3.0
Summary
| Name |  LIPEView Modifications |
| Full Name | Hormone-sensitive lipase |
| Synonyms | HSL |
| Primary ID | Q05469 |
| Links |  -  -  |
| Type | protein |
| Relations | 13 |
| Function | Lipase with broad substrate specificity, catalyzing the hydrolysis of triacylglycerols (TAGs), diacylglycerols (DAGs), monoacylglycerols (MAGs), cholesteryl esters and retinyl esters (PubMed:8812477, PubMed:15955102, PubMed:15716583, PubMed:19800417). Shows a preferential hydrolysis of DAGs over TAGs and MAGs and preferentially hydrolyzes the fatty acid (FA) esters at the sn-3 position of the glycerol backbone in DAGs (PubMed:19800417). Preferentially hydrolyzes FA esters at the sn-1 and sn-2 positions of the glycerol backbone in TAGs (By similarity). Catalyzes the hydrolysis of 2-arachidonoylglycerol, an endocannabinoid and of 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor (By similarity). In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production (By similarity). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PRKACA | up-regulates activity 
phosphorylation
|
LIPE | 0.585 |
| Publications: | 3 | Organism: | Mus Musculus | |
| + | AMPK | down-regulates 
phosphorylation
|
LIPE | 0.377 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PRKAA1 | down-regulates
phosphorylation
|
LIPE | 0.388 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CAMK2A | down-regulates
phosphorylation
|
LIPE | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PRKACA | down-regulates
phosphorylation
|
LIPE | 0.585 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PKA | up-regulates activity
phosphorylation
|
LIPE | 0.2 |
| Publications: | 2 | |||
| + | MAPK3 | up-regulates activity
phosphorylation
|
LIPE | 0.425 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | MAPK1 | up-regulates activity
phosphorylation
|
LIPE | 0.375 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | Gbeta | up-regulates activity
phosphorylation
|
LIPE | 0.2 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | ERK1/2 | up-regulates activity
phosphorylation
|
LIPE | 0.2 |
| Publications: | 1 | Organism: | Mus Musculus | |