| + |
MAP3K8 | up-regulates 
phosphorylation
|
MAP2K1 |
0.556 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-129690 |
Ser218 |
VSGQLIDsMANSFVG |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 15466476 |
Cot proteins were used in an in vitro kinase assay using mek as a substrate. Samples were analyzed by western blotting. As seen in the cascade activity assay only wild-type cot was active against mekregulation of cot is of great interest to the signaling field since the cot/mek/erk pathway potentially plays a role in the etiology of inflammatory autoimmune diseases. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-36449 |
Ser222 |
LIDSMANsFVGTRSY |
Homo sapiens |
|
| pmid |
sentence |
| 8131746 |
Activation of mek family kinases requires phosphorylation of two conserved ser/thr residues.Phosphopeptide analysis demonstrated that serine residues 218 and 222 of human mek1 are the primary sites for phosphorylation by c-raf |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-36453 |
Ser244 |
GTHYSVQsDIWSMGL |
Homo sapiens |
|
| pmid |
sentence |
| 8131746 |
Activation of mek family kinases requires phosphorylation of two conserved ser/thr residues.Phosphopeptide analysis demonstrated that serine residues 218 and 222 of human mek1 are the primary sites for phosphorylation by c-raf |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-36457 |
Ser248 |
SVQSDIWsMGLSLVE |
Homo sapiens |
|
| pmid |
sentence |
| 8131746 |
Activation of mek family kinases requires phosphorylation of two conserved ser/thr residues.Phosphopeptide analysis demonstrated that serine residues 218 and 222 of human mek1 are the primary sites for phosphorylation by c-raf |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| + |
MAP3K8 | up-regulates
phosphorylation
|
MAP2K2 |
0.415 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-129694 |
Ser222 |
VSGQLIDsMANSFVG |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 15466476 |
Cot proteins were used in an in vitro kinase assay using mek as a substrate. Samples were analyzed by western blotting. As seen in the cascade activity assay only wild-type cot was active against mekregulation of cot is of great interest to the signaling field since the cot/mek/erk pathway potentially plays a role in the etiology of inflammatory autoimmune diseases. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-129698 |
Ser226 |
LIDSMANsFVGTRSY |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 15466476 |
Cot proteins were used in an in vitro kinase assay using mek as a substrate. Samples were analyzed by western blotting. As seen in the cascade activity assay only wild-type cot was active against mekregulation of cot is of great interest to the signaling field since the cot/mek/erk pathway potentially plays a role in the etiology of inflammatory autoimmune diseases. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
AKT1 | up-regulates activity
phosphorylation
|
MAP3K8 |
0.538 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252571 |
Ser400 |
EDQPRCQsLDSALLE |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 12138205 |
Akt-dependent phosphorylation of Cot occurs exclusively on serines 400 and 413. Akt to phosphorylate Cot at two sites in the carboxy-terminal domain, at least one of which may promote binding of substrates or coactivators to Cot, or alternatively may relieve binding of a negative regulator. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252572 |
Ser413 |
LERKRLLsRKELELP |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 12138205 |
Akt-dependent phosphorylation of Cot occurs exclusively on serines 400 and 413. Akt to phosphorylate Cot at two sites in the carboxy-terminal domain, at least one of which may promote binding of substrates or coactivators to Cot, or alternatively may relieve binding of a negative regulator. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
AKT | up-regulates activity
phosphorylation
|
MAP3K8 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251480 |
Ser400 |
EDQPRCQsLDSALLE |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 12138205 |
Akt-dependent phosphorylation of Cot occurs exclusively on serines 400 and 413. Akt to phosphorylate Cot at two sites in the carboxy-terminal domain, at least one of which may promote binding of substrates or coactivators to Cot, or alternatively may relieve binding of a negative regulator. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251481 |
Ser413 |
LERKRLLsRKELELP |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 12138205 |
