| + |
CyclinB/CDK1 | up-regulates 
phosphorylation
|
FOXM1 |
0.775 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-216833 |
Ser251 |
MIQFAINsTERKRMT |
Homo sapiens |
|
| pmid |
sentence |
| 19737929 |
A conserved phosphorylation site within the forkhead domain of foxm1b is required for its activation by cyclin-cdk1the phosphorylation at ser-251 is critical for the activation of foxm1. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-216837 |
Thr611 |
ETLPISStPSKSVLP |
Homo sapiens |
|
| pmid |
sentence |
| 19737929 |
A conserved phosphorylation site within the forkhead domain of foxm1b is required for its activation by cyclin-cdk1further analysis reveals that the leu-641 residue within an lxl motif is required for the recruitment of the cyclin-cdk complex, and the thr-596 residue is a critical cdk1 phosphorylation site within the activation domain of foxm1b. Cdk-dependent phosphorylation stimulates the foxm1b transcriptional activity |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
CDK1 | up-regulates
phosphorylation
|
FOXM1 |
0.773 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-187876 |
Ser251 |
MIQFAINsTERKRMT |
Homo sapiens |
|
| pmid |
sentence |
| 19737929 |
A conserved phosphorylation site within the forkhead domain of foxm1b is required for its activation by cyclin-cdk1the phosphorylation at ser-251 is critical for the activation of foxm1. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-187880 |
Thr611 |
ETLPISStPSKSVLP |
Homo sapiens |
|
| pmid |
sentence |
| 19737929 |
A conserved phosphorylation site within the forkhead domain of foxm1b is required for its activation by cyclin-cdk1further analysis reveals that the leu-641 residue within an lxl motif is required for the recruitment of the cyclin-cdk complex, and the thr-596 residue is a critical cdk1 phosphorylation site within the activation domain of foxm1b. Cdk-dependent phosphorylation stimulates the foxm1b transcriptional activity |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
CHEK2 | up-regulates
phosphorylation
|
FOXM1 |
0.733 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-150746 |
Ser376 |
PLLPRVSsYLVPIQF |
Homo sapiens |
U2-OS Cell |
| pmid |
sentence |
| 17101782 |
Chk2 mediates stabilization of the foxm1 transcription factor to stimulate expression of dna repair genesthis phosphorylation of foxm1 on serine residue 361 caused increased stability of the foxm1 protein |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDK4 | up-regulates
phosphorylation
|
FOXM1 |
0.64 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-177251 |
Ser4 |
sPRRPLIL |
Homo sapiens |
|
| pmid |
sentence |
| 22094256 |
We identified the forkhead box m1 (foxm1) transcription factor as a common critical phosphorylation target. Cdk4/6 stabilize and activate foxm1these data identify five overlapping in vivo and in vitro cdk4/6 target sites in foxm1 (s4, s35, t611, t620 and t627) |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-177255 |
Thr611 |
ETLPISStPSKSVLP |
Homo sapiens |
|
| pmid |
sentence |
| 22094256 |
We identified the forkhead box m1 (foxm1) transcription factor as a common critical phosphorylation target. Cdk4/6 stabilize and activate foxm1these data identify five overlapping in vivo and in vitro cdk4/6 target sites in foxm1 (s4, s35, t611, t620 and t627) |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-177259 |
Thr620 |
SKSVLPRtPESWRLT |
Homo sapiens |
|
| pmid |
sentence |
| 22094256 |
We identified the forkhead box m1 (foxm1) transcription factor as a common critical phosphorylation target. Cdk4/6 stabilize and activate foxm1these data identify five overlapping in vivo and in vitro cdk4/6 target sites in foxm1 (s4, s35, t611, t620 and t627) |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-177263 |
Thr627 |
TPESWRLtPPAKVGG |
Homo sapiens |
|
| pmid |
sentence |
| 22094256 |
We identified the forkhead box m1 (foxm1) transcription factor as a common critical phosphorylation target. Cdk4/6 stabilize and activate foxm1these data identify five overlapping in vivo and in vitro cdk4/6 target sites in foxm1 (s4, s35, t611, t620 and t627) |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-177266 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22094256 |
We identified the forkhead box m1 (foxm1) transcription factor as a common critical phosphorylation target. Cdk4/6 stabilize and activate foxm1, thereby maintain expression of g1/s phase genes, suppress the levels of reactive oxygen species (ros), and protect cancer cells from senescence. |
|
| Publications: |
5 |
Organism: |
Homo Sapiens |
| + |
GSK3B | down-regulates quantity by destabilization 
phosphorylation
|
FOXM1 |
0.348 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277208 |
Ser474 |
S-->A |
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 26912724 |
