Summary

Name RBPJ
Full Name Recombining binding protein suppressor of hairless
Synonyms CBF-1, J kappa-recombination signal-binding protein, RBP-J kappa, RBP-J, RBP-JK, Renal carcinoma antigen NY-REN-30 | IGKJRB, IGKJRB1, RBPJK, RBPSUH
Primary ID Q06330
Links - -
Type protein
Relations 26
Pathways Satellite: NOTCH
Function Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA (PubMed:21991380). Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen) (PubMed:23303788). Negatively regulates the phagocyte oxidative burst in response to bacterial infection by repressing transcription of NADPH oxidase subunits (By similarity).

Viewer

Relations

Regulator Mechanism target score
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation NOTCH 0.949
Publications: 1
+ up-regulates img/direct-activation.png binding RBPJ 0.868
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding RBPJ/NOTCH 0.949
Publications: 3 Organism: Homo Sapiens,
+ down-regulates img/direct_inhibition.png binding RBPJ 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding RBPJ 0.645
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png transcriptional regulation HES1 0.583
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png binding RBPJ 0.673
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding RBPJ 0.851
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation CDKN1A 0.316
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CDKN1A 0.316
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation NFKB2 0.272
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding RBPJ 0.273
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates img/direct-activation.png binding PAX7 0.374
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding MAML2 0.863
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png binding HES1 0.583
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding DUSP1 0.253
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png binding RBPJ 0.69
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding RBPJ 0.583
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding RBPJ 0.949
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding MAML3 0.87
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding GTF2A2 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding CIR1 0.659
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding RBPJ 0.431
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding RBPJ 0.282
Publications: 1 Organism: Homo Sapiens