Insulin Signaling

Pathway ID: SIGNOR-INSRView in NDEx

Description: In physiological conditions, insulin controls critical energy functions such as glucose and lipid metabolism. Insulin binds and activates the insulin receptor tyrosine kinase (IR), which phosphorylates and recruits different substrate adaptors. Tyrosine phosphorylated substrates, in turn, act as scaffolds for numerous partners, initiating a signaling cascade that involve via PI3K/Akt and Ras/MAP kinase pathways.

33 Seed Entities

Organism:
Name Primary ID
PIK3CB P42338
SREBF1 P36956
TSC1 Q92574
TSC SIGNOR-C101
GRB2 P62993
Lipogenesis SIGNOR-PH30
mTORC1 SIGNOR-C3
INSR P06213
RPS6KB1 P23443
RAF1 P04049
RHEB Q15382
Proliferation SIGNOR-PH4
EIF4EBP1 Q13541
ERK1/2 SIGNOR-PF1
INS P01308
PDX1 P52945
SOS1 Q07889
AKT SIGNOR-PF24
PTEN P60484
PTPN1 P18031
MEK1/2 SIGNOR-PF25
JUN P05412
SGK1 O00141
Glycogen_synthesis SIGNOR-PH39
PDPK1 O15530
GYS1 P13807
EIF4E P06730
PIP3 CHEBI:16618
Protein_synthesis SIGNOR-PH29
IRS1 P35568
FOXO3 O43524
HRAS P01112
GSK3B P49841