Relation Results

Summary

Name FOXM1
Full Name Forkhead box protein M1
Synonyms Forkhead-related protein FKHL16, Hepatocyte nuclear factor 3 forkhead homolog 11, HFH-11, HNF-3/fork-head homolog 11, M-phase phosphoprotein 2, MPM-2 reactive phosphoprotein 2, Transcription factor Trident, Winged-helix factor from INS-1 cells | FKHL16, HFH11, MPP2, WIN
Primary ID Q08050
Links - -
Type protein
Relations 20
Function Transcriptional factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell pr ...
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Type: Score: Layout: SPV 
0.7560.7570.7140.6150.3590.6980.7440.20.510.5280.3550.3080.274CDK1FOXM1CyclinB/CDK1CHEK2CDK4GSK3BPLK1CDK2SLC27A2MELKCTNNB1USP5SCF-FBW7TEAD1

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ CDK1up-regulates img/direct-activation.png phosphorylation FOXM1 0.756
Identifier Residue Sequence Organism Cell Line
SIGNOR-187876 Ser251 MIQFAINsTERKRMT Homo sapiens
pmid sentence
A conserved phosphorylation site within the forkhead domain of foxm1b is required for its activation by cyclin-cdk1the phosphorylation at ser-251 is critical for the activation of foxm1.
Identifier Residue Sequence Organism Cell Line
SIGNOR-187880 Thr611 ETLPISStPSKSVLP Homo sapiens
pmid sentence
A conserved phosphorylation site within the forkhead domain of foxm1b is required for its activation by cyclin-cdk1further analysis reveals that the leu-641 residue within an lxl motif is required for the recruitment of the cyclin-cdk complex, and the thr-596 residue is a critical cdk1 phosphorylation site within the activation domain of foxm1b. Cdk-dependent phosphorylation stimulates the foxm1b transcriptional activity
Publications: 2 Organism: Homo Sapiens
+ CyclinB/CDK1up-regulates img/direct-activation.png phosphorylation FOXM1 0.757
Identifier Residue Sequence Organism Cell Line
SIGNOR-216833 Ser251 MIQFAINsTERKRMT Homo sapiens
pmid sentence
A conserved phosphorylation site within the forkhead domain of foxm1b is required for its activation by cyclin-cdk1the phosphorylation at ser-251 is critical for the activation of foxm1.
Identifier Residue Sequence Organism Cell Line
SIGNOR-216837 Thr611 ETLPISStPSKSVLP Homo sapiens
pmid sentence
A conserved phosphorylation site within the forkhead domain of foxm1b is required for its activation by cyclin-cdk1further analysis reveals that the leu-641 residue within an lxl motif is required for the recruitment of the cyclin-cdk complex, and the thr-596 residue is a critical cdk1 phosphorylation site within the activation domain of foxm1b. Cdk-dependent phosphorylation stimulates the foxm1b transcriptional activity
Publications: 2 Organism: Homo Sapiens
+ CHEK2up-regulates img/direct-activation.png phosphorylation FOXM1 0.714
Identifier Residue Sequence Organism Cell Line
SIGNOR-150746 Ser376 PLLPRVSsYLVPIQF Homo sapiens U2-OS Cell
pmid sentence
Chk2 mediates stabilization of the foxm1 transcription factor to stimulate expression of dna repair genesthis phosphorylation of foxm1 on serine residue 361 caused increased stability of the foxm1 protein
Publications: 1 Organism: Homo Sapiens
+ CDK4up-regulates img/direct-activation.png phosphorylation FOXM1 0.615
Identifier Residue Sequence Organism Cell Line
SIGNOR-177251 Ser4 sPRRPLIL Homo sapiens
pmid sentence
We identified the forkhead box m1 (foxm1) transcription factor as a common critical phosphorylation target. Cdk4/6 stabilize and activate foxm1these data identify five overlapping in vivo and in vitro cdk4/6 target sites in foxm1 (s4, s35, t611, t620 and t627)
Identifier Residue Sequence Organism Cell Line
SIGNOR-177255 Thr611 ETLPISStPSKSVLP Homo sapiens
pmid sentence
We identified the forkhead box m1 (foxm1) transcription factor as a common critical phosphorylation target. Cdk4/6 stabilize and activate foxm1these data identify five overlapping in vivo and in vitro cdk4/6 target sites in foxm1 (s4, s35, t611, t620 and t627)
Identifier Residue Sequence Organism Cell Line
SIGNOR-177259 Thr620 SKSVLPRtPESWRLT Homo sapiens
pmid sentence
We identified the forkhead box m1 (foxm1) transcription factor as a common critical phosphorylation target. Cdk4/6 stabilize and activate foxm1these data identify five overlapping in vivo and in vitro cdk4/6 target sites in foxm1 (s4, s35, t611, t620 and t627)
Identifier Residue Sequence Organism Cell Line
SIGNOR-177263 Thr627 TPESWRLtPPAKVGG Homo sapiens
pmid sentence
