3.0
Summary
| Name |  SCNN1BView Modifications |
| Full Name | Amiloride-sensitive sodium channel subunit beta |
| Synonyms | Beta-NaCH, Epithelial Na(+) channel subunit beta, Beta-ENaC, ENaCB, Nonvoltage-gated sodium channel 1 subunit beta, SCNEB |
| Primary ID | P51168 |
| Links |  -  -  |
| Type | protein |
| Relations | 6 |
| Function | Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | MAPK3 | down-regulates quantity by destabilization 
phosphorylation
|
SCNN1B | 0.282 |
| Publications: | 1 | Organism: | In Vitro | |
| + | MAPK1 | down-regulates quantity by destabilization
phosphorylation
|
SCNN1B | 0.294 |
| Publications: | 1 | Organism: | In Vitro | |
| + | SCNN1B | up-regulates activity 
binding
|
CACNA1H | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Tissue: | Brain | |||
| + | Gbeta | down-regulates quantity by destabilization
phosphorylation
|
SCNN1B | 0.2 |
| Publications: | 1 | Organism: | In Vitro | |
| + | ERK1/2 | down-regulates quantity by destabilization
phosphorylation
|
SCNN1B | 0.2 |
| Publications: | 1 | Organism: | In Vitro | |
| + | SCNN1B | up-regulates quantity
relocalization
|
sodium(1+) | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |