| + |
MAPK1 | up-regulates 
phosphorylation
|
GRB10 |
0.365 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-138163 |
Ser150 |
PELCGPGsPPVLTPG |
Homo sapiens |
|
| pmid |
sentence |
| 15952796 |
We show that grb10 is a direct substrate of the p42/44 mitogen-activated protein kinase (mapk)we identified ser(150), ser(418), and ser(476) of human grb10zeta as mapk-mediated in vitro phosphorylation sites. Replacing ser(150) and ser(476) with alanines reduced the inhibitory effect of human grb10zeta on insulin-stimulated irs1 tyrosine phosphorylation. Taken together, our findings suggest that phosphorylation of the adaptor protein may provide a feedback inhibitory mechanism by which grb10 regulates insulin signaling. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-138167 |
Ser476 |
MNILGSQsPLHPSTL |
Homo sapiens |
|
| pmid |
sentence |
| 15952796 |
We show that grb10 is a direct substrate of the p42/44 mitogen-activated protein kinase (mapk)we identified ser(150), ser(418), and ser(476) of human grb10zeta as mapk-mediated in vitro phosphorylation sites. Replacing ser(150) and ser(476) with alanines reduced the inhibitory effect of human grb10zeta on insulin-stimulated irs1 tyrosine phosphorylation. Taken together, our findings suggest that phosphorylation of the adaptor protein may provide a feedback inhibitory mechanism by which grb10 regulates insulin signaling. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
MAPK3 | up-regulates
phosphorylation
|
GRB10 |
0.296 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-138171 |
Ser150 |
PELCGPGsPPVLTPG |
Homo sapiens |
|
| pmid |
sentence |
| 15952796 |
Phosphorylation of grb10 by mitogen-activated protein kinase: identification of ser150 and ser476 of human grb10zeta as major phosphorylation sitesreplacing ser(150) and ser(476) with alanines reduced the inhibitory effect of human grb10zeta on insulin-stimulated irs1 tyrosine phosphorylation |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-138175 |
Ser476 |
MNILGSQsPLHPSTL |
Homo sapiens |
|
| pmid |
sentence |
| 15952796 |
Phosphorylation of grb10 by mitogen-activated protein kinase: identification of ser150 and ser476 of human grb10zeta as major phosphorylation sitesreplacing ser(150) and ser(476) with alanines reduced the inhibitory effect of human grb10zeta on insulin-stimulated irs1 tyrosine phosphorylation |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
MAPK3 |
phosphorylation
|
GRB10 |
0.296 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249406 |
Ser418 |
QQRKALLsPFSTPVR |
in vitro |
|
| pmid |
sentence |
| 15952796 |
We identified Ser150, Ser418, and Ser476 of human Grb10 as MAPK-mediated in vitro phosphorylation sites. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
MAPK1 |
phosphorylation
|
GRB10 |
0.365 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249405 |
Ser418 |
QQRKALLsPFSTPVR |
in vitro |
|
| pmid |
sentence |
| 15952796 |
We identified Ser150, Ser418, and Ser476 of human Grb10 as MAPK-mediated in vitro phosphorylation sites. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
FYN | down-regulates 
phosphorylation
|
GRB10 |
0.372 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-78702 |
Tyr67 |
NASLESLySACSMQS |
Homo sapiens |
|
| pmid |
sentence |
| 10871840 |
Grb10 tyrosine phosphorylation was stimulated by expression of constitutively active src or fyn in cells and by incubation with purified src or fyn in vitro. The insulin stimulated or src/fyn-mediated tyrosine phosphorylation in vivo was significantly reduced when grb10 tyrosine 67 was changed to glycine. This mutant form of grb10 bound with higher affinity to the ir in cells than that of the wild-type protein, suggesting that tyrosine phosphorylation of grb10 may normally negatively regulate its binding to the ir. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SRC | down-regulates
phosphorylation
|
GRB10 |
0.437 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-78706 |
Tyr67 |
NASLESLySACSMQS |
Homo sapiens |
|
| pmid |
sentence |
| 10871840 |
Grb10 tyrosine phosphorylation was stimulated by expression of constitutively active src or fyn in cells and by incubation with purified src or fyn in vitro. The insulin stimulated or src/fyn-mediated tyrosine phosphorylation in vivo was significantly reduced when grb10 tyrosine 67 was changed to glycine. This mutant form of grb10 bound with higher affinity to the ir in cells than that of the wild-type protein, suggesting that tyrosine phosphorylation of grb10 may normally negatively regulate its binding to the ir. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ERK1/2 | up-regulates
phosphorylation
|
GRB10 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270178 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15952796 |
