Summary

Name MAP3K8
Full Name Mitogen-activated protein kinase kinase kinase 8
Synonyms Cancer Osaka thyroid oncogene, Proto-oncogene c-Cot, Serine/threonine-protein kinase cot, Tumor progression locus 2, TPL-2 | COT, ESTF
Primary ID P41279
Links - -
Type protein
Relations 20
Pathways Monocyte: IL10 transcriptional regulation, Toll like receptors
Function Required for lipopolysaccharide (LPS)-induced, TLR4-mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the proinflammatory cytokine TNF-alpha (TNF) during immune responses. Involved in the regulation of T-helper cell differentiation and IFNG expression in T-cells. Involved in mediating host resistance to bacterial infection through negative regulation of type I interferon (IFN) production. In vitro, activates MAPK/ERK pathway in response to IL1 in an IRAK1-independent manner, leading to up-regulation of IL8 and CCL4. Transduces CD40 and TNFRSF1A signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. May also play a role in the transduction of TNF signals that activate JNK and NF-kappa-B in some cell types. In adipocytes, activates MAPK/ERK pathway in an IKBKB-dependent manner in response to IL1B and TNF, but not insulin, leading to induction of lipolysis. Plays a role in the cell cycle. Isoform 1 shows some transforming activity, although it is much weaker than that of the activated oncogenic variant.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation MAP2K1 0.551
Publications: 4 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MAP2K2 0.412
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MAP3K8 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MAP3K8 0.534
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PLK1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MAP3K14 0.534
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MAP2K4 0.535
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png MAP3K8 0.43
Publications: 1 Organism: Homo Sapiens
Pathways:Toll like receptors
+ up-regulates img/direct-activation.png phosphorylation MEK1/2 0.551
Publications: 2 Organism: Homo Sapiens
Pathways:Toll like receptors
+ up-regulates activity img/indirect-activation.png MAP3K8 0.403
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png binding MAP3K8 0.553
Publications: 1 Organism: Homo Sapiens
Pathways:Toll like receptors
+ up-regulates activity img/indirect-activation.png ERK1/2 0.364
Publications: 1 Organism: Mus Musculus
Pathways:Toll like receptors
+ down-regulates img/direct_inhibition.png binding MAP3K8 0.672
Publications: 1 Organism: Homo Sapiens