Summary

Name PTPN2
Full Name Tyrosine-protein phosphatase non-receptor type 2
Synonyms T-cell protein-tyrosine phosphatase, TCPTP | PTPT
Primary ID P17706
Links - -
Type protein
Relations 47
Function Non-receptor type tyrosine-specific phosphatase that dephosphorylates receptor protein tyrosine kinases including INSR, EGFR, CSF1R, PDGFR. Also dephosphorylates non-receptor protein tyrosine kinases like JAK1, JAK2, JAK3, Src family kinases, STAT1, STAT3 and STAT6 either in the nucleus or the cytoplasm. Negatively regulates numerous signaling pathways and biological processes like hematopoiesis, inflammatory response, cell proliferation and differentiation, and glucose homeostasis. Plays a multifaceted and important role in the development of the immune system. Functions in T-cell receptor signaling through dephosphorylation of FYN and LCK to control T-cells differentiation and activation. Dephosphorylates CSF1R, negatively regulating its downstream signaling and macrophage differentiation. Negatively regulates cytokine (IL2/interleukin-2 and interferon)-mediated signaling through dephosphorylation of the cytoplasmic kinases JAK1, JAK3 and their substrate STAT1, that propagate signaling downstream of the cytokine receptors. Also regulates the IL6/interleukin-6 and IL4/interleukin-4 cytokine signaling through dephosphorylation of STAT3 and STAT6 respectively. In addition to the immune system, it is involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth. Activated by the integrin ITGA1/ITGB1, it dephosphorylates EGFR and negatively regulates EGF signaling. Dephosphorylates PDGFRB and negatively regulates platelet-derived growth factor receptor-beta signaling pathway and therefore cell proliferation. Negatively regulates tumor necrosis factor-mediated signaling downstream via MAPK through SRC dephosphorylation. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of the hepatocyte growth factor receptor MET. Plays also an important role in glucose homeostasis. For instance, negatively regulates the insulin receptor signaling pathway through the dephosphorylation of INSR and control gluconeogenesis and liver glucose production through negative regulation of the IL6 signaling pathways. May also bind DNA.

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Modifications Tables

Relations

Regulator Mechanism target score
+ img/unknown.png phosphorylation PTPN2 0.356
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation PTPN2 0.365
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation PDGFRB 0.54
Publications: 2 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png dephosphorylation JAK1 0.758
Publications: 3 Organism: Mus Musculus, Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation KDR 0.546
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation INSR 0.597
Publications: 5 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation INSR 0.597
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation KDR 0.546
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation MET 0.474
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation MET 0.474
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png dephosphorylation GJA1 0.334
Publications: 2 Organism: Homo Sapiens
Tissue: Kidney
+ down-regulates img/direct_inhibition.png dephosphorylation WASL 0.293
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation GHR 0.298
Publications: 4 Organism: Cricetulus Griseus
+ down-regulates activity img/direct_inhibition.png dephosphorylation SHC1 0.548
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation FYN 0.332
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation STAT1 0.723
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation STAT1 0.723
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation STAT3 0.725
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation STAT3 0.725
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png dephosphorylation KDR 0.546
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png AKT1 0.367
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation FKBP4 0.41
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation EGFR 0.616
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation STAT5A 0.722
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation STAT6 0.664
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation SRC 0.708
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation JAK3 0.681
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png AKT 0.367
Publications: 1 Organism: Homo Sapiens