Summary

Name RAB5A
Full Name Ras-related protein Rab-5A
Synonyms RAB5A_HUMAN | RAB5
Primary ID P20339
Links - -
Type protein
Relations 10
Function Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes (PubMed:10818110, PubMed:14617813, PubMed:16410077, PubMed:15378032). Contributes to the regulation of filopodia extension (PubMed:14978216). Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan (PubMed:22660413). Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3 (By similarity).

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Relations

Regulator Mechanism target score ℹ
+ RAB5Aup-regulates activity img/direct-activation.png binding COMMD5 0.2
Publications: 1 Organism: Homo Sapiens
+ LYSTdown-regulates activity img/direct_inhibition.png binding RAB5A 0.271
Publications: 1 Organism: Drosophila Melanogaster
+ RAB5Aup-regulates activity img/direct-activation.png binding PIK3R4 0.438
Publications: 1 Organism: Mus Musculus
+ RAB5Aform complex img/form-complex.png binding Early Endosome 0.531
Publications: 1 Organism: Homo Sapiens
+ RABGEF1up-regulates img/direct-activation.png binding RAB5A 0.92
Publications: 1 Organism: Homo Sapiens
+ RABEP1up-regulates img/direct-activation.png binding RAB5A 0.927
Publications: 1 Organism: Homo Sapiens
+ SUN2up-regulates activity img/direct-activation.png binding RAB5A 0.43
Publications: 1 Organism: Homo Sapiens
+ RABGEF1up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RAB5A 0.92
Publications: 1 Organism: Mus Musculus
+ RABGGTBup-regulates activity img/direct-activation.png lipidation RAB5A 0.462
Publications: 1 Organism: Homo Sapiens
+ RABGGTAup-regulates activity img/direct-activation.png lipidation RAB5A 0.601
Publications: 1 Organism: Homo Sapiens