Phosphorylation of grb10 by mitogen-activated protein kinase: identification of ser150 and ser476 of human grb10zeta as major phosphorylation sitesreplacing ser(150) and ser(476) with alanines reduced the inhibitory effect of human grb10zeta on insulin-stimulated irs1 tyrosine phosphorylation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, FLT3 in AML, FLT3-ITD signaling |
| + |
Gbeta | up-regulates
phosphorylation
|
GRB10 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270077 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15952796 |
Phosphorylation of grb10 by mitogen-activated protein kinase: identification of ser150 and ser476 of human grb10zeta as major phosphorylation sitesreplacing ser(150) and ser(476) with alanines reduced the inhibitory effect of human grb10zeta on insulin-stimulated irs1 tyrosine phosphorylation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GRB10 | up-regulates activity
binding
|
PI3K |
0.328 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255946 |
|
|
Mus musculus |
BA/F3 Cell |
| pmid |
sentence |
| 23246379 |
Grb10 transduces signal from FLT3 by direct interaction with p85 and Ba/F3-FLT3-ITD cells expressing Grb10 exhibits higher STAT5 activation |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Acute Myeloid Leukemia, FLT3 in AML, FLT3-ITD signaling |
| + |
14-3-3 | up-regulates
binding
|
GRB10 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-134198 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15722337 |
The interaction of phosphorylated grb10 with 14-3-3 may lead to the translocation of grb10 back to the cytosol |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GIGYF2 | up-regulates activity
binding
|
GRB10 |
0.582 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260057 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 20670374 |
We demonstrated that, in cultured cells and mammalian brains, GIGYF2 interacts and colocalises with Grb10, promoting ligand‐induced ubiquitination of IGF‐1R, and thereby regulates receptor degradation |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
GRB10 | down-regulates
binding
|
INSR |
0.673 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-174065 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21659604 |
Grb10 negatively regulates growth factor signaling. It binds the insulin and insulin-like growth factor 1 (igf-1) receptors;mice without grb10 are larger and exhibit enhanced insulin sensitivity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RET | up-regulates
binding
|
GRB10 |
0.559 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-41699 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8631863 |
Grb7 and grb10, likely relay signals emanating from ret to other, as yet, unidentified targets within the cell |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GRB10 | up-regulates activity
binding
|
PIK3R1 |
0.393 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255945 |
|
|
Mus musculus |
BA/F3 Cell |
| pmid |
sentence |
| 23246379 |
Grb10 transduces signal from FLT3 by direct interaction with p85 and Ba/F3-FLT3-ITD cells expressing Grb10 exhibits higher STAT5 activation |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
GRB10 | down-regulates
binding
|
IGF1R |
0.75 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-174062 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21659604 |
Grb10 negatively regulates growth factor signaling. It binds the insulinand insulin-like growth factor 1 (igf-1) receptors, and mice without grb10 are larger and exhibit enhanced insulin sensitivity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MTOR | up-regulates
phosphorylation
|
GRB10 |
0.407 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-174071 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21659604 |
The adaptor protein grb10 was identified as an mtorc1 substrate that mediates the phosphoinositide 3-kinase. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, FLT3 in AML, FLT3-ITD signaling |
| + |
FLT3 | up-regulates activity
binding
|
GRB10 |
0.356 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255947 |
|
|
Mus musculus |
BA/F3 Cell |
| pmid |
sentence |
| 23246379 |
These results suggest that Grb10 binds to both normal and oncogenic FLT3 and induces PI3K–Akt and STAT5 signaling pathways resulting in an enhanced proliferation, survival and colony formation of hematopoietic cells. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Acute Myeloid Leukemia, FLT3 in AML, FLT3-ITD signaling |
| + |
mTORC1 | up-regulates
phosphorylation
|
GRB10 |
0.353 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217063 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21659604 |
The adaptor protein grb10 was identified as an mtorc1 substrate that mediates the phosphoinositide 3-kinase. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
GRB10
- 
- 