Akt-dependent phosphorylation of Cot occurs exclusively on serines 400 and 413. Akt to phosphorylate Cot at two sites in the carboxy-terminal domain, at least one of which may promote binding of substrates or coactivators to Cot, or alternatively may relieve binding of a negative regulator. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
MAP3K8 | up-regulates
phosphorylation
|
PLK1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-92274 |
Thr210 |
YDGERKKtLCGTPNY |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 12207013 |
Xplkk1 phosphorylates and activates mammalian plk / xplkk1 phosphorylates thr-210 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAP3K8 | up-regulates activity
phosphorylation
|
MAP3K14 |
0.539 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249387 |
Thr559 |
TGDYIPGtETHMAPE |
Homo sapiens |
|
| pmid |
sentence |
| 9742107 |
In studies of NIK, we found that Thr-559 located within the activation loop of its kinase domain regulates NIK action. Alanine substitution of Thr-559 but not other serine or threonine residues within the activation loop abolishes its activity and its ability to phosphorylate and activate IKKalpha |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NfKb-p65/p50 | down-regulates 
binding
|
MAP3K8 |
0.553 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-216289 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22435554 |
Tpl-2 is stoichiometrically complexed with the nf-kb inhibitory protein, nf-kb1 p105, and the ubiquitin-binding protein abin-2, both of which are required to maintain tpl-2 protein stability. Binding to p105 also prevents tpl-2 from phosphorylating mek |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Toll like receptors |
| + |
NFKB1 | down-regulates
binding
|
MAP3K8 |
0.675 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-196747 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22435554 |
Tpl-2 is stoichiometrically complexed with the nf-kb inhibitory protein, nf-kb1 p105, and the ubiquitin-binding protein abin-2, both of which are required to maintain tpl-2 protein stability. Binding to p105 also prevents tpl-2 from phosphorylating mek |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAP3K8 | up-regulates
phosphorylation
|
MEK1/2 |
0.556 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-244892 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8131746 |
Activation of mek family kinases requires phosphorylation of two conserved ser/thr residues.Phosphopeptide analysis demonstrated that serine residues 218 and 222 of human mek1 are the primary sites for phosphorylation by c-raf |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-244904 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 15466476 |
Cot proteins were used in an in vitro kinase assay using mek as a substrate. Samples were analyzed by western blotting. As seen in the cascade activity assay only wild-type cot was active against mekregulation of cot is of great interest to the signaling field since the cot/mek/erk pathway potentially plays a role in the etiology of inflammatory autoimmune diseases. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Toll like receptors |
| + |
MAP3K8 | up-regulates
phosphorylation
|
MAP2K4 |
0.539 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-196744 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22435554 |
Furthermore, we found that immunoprecipitated tpl-2 could directly phosphorylate and activate both mek-1 and mkk4 (also known as sek-1) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TLR4 | up-regulates activity 
|
MAP3K8 |
0.399 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256083 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 16484370 |
Our findings indicate that the Tpl2/MEK/ERK signaling module is a master regulator of ERK-dependent gene expression downstream of TLRs in different hemopoietic cells |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
MAP3K8 | up-regulates activity
|
ERK1/2 |
0.363 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256078 |
|
|
Mus musculus |
B-lymphocyte, Macrophage |
| pmid |
sentence |
| 16484370 |
Mitogen-activated protein 3 kinase Tpl2, levels of which are markedly reduced in nfkb1(-/-) cells, is required for extracellular signal-regulated kinase (ERK) activation in bone marrow-derived macrophages and B cells stimulated with diverse TLR ligands |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Toll like receptors |
| + |
TRAF6 | up-regulates activity
|
MAP3K8 |
0.428 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252254 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 16371247 |
The activation of Cot-MKK1-ERK1/ERK2 signalling pathway by IL-1 is dependent on the activity of the transducer protein TRAF6. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Toll like receptors |
3.0
MAP3K8
- 
- 