We identified the forkhead box m1 (foxm1) transcription factor as a common critical phosphorylation target. Cdk4/6 stabilize and activate foxm1these data identify five overlapping in vivo and in vitro cdk4/6 target sites in foxm1 (s4, s35, t611, t620 and t627)
Identifier Residue Sequence Organism Cell Line
SIGNOR-177266 Homo sapiens
pmid sentence
We identified the forkhead box m1 (foxm1) transcription factor as a common critical phosphorylation target. Cdk4/6 stabilize and activate foxm1, thereby maintain expression of g1/s phase genes, suppress the levels of reactive oxygen species (ros), and protect cancer cells from senescence.
Publications: 5 Organism: Homo Sapiens
+ GSK3Bdown-regulates quantity by destabilization img/direct_inhibition.png phosphorylation FOXM1 0.359
Identifier Residue Sequence Organism Cell Line
SIGNOR-277208 Ser474 S-->A Homo sapiens HEK-293T Cell
pmid sentence
GSK3 phosphorylates FoxM1 on serine 474 which induces FoxM1 ubiquitination mediated by FBXW7.
Publications: 1 Organism: Homo Sapiens
+ PLK1up-regulates img/direct-activation.png phosphorylation FOXM1 0.698
Identifier Residue Sequence Organism Cell Line
SIGNOR-187888 Ser730 VLDTMNDsLSKILLD Homo sapiens
pmid sentence
It has been reported that plk1 could directly phosphorylate foxm1 at ser-715 and ser-724 for full activation and proper mitotic progression
Identifier Residue Sequence Organism Cell Line
SIGNOR-187892 Ser739 SKILLDIsFPGLDED Homo sapiens
pmid sentence
It has been reported that plk1 could directly phosphorylate foxm1 at ser-715 and ser-724 for full activation and proper mitotic progression
Publications: 2 Organism: Homo Sapiens
+ CDK2up-regulates activity img/direct-activation.png phosphorylation FOXM1 0.744
Identifier Residue Sequence Organism Cell Line
SIGNOR-250731 Thr611 ETLPISStPSKSVLP U2-OS Cell
pmid sentence
We demonstrated that FoxM1B transcriptional activity requires binding of either S-phase or M-phase Cdk-cyclin complexes to mediate efficient Cdk phosphorylation of the FoxM1B Thr 596 residue, which is essential for recruitment of p300/CBP coactivator proteins.
Publications: 1
+ FOXM1up-regulates quantity by expression img/indirect-activation.png SLC27A2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-260414 Homo sapiens
pmid sentence
FOXM1 as a prognostic biomarker promotes endometrial cancer progression via transactivation of SLC27A2 expression.
Publications: 1 Organism: Homo Sapiens
+ MELKup-regulates activity img/direct-activation.png phosphorylation FOXM1 0.51
Identifier Residue Sequence Organism Cell Line
SIGNOR-278412 Homo sapiens
pmid sentence
MELK Activates FOXM1 Transcriptional Activity Leading to Upregulation of Mitotic Gene Expression.|The autoradiogram clearly shows in vitro phosphorylation of FOXM1 by MELK and CDK2 and cyclinA.
Publications: 1 Organism: Homo Sapiens
+ FOXM1up-regulates activity img/direct-activation.png binding CTNNB1 0.528
Identifier Residue Sequence Organism Cell Line
SIGNOR-277211 Homo sapiens HEK-293T Cell
pmid sentence
Nuclear FoxM1 then directly interacted with nuclear β‐catenin, which released β‐catenin from ICAT and enhanced recruitment of β‐catenin to the promoter of Wnt target gene, hence increasing the expression of Wnt target gene.
Publications: 1 Organism: Homo Sapiens
+ USP5up-regulates quantity by stabilization img/direct-activation.png deubiquitination FOXM1 0.355
Identifier Residue Sequence Organism Cell Line
SIGNOR-277210 Homo sapiens HEK-293T Cell
pmid sentence
 Wnt signaling activation inhibits FoxM1 phosphorylation by GSK3-Axin complex and leads to interaction between FoxM1 and deubiquitinating enzyme USP5, thereby deubiquitination and stabilization of FoxM1.
Publications: 1 Organism: Homo Sapiens
+ SCF-FBW7down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination FOXM1 0.308
Identifier Residue Sequence Organism Cell Line
SIGNOR-277209 Homo sapiens HEK-293T Cell
pmid sentence
GSK3 phosphorylates FoxM1 on serine 474 which induces FoxM1 ubiquitination mediated by FBXW7.
Publications: 1 Organism: Homo Sapiens
+ TEAD1up-regulates quantity by expression img/indirect-activation.png transcriptional regulation FOXM1 0.274
Identifier Residue Sequence Organism Cell Line
SIGNOR-194371 Homo sapiens
pmid sentence
Yap directly induced the transcription of ccnd1 and foxm1, in cooperation with tead transcription factor.
Publications: 1 Organism: Homo Sapiens
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