| + |
MAP3K11 | up-regulates activity 
phosphorylation
|
PAK1 |
0.3 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279418 |
Ser133 |
DVLEFYNsKKTSNSQ |
Homo sapiens |
|
| pmid |
sentence |
| 30664689 |
Although, MLK3 can phosphorylate PAK1 on Ser133 and Ser204 sites, PAK1S133A mutant is constitutively active, whereas, PAK1S204A is not activated by MLK3.|MLK3 was able to directly phosphorylate PAK1 on two Serine residues of which Ser204 is critical for MLK3-induced PAK1 activation and downstream functions. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279417 |
Ser204 |
TKSVYTRsVIEPLPV |
Homo sapiens |
|
| pmid |
sentence |
| 30664689 |
Although, MLK3 can phosphorylate PAK1 on Ser133 and Ser204 sites, PAK1S133A mutant is constitutively active, whereas, PAK1S204A is not activated by MLK3.|MLK3 was able to directly phosphorylate PAK1 on two Serine residues of which Ser204 is critical for MLK3-induced PAK1 activation and downstream functions. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
MAP3K11 | up-regulates
phosphorylation
|
PIN1 |
0.26 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-205586 |
Ser138 |
QKPFEDAsFALRTGE |
Homo sapiens |
|
| pmid |
sentence |
| 25519816 |
Here we demonstrate that mixed-lineage kinase 3 (mlk3), a map3k family member, phosphorylates pin1 on a ser138 site to increase its catalytic activity and nuclear translocation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAP3K11 | up-regulates
phosphorylation
|
MAP2K4 |
0.639 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-128420 |
Ser257 |
ISGQLVDsIAKTRDA |
Homo sapiens |
|
| pmid |
sentence |
| 15328343 |
These data suggest that mlk-3 phosphorylates sek1 directly and that it does so specifically on those residues known to activate sek1 in vivo. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-75836 |
Thr261 |
LVDSIAKtRDAGCRP |
Homo sapiens |
|
| pmid |
sentence |
| 10727406 |
These data suggest that mlk-3 phosphorylates sek1 directly and that it does so specifically on those residues known to activate sek1 in vivo. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
MAP3K11 | up-regulates activity
phosphorylation
|
MAP2K4 |
0.639 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-48574 |
Ser257 |
ISGQLVDsIAKTRDA |
Homo sapiens |
COS-1 Cell |
| pmid |
sentence |
| 9003778 |
These data suggest that mlk-3 phosphorylates sek1 directly and that it does so specifically on those residues known to activate sek1 in vivo. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAP4K1 | up-regulates
phosphorylation
|
MAP3K11 |
0.59 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-83415 |
Ser281 |
WHKTTQMsAAGTYAW |
Homo sapiens |
|
| pmid |
sentence |
| 11053428 |
Hpk1 also phosphorylated mlk-3 activation loop in vitro, and ser281 was found to be the major phosphorylation site, indicating that hpk1 also activates mlk-3 via phosphorylation of the kinase activation loop. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAP3K11 | up-regulates
phosphorylation
|
MAP3K11 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-83407 |
Ser281 |
WHKTTQMsAAGTYAW |
Homo sapiens |
|
| pmid |
sentence |
| 11053428 |
These residues within the activation loop are critical for mlk-3 autophosphorylation and activation. In addition, when the thr277 and ser281 residues were mutated to negatively charged glutamic acid to mimic phosphorylated serine/threonine residues, the resulting mutants were fully functional, implying that these two residues may serve as the autophosphorylation sites. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-83411 |
Thr277 |
LAREWHKtTQMSAAG |
Homo sapiens |
|
| pmid |
sentence |
| 11053428 |
These residues within the activation loop are critical for mlk-3 autophosphorylation and activation. In addition, when the thr277 and ser281 residues were mutated to negatively charged glutamic acid to mimic phosphorylated serine/threonine residues, the resulting mutants were fully functional, implying that these two residues may serve as the autophosphorylation sites. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
CDK1 | down-regulates activity 
phosphorylation
|
MAP3K11 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277603 |
Ser548 |
GQAWGRQsPRRLEDS |
in vitro |
|
| pmid |
sentence |
| 35843311 |
Using in vitro kinase assays and phosphomutants, we determined that CDK1 phosphorylates MLK3 on Ser548 and decreases MLK3 activity during mitosis, whereas CDK2 phosphorylates MLK3 on Ser770 and increases MLK3 activity during G1/S and G2 phases. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
AKT | down-regulates
phosphorylation
|
MAP3K11 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-96062 |
Ser674 |
PGRERGEsPTTPPTP |
Homo sapiens |
Neuron |
| pmid |
sentence |
| 12458207 |
Negative regulation of mixed lineage kinase 3 by protein kinase b/akt leads to cell survivalthe expression of activated akt1 inhibits mlk3-mediated cell death in a manner dependent on serine 674 phosphorylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AKT1 | down-regulates
phosphorylation
|
MAP3K11 |
0.392 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252592 |
Ser674 |
PGRERGEsPTTPPTP |
Homo sapiens |
Neuron |
| pmid |
sentence |
| 12458207 |
Negative regulation of mixed lineage kinase 3 by protein kinase b/akt leads to cell survivalthe expression of activated akt1 inhibits mlk3-mediated cell death in a manner dependent on serine 674 phosphorylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDK2 | up-regulates activity
phosphorylation
|
MAP3K11 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277604 |
Ser770 |
LISRPRPsPLRSRID |
