Summary

Name FOXO4
Full Name Forkhead box protein O4
Synonyms Fork head domain transcription factor AFX1 | AFX, AFX1, MLLT7
Primary ID P98177
Links - -
Type protein
Relations 38
Function Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle. Involved in increased proteasome activity in embryonic stem cells (ESCs) by activating expression of PSMD11 in ESCs, leading to enhanced assembly of the 26S proteasome, followed by higher proteasome activity.

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation FOXO4 0.755
Publications: 5 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation FOXO4 0.755
Publications: 2 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png phosphorylation FOXO4 0.2
Publications: 4 Organism: Homo Sapiens
Pathways:Insulin Signaling
+ down-regulates activity img/direct_inhibition.png phosphorylation FOXO4 0.2
Publications: 2 Organism: Mus Musculus
Pathways:Insulin Signaling
+ up-regulates img/direct-activation.png phosphorylation FOXO4 0.2
Publications: 4 Organism: Homo Sapiens
Tissue: Skin
+ down-regulates activity img/direct_inhibition.png phosphorylation FOXO4 0.59
Publications: 3 Organism: Homo Sapiens, Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation FOXO4 0.596
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation FOXO4 0.2
Publications: 2 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png phosphorylation FOXO4 0.499
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation TRIM63 0.35
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation FBXO32 0.387
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation IDH1 0.269
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation FOXO4 0.332
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation FOXO4 0.351
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation FOXO4 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation FOXO4 0.324
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation FOXO4 0.403
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation FOXO4 0.2
Publications: 1 Organism: Bos Taurus
+ down-regulates activity img/direct_inhibition.png binding FOXO4 0.315
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png deacetylation FOXO4 0.734
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png relocalization FOXO4 0.256
Publications: 1 Organism: Homo Sapiens