activated protein kinases (mapk's) at serine 532 of the carboxy (c-) terminal regulatory domain in vitro. expression of a constitutively active form of ras together with c-myb in transient transfection experiments had no effect on the transcriptional activity of c-myb, while expression of a polypeptide containing the c-myb c-terminal domain stimulated c-myb activity. This effect is reduced upon mapk-dependent phosphorylation of serine 532. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-45348 |
Ser532 |
KIKQEVEsPTDKSGN |
Homo sapiens |
JURKAT Cell |
| pmid |
sentence |
| 8960373 |
Functional analysis of phosphorylation at serine 532 of human c-myb by map kinase. expression of a polypeptide containing the c-myb c-terminal domain stimulated c-myb activity. This effect is reduced upon mapk-dependent phosphorylation of serine 532. Our data suggest that the mapk-dependent state of phosphorylation modifies the cellular function of c-myb by modulating its interaction with a putative inhibitory factor |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
ERK1/2 | down-regulates
phosphorylation
|
MYB |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-244569 |
Ser532 |
KIKQEVEsPTDKSGN |
Homo sapiens |
JURKAT Cell |
| pmid |
sentence |
| 8960373 |
Functional analysis of phosphorylation at serine 532 of human c-myb by map kinase. expression of a polypeptide containing the c-myb c-terminal domain stimulated c-myb activity. This effect is reduced upon mapk-dependent phosphorylation of serine 532. Our data suggest that the mapk-dependent state of phosphorylation modifies the cellular function of c-myb by modulating its interaction with a putative inhibitory factor |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NCL | down-regulates activity
binding
|
MYB |
0.41 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-221236 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 10660576 |
We identify nucleolin as one of the nuclear polypeptides that interact specifically with the A-Myb and c-Myb. We show that the interaction of nucleolin with Myb is functional because co-transfection of nucleolin down-regulates Myb transcriptional activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Gbeta | down-regulates
phosphorylation
|
MYB |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270089 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8798443 |
Here we describe that human c-myb can be phosphorylated by mitogen-activated protein kinases (mapk's) at serine 532 of the carboxy (c-) terminal regulatory domain in vitro. expression of a constitutively active form of ras together with c-myb in transient transfection experiments had no effect on the transcriptional activity of c-myb, while expression of a polypeptide containing the c-myb c-terminal domain stimulated c-myb activity. This effect is reduced upon mapk-dependent phosphorylation of serine 532. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SATB1 | down-regulates quantity by repression 
transcriptional regulation
|
MYB |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255135 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17343824 |
We found 59 up-regulated and 75 down-regulated genes in the K562-SATB1 cells that were not observed in the K562 cells. Partial genes that have special biological functions are listed in Table 1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MYB | up-regulates quantity by expression 
transcriptional regulation
|
GSTM1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253975 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 14576818 |
Functional analysis of the GSTM1 promoter using reporter assays indicated that both the DNA binding and transactivation domains of Myb were required for transcriptional activation |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
TWIST1 | down-regulates quantity by repression
transcriptional regulation
|
MYB |
0.249 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255529 |
|
|
Homo sapiens |
HGC-27 Cell |
| pmid |
sentence |
| 19051271 |
we performed microarray analysis to compare the gene expression profiles in HGC-27 cells, with or without small interfering RNA (siRNA)-mediated depletion of TWIST. Our results showed that NF1, RAP1A, SRPX, RBL2, PFDN4, ILK, F2R, ERBB3, and MYB were up-regulated, whereas AKR1C2, FOS, GDF15, NR2F1, ATM, and CTPS were down-regulated after TWIST depletion |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TWIST2 | down-regulates quantity by repression
transcriptional regulation
|
MYB |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255495 |
|
|
Homo sapiens |
HGC-27 Cell |
| pmid |
sentence |
| 19051271 |
we performed microarray analysis to compare the gene expression profiles in HGC-27 cells, with or without small interfering RNA (siRNA)-mediated depletion of TWIST. Our results showed that NF1, RAP1A, SRPX, RBL2, PFDN4, ILK, F2R, ERBB3, and MYB were up-regulated, whereas AKR1C2, FOS, GDF15, NR2F1, ATM, and CTPS were down-regulated after TWIST depletion |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CREBBP | up-regulates activity
binding
|
MYB |
0.798 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-240994 |
|
|
Chlorocebus aethiops |
COS Cell |
| pmid |
sentence |
| 8654374 |
the nuclear co-activator CREB binding protein (CBP). This protein interacts directly with both c-Myb and v-Myb and potentiates Myb-specific transcription |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
MAF | down-regulates
binding
|
MYB |
0.645 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-56811 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9566892 |
Full-length c-maf binds to the c-myb and ets-1. / c-maf inhibits c-myb and ets-1 transcriptional activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ARID5B | up-regulates quantity by expression 
transcriptional regulation
|
MYB |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256160 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 29326336 |
We also observed that ARID5B regulates the expression of four major components of the TAL1 complex (namely, TAL1,GATA3, RUNX1, and MYB) in Jurkat cells. Knockdown of ARID5B resulted in reductions of the H3K27ac signals at those enhancer loci (Supplemental Fig. S6E–H) and down-regulation of all four factors at the mRNA (Fig. 6E) and protein levels (Fig. 6F). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PML-RARalpha | up-regulates quantity
transcriptional regulation
|
MYB |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259939 |
|
|
Homo sapiens |
Promyelocyte |
| pmid |
sentence |
| 30335887 |
PML/RARa blocks the differentiation and promotes the proliferation of acute promyelocytic leukemia through activating MYB expression by transcriptional and epigenetic regulation mechanisms. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
MYB
- 
- 