3.0
Summary
| Name |  NFATC4View Modifications |
| Full Name | Nuclear factor of activated T-cells, cytoplasmic 4 |
| Synonyms | NF-ATc4, NFATc4, T-cell transcription factor NFAT3, NF-AT3 | NFAT3 |
| Primary ID | Q14934 |
| Links |  -  -  |
| Type | protein |
| Relations | 17 |
| Function | Ca(2+)-regulated transcription factor that is involved in several processes, including the development and function of the immune, cardiovascular, musculoskeletal, and nervous systems (PubMed:7749981, PubMed:11514544, PubMed:11997522, PubMed:17875713, PubMed:17213202, PubMed:18668201, PubMed:25663301). Involved in T-cell activation, stimulating the transcription of cytokine genes, including that of IL2 and IL4 (PubMed:7749981, PubMed:18668201, PubMed:18347059). Along with NFATC3, involved in embryonic heart development. Involved in mitochondrial energy metabolism required for cardiac morphogenesis and function (By similarity). Transactivates many genes involved in the cardiovascular system, including AGTR2, NPPB/BNP (in synergy with GATA4), NPPA/ANP/ANF and MYH7/beta-MHC (By similarity). Involved in the regulation of adult hippocampal neurogenesis. Involved in BDNF-driven pro-survival signaling in hippocampal adult-born neurons. Involved in the formation of long-term spatial memory and long-term potentiation (By similarity). In cochlear nucleus neurons, may play a role in deafferentation-induced apoptosis during the developmental critical period, when auditory neurons depend on afferent input for survival (By similarity). Binds to and activates the BACE1/Beta-secretase 1 promoter, hence may regulate the proteolytic processing of the amyloid precursor protein (APP) (PubMed:25663301). Plays a role in adipocyte differentiation (PubMed:11997522). May be involved in myoblast differentiation into myotubes (PubMed:17213202). Binds the consensus DNA sequence 5'-GGAAAAT-3' (Probable). In the presence of CREBBP, activates TNF transcription (PubMed:11514544). Binds to PPARG gene promoter and regulates its activity (PubMed:11997522). Binds to PPARG and REG3G gene promoters (By similarity). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | p38 | down-regulates 
phosphorylation
|
NFATC4 | 0.2 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | MAPK14 | down-regulates activity
phosphorylation
|
NFATC4 | 0.411 |
| Publications: | 2 | Organism: | Cricetulus Griseus | |
| + | RPS6KA3 | up-regulates 
phosphorylation
|
NFATC4 | 0.394 |
| Publications: | 5 | Organism: | Mus Musculus, Homo Sapiens | |
| Tissue: | Muscle, Skeletal Muscle, Myotube | |||
| + | MAPK1 | up-regulates
phosphorylation
|
NFATC4 | 0.287 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MAPK3 | up-regulates
phosphorylation
|
NFATC4 | 0.294 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | Gbeta | up-regulates
phosphorylation
|
NFATC4 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | NFATC4 | up-regulates quantity by expression
transcriptional regulation
|
PTGS2 | 0.286 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | Calcineurin | up-regulates
dephosphorylation
|
NFATC4 | 0.551 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ERK1/2 | up-regulates
phosphorylation
|
NFATC4 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PPP3CA | up-regulates
dephosphorylation
|
NFATC4 | 0.56 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | NFATC4 | up-regulates quantity by expression
transcriptional regulation
|
GPC6 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |