Summary

Name NCOA1
Full Name Nuclear receptor coactivator 1
Synonyms NCoA-1, Class E basic helix-loop-helix protein 74, bHLHe74, Protein Hin-2, RIP160, Renal carcinoma antigen NY-REN-52, Steroid receptor coactivator 1, SRC-1 | BHLHE74, SRC1
Primary ID Q15788
Links - -
Type protein
Relations 23
Pathways Acute Myeloid Leukemia, ASXL1 in AML, Glucocorticoid receptor Signaling
Function Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation NCOA1 0.273
Publications: 2 Organism: Homo Sapiens
Pathways:Glucocorticoid receptor Signaling
+ up-regulates img/direct-activation.png phosphorylation NCOA1 0.372
Publications: 3 Organism: Homo Sapiens
Pathways:Glucocorticoid receptor Signaling
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation APOC3 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ALDOB 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation OTC 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding STAT5B 0.33
Publications: 1 Organism: Homo Sapiens
Tissue: Breast
+ up-regulates img/indirect-activation.png PGR 0.672
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation NCOA1 0.76
Publications: 1 Organism: Homo Sapiens
Pathways:Glucocorticoid receptor Signaling
+ up-regulates img/direct-activation.png phosphorylation NCOA1 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ up-regulates img/direct-activation.png binding ESR1 0.836
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding STAT5A 0.415
Publications: 1 Organism: Homo Sapiens
Tissue: Breast
Pathways:Acute Myeloid Leukemia, Glucocorticoid receptor Signaling
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation RARA 0.691
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, ASXL1 in AML
+ up-regulates img/direct-activation.png phosphorylation NCOA1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PCK2 0.287
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation Aldolase 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding NCOA1 0.289
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, ASXL1 in AML
+ up-regulates activity img/direct-activation.png binding ASXL1 0.289
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, ASXL1 in AML
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation APOA5 0.376
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding NCOA1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CYP7A1 0.448
Publications: 1 Organism: Homo Sapiens