| + |
PRKCD | up-regulates activity 
phosphorylation
|
SDC4 |
0.506 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-116265 |
Ser179 |
MKKKDEGsYDLGKKP |
Rattus norvegicus |
|
| pmid |
sentence |
| 11916978 |
The phosphorylation state of Ser(183) in the cytoplasmic tail of syndecan-4 determines the binding affinity of the cytoplasmic tail to phosphatidylinositol 4,5-bisphosphate (PIP(2)), the capacity of the tail to multimerize, and its ability to activate protein kinase C (PKC) alpha. We sought to identify the kinase responsible for this phosphorylation and to determine its downstream effects on PKCalpha activity and on endothelial cell function. Among several PKC isoenzymes tested, only PKCalpha and -delta were able to specifically phosphorylate Ser(183) in vitro. However, studies in cultured endothelial cells showed that the phosphorylation level of syndecan-4 was significantly reduced in endothelial cells expressing a dominant negative (DN) PKCdelta but not a DN PKCalpha mutant. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
PRKCA | up-regulates activity
phosphorylation
|
SDC4 |
0.722 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249149 |
Ser179 |
MKKKDEGsYDLGKKP |
Rattus norvegicus |
Endothelial Cell |
| pmid |
sentence |
| 11916978 |
The phosphorylation state of Ser(183) in the cytoplasmic tail of syndecan-4 determines the binding affinity of the cytoplasmic tail to phosphatidylinositol 4,5-bisphosphate (PIP(2)), the capacity of the tail to multimerize, and its ability to activate protein kinase C (PKC) alpha. We sought to identify the kinase responsible for this phosphorylation and to determine its downstream effects on PKCalpha activity and on endothelial cell function. Among several PKC isoenzymes tested, only PKCalpha and -delta were able to specifically phosphorylate Ser(183) in vitro. However, studies in cultured endothelial cells showed that the phosphorylation level of syndecan-4 was significantly reduced in endothelial cells expressing a dominant negative (DN) PKCdelta but not a DN PKCalpha mutant. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
SDC4 | form complex 
binding
|
FN1/SDC4 |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255286 |
|
|
|
|
| pmid |
sentence |
| 23290138 |
We found that binding of ECM glycoprotein Fibronectin (FN) to Sdc4 stimulates the ability of Wnt7a to induce the symmetric expansion of satellite stem cells |
|
| Publications: |
1 |
| + |
SDC4 | up-regulates
binding
|
DVL1 |
0.363 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199632 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23151663 |
Like other wnt co-receptors, syndecan 4 directly interacts with dvl during pcp 1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SDC4 | up-regulates
binding
|
DVL3 |
0.249 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199638 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23151663 |
Like other wnt co-receptors, syndecan 4 directly interacts with dvl during pcp 1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SDC4 | up-regulates activity
binding
|
RAC1 |
0.482 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255849 |
|
|
Homo sapiens |
Satellite Cell |
| pmid |
sentence |
| 23290138 |
Rac1 is associated with Sdc4 and is activated by FN binding […] We observed that over-expression of Fzd7, or stimulation with FN resulted in increased levels of active Rac1 in primary myoblasts |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Skeletal Muscle |
| + |
SDC4 | form complex
binding
|
FZD7/SDC4 |
0.54 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255847 |
|
|
Homo sapiens |
Satellite Cell |
| pmid |
sentence |
| 23290138 |
We next examined whether endogenous Fzd7 and Sdc4 form a receptor complex in satellite cells […] Therefore, we conclude that Fzd7 and Sdc4 form a co-receptor complex in activated satellite cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Skeletal Muscle |
| + |
RSPO2 | up-regulates
binding
|
SDC4 |
0.268 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-172719 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21397842 |
We show that rspo3 binds syndecan 4 (sdc4) and that together they activate wnt/pcp signaling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
F2RL1 | up-regulates quantity by expression 
transcriptional regulation
|
SDC4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254844 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 21072196 |
Both PAR2 and PAR1 activation resulted in up-regulated expression of several genes (CD44, FOSL1, TNFRSF12A, RAB3A, COPEB, CORO1C, THBS1, SDC4) known to be important in cancer. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Integrator complex | down-regulates quantity by repression 
transcriptional regulation
|
SDC4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261480 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 25675981 |
The Integrator complex controls the termination of transcription at diverse classes of gene targets.|Following INTS3 or INTS9 knockdown, the levels of SDC4, JUNB, FOSL1, and GADD45B increased, suggesting that the Integrator complex negatively regulates the transcription of these genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FN1 | up-regulates activity
binding
|
SDC4 |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255846 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23290138 |
Sdc4 is a high affinity receptor for fibronectin (FN) […] Therefore, we conclude that Sdc4 binds FN on activated satellite cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
F2R | up-regulates quantity by expression
transcriptional regulation
|
SDC4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254852 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 21072196 |
Both PAR2 and PAR1 activation resulted in up-regulated expression of several genes (CD44, FOSL1, TNFRSF12A, RAB3A, COPEB, CORO1C, THBS1, SDC4) known to be important in cancer. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RSPO3 | up-regulates
binding
|
SDC4 |
0.435 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-172756 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21397842 |
Here, we show that rspo3 binds syndecan 4 (sdc4) and that together they activate wnt/pcp signaling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SDC4 | up-regulates
binding
|
DVL2 |
0.26 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199635 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23151663 |
Like other wnt co receptors, syndecan 4 directly interacts with dvl during pcp. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ADAM12 | up-regulates
binding
|
SDC4 |
0.443 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-96931 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12509413 |
The adam12 cysteine-rich domain (radam12-cys) supports cell attachment using syndecan-4 as a primary cell surface receptor that subsequently triggers beta(1) integrin-dependent cell spreading, stress fiber assembly, and focal adhesion formation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Ovary |
3.0
SDC4
- 
- 