Summary

Name MAP3K11
Full Name Mitogen-activated protein kinase kinase kinase 11
Synonyms Mixed lineage kinase 3, Src-homology 3 domain-containing proline-rich kinase | MLK3, PTK1, SPRK
Primary ID Q16584
Links - -
Type protein
Relations 20
Function Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation PIN1 0.265
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MAP2K4 0.609
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MAP2K4 0.609
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MAP3K11 0.555
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MAP3K11 0.2
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation MAP3K11 0.2
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation MAP3K11 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation MAP3K11 0.409
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MAP3K11 0.2
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation MAP3K11 0.342
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MAP3K11 0.309
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png MAPK8 0.61
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding MAP3K11 0.517
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MAP2K3 0.47
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation MAP3K11 0.309
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png MAPK9 0.33
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding MAP3K11 0.536
Publications: 1 Organism: Homo Sapiens
Tissue: Brain