in vitro |
|
| pmid |
sentence |
| 35843311 |
Using in vitro kinase assays and phosphomutants, we determined that CDK1 phosphorylates MLK3 on Ser548 and decreases MLK3 activity during mitosis, whereas CDK2 phosphorylates MLK3 on Ser770 and increases MLK3 activity during G1/S and G2 phases. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
GSK3B | up-regulates activity
phosphorylation
|
MAP3K11 |
0.329 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279616 |
Ser789 |
VSAGPRPsPLPSPQP |
Homo sapiens |
|
| pmid |
sentence |
| 20005250 |
Further, investigation revealed that MLK3 was phosphorylated at two residues Ser789 and Ser793 by GSK3beta.|When, these two sites on MLK3 were mutated to non-phosphorable Ala, the activation of MLK3 by GSK3\u03b2 was blocked, and neuronal cell death upon NGF withdrawal also prevented ( xref ). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276071 |
Ser789 |
VSAGPRPsPLPSPQP |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 17711861 |
The activation of MLK3 by GSK-3beta occurred via phosphorylation of MLK3 on two amino acid residues, Ser(789) and Ser(793), that are located within the C-terminal regulatory domain of MLK3. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279615 |
Ser793 |
PRPSPLPsPQPAPRR |
Homo sapiens |
|
| pmid |
sentence |
| 20005250 |
Further, investigation revealed that MLK3 was phosphorylated at two residues Ser789 and Ser793 by GSK3\u03b2 ( xref ).|When, these two sites on MLK3 were mutated to non-phosphorable Ala, the activation of MLK3 by GSK3\u03b2 was blocked, and neuronal cell death upon NGF withdrawal also prevented ( xref ). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276072 |
Ser793 |
PRPSPLPsPQPAPRR |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 17711861 |
The activation of MLK3 by GSK-3beta occurred via phosphorylation of MLK3 on two amino acid residues, Ser(789) and Ser(793), that are located within the C-terminal regulatory domain of MLK3. |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| + |
MAP4K4 | up-regulates activity
phosphorylation
|
MAP3K11 |
0.3 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277571 |
Thr738 |
EEEPRGGtVSPPPGT |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 34511598 |
The MAP4K4 and MLK3 associates with each other, and MAP4K4 phosphorylates MLK3 on Thr738 and increases MLK3 kinase activity and downstream signaling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAP3K11 | up-regulates activity
phosphorylation
|
GOLGA3 |
0.358 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279065 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14734651 |
In vitro kinase assays demonstrated that MLK3 directly phosphorylates golgin-160 in the N-terminal head region between residues 96 and 259. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAP3K11 | up-regulates activity
phosphorylation
|
MAP2K3 |
0.513 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-45788 |
|
|
Homo sapiens |
COS-1 Cell |
| pmid |
sentence |
| 9003778 |
Immunoprecipitated mlk-3 catalyzed the phosphorylation of sek1 in vitro, and co-transfected mlk-3 induced phosphorylation of sek1 and mkk3 at sites required for activation, suggesting direct regulation of these protein kinases. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAP3K11 | up-regulates activity
phosphorylation
|
MAP2K1 |
0.329 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280019 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12738796 |
Here we report that MLK3 can phosphorylate and activate MEK-1 directly in vitro and also can induce MEK phosphorylation on its activation sites in vivo in COS-7 cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK8IP3 | up-regulates
binding
|
MAP3K11 |
0.565 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-73909 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 10629060 |
These data demonstrate that jip3 interacts with proteins that can form a mapk signaling module, including jnk, mkk7, and mlk3jip3 increases mlk3-stimulated jnk activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Brain |
| + |
MAP3K11 | up-regulates 
|
MAPK8 |
0.641 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-45791 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9003778 |
The kinase-inactive mlk-3 failed to activate sapk, demonstraiting that mlk-3 catalytic activity is necessary for the induction of the sapk pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SH3RF1 | up-regulates
binding
|
MAP3K11 |
0.493 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-97006 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 12514131 |
Taken together, these findings support a model in which apoptotic stimuli or posh overexpression induce direct association between posh and inactive mlks. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAP3K11 | up-regulates
|
MAPK9 |
0.32 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-59884 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9733513 |
This scaffold protein selectively enhanced jnk activation by the mlk signaling pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK14 | down-regulates
phosphorylation
|
MAP3K11 |
0.301 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-166605 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20626350 |
Jnk and p38 mapk activation have antagonistic effects in many cases. From a mechanicistic point of view, the p38 mapk pathway can negatively regulate jnk activity at the level of map3ks, either by phosphorylating mlk3 or the tak1 regulatory subunit tab2 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
MAP3K11
- 
- 