3.0
Summary
| Name |  HK2View Modifications |
| Full Name | Hexokinase-2 |
| Synonyms | Hexokinase type II, HK II, Muscle form hexokinase | |
| Primary ID | P52789 |
| Links |  -  -  |
| Type | protein |
| Relations | 15 |
| Function | Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively) (PubMed:23185017, PubMed:26985301, PubMed:29298880). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (PubMed:29298880). Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis (PubMed:18350175). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | AKT | up-regulates activity 
phosphorylation
|
HK2 | 0.2 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| Pathways: | Glycolysis and Gluconeogenesis | |||
| + | AKT1 | up-regulates activity
phosphorylation
|
HK2 | 0.464 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | HK2 | up-regulates activity 
|
Glycolysis | 0.7 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | FLT3 | up-regulates activity
|
HK2 | 0.263 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | HIF-1 complex | up-regulates quantity by expression
transcriptional regulation
|
HK2 | 0.315 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Glycolysis and Gluconeogenesis | |||
| + | TP53 | down-regulates quantity by repression 
transcriptional regulation
|
HK2 | 0.429 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Glycolysis and Gluconeogenesis | |||
| + | HK2 | down-regulates quantity
chemical modification
|
α-D-glucose | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Glycolysis and Gluconeogenesis | |||
| + | BACH1 | up-regulates quantity
transcriptional regulation
|
HK2 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | glucose | up-regulates quantity by stabilization
|
HK2 | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | HK2 | down-regulates activity 
|
Cell_death | 0.7 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | MYC | up-regulates quantity
transcriptional regulation
|
HK2 | 0.384 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | Chaperone-mediated autophagy | down-regulates quantity by destabilization
|
HK2 | 0.7 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | HK2 | up-regulates quantity
chemical modification
|
alpha-D-glucose 6-phosphate(2-) | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Glycolysis and Gluconeogenesis | |||
| + | TRAF6 | down-regulates quantity
ubiquitination
|
HK2 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |