| + |
SRC | up-regulates 
phosphorylation
|
STAT5B |
0.577 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-99002 |
Tyr679 |
DRPKDEVySKYYTPV |
Homo sapiens |
|
| pmid |
sentence |
| 12621061 |
Stat5 is activated by a broad spectrum of cytokines, as well as non-receptor tyrosine kinases, such as src. these conformational differences may in part be due to differential effects of prl and src on stat5b tyrosine phosphorylation, since src induced several additional sites of tyrosine phosphorylation of stat5b at residues other than tyr-699, including tyr-724 and tyr-679. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTPN1 | down-regulates activity 
dephosphorylation
|
STAT5B |
0.679 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248429 |
Tyr699 |
TAKAVDGyVKPQIKQ |
Chlorocebus aethiops |
COS Cell |
| pmid |
sentence |
| 10993888 |
A Cytosolic Protein-tyrosine Phosphatase PTP1B Specifically Dephosphorylates and Deactivates Prolactin-activated STAT5a and STAT5b |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
EGFR | up-regulates activity
phosphorylation
|
STAT5B |
0.83 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251098 |
Tyr699 |
TAKAVDGyVKPQIKQ |
Homo sapiens |
HEK-293 Cell, Breast Cancer Cell Line |
| pmid |
sentence |
| 11751923 |
We have shown that EGF activates STAT5b not only in a HEK293 cell model in which the EGFR is stably overexpressed but also in the MDA-MB468 breast cancer cell line. Furthermore, EGF (but not GH) is able to activate tyrosine phosphorylation of a Tyr-699 mutant of STAT5b. | Fig. 2 A (bottom panels) demonstrates that EGF-induced phosphorylation of tyrosine 699 (the well-described site of STAT5b phosphorylation) is detected only in the EGFR-overexpressing MDA-MB468 cells and not the MCF-7 cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTPN1 | down-regulates
dephosphorylation
|
STAT5B |
0.679 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-82042 |
Tyr699 |
TAKAVDGyVKPQIKQ |
Homo sapiens |
|
| pmid |
sentence |
| 10993888 |
A cytosolic protein-tyrosine phosphatase ptp1b specifically dephosphorylates and deactivates prolactin-activated stat5a and stat5b. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Breast |
| + |
PTK6 | up-regulates
phosphorylation
|
STAT5B |
0.43 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-159066 |
Tyr699 |
TAKAVDGyVKPQIKQ |
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 17997837 |
Phosphospecific antibodies, mutational analysis, and in vitro kinase assays demonstrated that brk specifically mediated stat5b phosphorylation at the activating tyrosine, y699. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EGFR | up-regulates
phosphorylation
|
STAT5B |
0.83 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-113393 |
Tyr725 |
AGGGSATyMDQAPSP |
Homo sapiens |
|
| pmid |
sentence |
| 11751923 |
Novel activation of stat5b in response to epidermal growth factor. novel activation of stat5b in response to epidermal growth factor. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-113397 |
Tyr740 |
AVCPQAHyNMYPQNP |
Homo sapiens |
|
| pmid |
sentence |
| 11751923 |
Novel activation of stat5b in response to epidermal growth factor. novel activation of stat5b in response to epidermal growth factor. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-113401 |
Tyr743 |
PQAHYNMyPQNPDSV |
Homo sapiens |
HEK-293 Cell, Breast Cancer Cell |
| pmid |
sentence |
| 11751923 |
Novel activation of stat5b in response to epidermal growth factor. novel activation of stat5b in response to epidermal growth factor. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
LCK | up-regulates activity
phosphorylation
|
STAT5B |
0.649 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279056 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16446405 |
A constitutively active Lck kinase promotes cell proliferation and resistance to apoptosis through signal transducer and activator of transcription 5b activation.|Expression of the active Lck kinase induces both tyrosine phosphorylation and DNA binding activity of signal transducer and activator of transcription 5b (STAT5b), a STAT family member activated in a variety of tumor cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NCOA1 | up-regulates
binding
|
STAT5B |
0.322 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-100261 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12954634 |
Ncoa-1/src-1 is an essential coactivator of stat5 that binds to the fdl motif in the alpha-helical region of the stat5 transactivation domain. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Breast |
| + |
JAK2 | up-regulates
phosphorylation
|
STAT5B |
0.868 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-56894 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9575217 |
Jak2 kinase induces tyrosine phosphorylation, dimerization, nuclear translocation, and dna binding of a concomitantly expressed stat5 protein |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTPN2 | down-regulates activity
dephosphorylation
|
STAT5B |
0.736 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277126 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12359225 |
In the previous study, we demonstrated that the nuclear isoform of T-cell protein-tyrosine phosphatase (TC-PTP) dephosphorylated and deactivated signal transducer and activator of transcription 5a (STAT5a) and STAT5b, thereby negatively regulating prolactin (PRL)-mediated signaling pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EPHA4 | up-regulates activity
phosphorylation
|
STAT5B |
0.375 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278934 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28686668 |
We have shown here that EphA4 can phosphorylate STAT5B, but it is not yet clear whether the nuclear translocation of phosphorylated STAT5B is enhanced by EphA4. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
STAT5B
- 
- 