| + |
FOXP2 | up-regulates quantity by expression 
transcriptional regulation
|
RELN |
0.374 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266833 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25232744 |
By interacting with CASK, TBR1 regulates several ASD candidate genes, such as GRIN2B, AUTS2 and RELN—all of which are recurrently mutated in ASD. In areas of the brain with overlapping expression patterns, such as in glutamatergic layer 6 neurons, the TBR1–FOXP2 interaction may result in co-ordinated regulation of common downstream targets. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Brain |
| + |
MECP2 | down-regulates quantity by repression 
transcriptional regulation
|
RELN |
0.389 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254578 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19029285 |
induction of the reelin and GAD67 mRNAs is accompanied by the dissociation of repressor complexes containing all three DNMTs, MeCP2, and HDAC1 from the corresponding promoters and by increased local histone acetylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Rett syndrome |
| + |
TOP2B | up-regulates quantity by expression 
transcriptional regulation
|
RELN |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242207 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24463367 |
While Top2a is essential in proliferating cells and has been linked to DNA replication and chromosome condensation/segregation, Top2b has been clearly indicated in regulating gene expression (e.g. Reln, Dab1, Catna2, Cdh13, Sst, Pbx3, and Epha7) during brain development |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DNMT1 | down-regulates quantity by repression
transcriptional regulation
|
RELN |
0.445 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254575 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19029285 |
induction of the reelin and GAD67 mRNAs is accompanied by the dissociation of repressor complexes containing all three DNMTs, MeCP2, and HDAC1 from the corresponding promoters and by increased local histone acetylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Rett syndrome |
| + |
RELN | up-regulates
binding
|
VLDLR |
0.784 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-106295 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11278667 |
The hypothesis that the vldl receptor signals in response to reelin binding was recently supported by studies (37) showing direct binding of reelin to the vldl receptor and changes in tyrosine phosphorylation in response to reelin-vldl receptor association. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KLF2 | up-regulates quantity by expression
transcriptional regulation
|
RELN |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266048 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21530336 |
KLF2 transactivates the reelin promoter in K562 cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RELN | up-regulates
|
Synaptic_plasticity |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265772 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 17584923 |
Reln, encoding an extracellular signaling molecule essential for neuronal lamination and synaptic plasticity |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Rett syndrome |
| + |
HDAC1 | down-regulates quantity by repression
transcriptional regulation
|
RELN |
0.282 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254577 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19029285 |
induction of the reelin and GAD67 mRNAs is accompanied by the dissociation of repressor complexes containing all three DNMTs, MeCP2, and HDAC1 from the corresponding promoters and by increased local histone acetylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
RELN
- 
- 