Summary

Name RBPJ
Full Name Recombining binding protein suppressor of hairless
Synonyms CBF-1, J kappa-recombination signal-binding protein, RBP-J kappa, RBP-J, RBP-JK, Renal carcinoma antigen NY-REN-30 | IGKJRB, IGKJRB1, RBPJK, RBPSUH
Primary ID Q06330
Links - -
Type protein
Relations 23
Function Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA. Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen) (PubMed:23303788).

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Relations

Regulator Mechanism target score
+ up-regulates quantity img/direct-activation.png transcriptional regulation HES1 0.68
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/direct-activation.png binding HES1
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CDKN1A 0.06
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation NFKB2 0.31
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding RBPJ 0.51
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding MAML2 0.57
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding RBPJ/NOTCH
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding RBPJ 0.68
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding RBPJ 0.33
Publications: 1 Organism: Homo Sapiens
Tissue: Kidney
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation CDKN1A 0.06
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png binding RBPJ
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding RBPJ 0.79
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding RBPJ 0.10
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding MAML3 0.68
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PAX7 0.26
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ up-regulates img/direct-activation.png binding DUSP1 0.24
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png binding RBPJ 0.57
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding RBPJ 0.39
Publications: 1 Organism: Cricetulus Griseus
+ down-regulates img/direct_inhibition.png binding RBPJ 0.70
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle, Lung
+ up-regulates img/direct-activation.png binding RBPJ 0.91
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding GTF2A2 0.25
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding CIR1 0.73
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding RBPJ 0.43
Publications: 1 Organism: Homo Sapiens