Summary

Name NCOA2
Full Name Nuclear receptor coactivator 2
Synonyms NCoA-2, Class E basic helix-loop-helix protein 75, bHLHe75, Transcriptional intermediary factor 2, hTIF2 | BHLHE75, SRC2, TIF2
Primary ID Q15596
Links - -
Type protein
Relations 11
Pathways Prostate Cancer
Function Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues. Critical regulator of glucose metabolism regulation, acts as RORA coactivator to specifically modulate G6PC1 expression. Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3. Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-ARNTL/BMAL1 heterodimer (By similarity).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation NCOA2 0.249
Publications: 4 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding AR 0.896
Publications: 2 Organism: Homo Sapiens
Pathways:Prostate Cancer
+ up-regulates img/direct-activation.png binding RARA 0.611
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding RXRA 0.785
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PPARG 0.754
Publications: 1 Organism: Homo Sapiens
Pathways:Prostate Cancer
+ up-regulates activity img/direct-activation.png binding NR3C1 0.829
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation NCOA2 0.807
Publications: 1 Organism: Homo Sapiens