GSK3 phosphorylates FoxM1 on serine 474 which induces FoxM1 ubiquitination mediated by FBXW7. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PLK1 | up-regulates
phosphorylation
|
FOXM1 |
0.722 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-187888 |
Ser730 |
VLDTMNDsLSKILLD |
Homo sapiens |
|
| pmid |
sentence |
| 19737929 |
It has been reported that plk1 could directly phosphorylate foxm1 at ser-715 and ser-724 for full activation and proper mitotic progression |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-187892 |
Ser739 |
SKILLDIsFPGLDED |
Homo sapiens |
|
| pmid |
sentence |
| 19737929 |
It has been reported that plk1 could directly phosphorylate foxm1 at ser-715 and ser-724 for full activation and proper mitotic progression |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
CDK2 | up-regulates activity
phosphorylation
|
FOXM1 |
0.761 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250731 |
Thr611 |
ETLPISStPSKSVLP |
|
U2-OS Cell |
| pmid |
sentence |
| 15024056 |
We demonstrated that FoxM1B transcriptional activity requires binding of either S-phase or M-phase Cdk-cyclin complexes to mediate efficient Cdk phosphorylation of the FoxM1B Thr 596 residue, which is essential for recruitment of p300/CBP coactivator proteins. |
|
| Publications: |
1 |
| + |
CHEK1 | up-regulates activity
phosphorylation
|
FOXM1 |
0.367 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280224 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23706767 |
In addition, upon treatment with genotoxic agents, the checkpoint kinases Chk1 and Chk2 also phosphorylate and activate FOXM1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SCF-FBW7 | down-regulates quantity by destabilization
ubiquitination
|
FOXM1 |
0.301 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277209 |
|
|
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 26912724 |
GSK3 phosphorylates FoxM1 on serine 474 which induces FoxM1 ubiquitination mediated by FBXW7. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FOXM1 | up-regulates activity
binding
|
CTNNB1 |
0.508 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277211 |
|
|
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 26912724 |
Nuclear FoxM1 then directly interacted with nuclear β‐catenin, which released β‐catenin from ICAT and enhanced recruitment of β‐catenin to the promoter of Wnt target gene, hence increasing the expression of Wnt target gene. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FOXM1 | up-regulates quantity by expression 
|
SLC27A2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260414 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31949772 |
FOXM1 as a prognostic biomarker promotes endometrial cancer progression via transactivation of SLC27A2 expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SRC | up-regulates activity
phosphorylation
|
FOXM1 |
0.321 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279117 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19665017 |
Hence, c-Src-dependent phosphorylation of MPP2 could be part of a negative feedback loop within the circuitry that modulates c-Src activity by MPP2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TEAD1 | up-regulates quantity by expression
transcriptional regulation
|
FOXM1 |
0.27 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-194371 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22286761 |
Yap directly induced the transcription of ccnd1 and foxm1, in cooperation with tead transcription factor. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HIPK2 | up-regulates activity
phosphorylation
|
FOXM1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278944 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30609136 |
In conclusion, the phosphorylation of FOXM1 by HIPK2 can promote FOXM1 transcription activity and cell proliferation in RCC, thus, indicating a potential mechanism for the treatment of human RCC in the future. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
USP5 | up-regulates quantity by stabilization
deubiquitination
|
FOXM1 |
0.344 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277210 |
|
|
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 26912724 |
Wnt signaling activation inhibits FoxM1 phosphorylation by GSK3-Axin complex and leads to interaction between FoxM1 and deubiquitinating enzyme USP5, thereby deubiquitination and stabilization of FoxM1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MELK | up-regulates activity
phosphorylation
|
FOXM1 |
0.494 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278412 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23404835 |
MELK Activates FOXM1 Transcriptional Activity Leading to Upregulation of Mitotic Gene Expression.|The autoradiogram clearly shows in vitro phosphorylation of FOXM1 by MELK and CDK2 and cyclinA. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
FOXM1
- 
- 