3.0
Summary
| Name |  TET2View Modifications |
| Full Name | Methylcytosine dioxygenase TET2 |
| Synonyms | TET2_HUMAN | KIAA1546 |
| Primary ID | Q6N021 |
| Links |  -  -  |
| Type | protein |
| Relations | 12 |
| Pathways | Acute Myeloid Leukemia, DNMT3A in AML, AML-IDH/TET, IDH-TET in AML, miRNA in AML, NPM1_new, Rett syndrome |
| Inhibitors | (R)-2-hydroxyglutarate(2-) |
| Function | Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PRKAA1 | up-regulates quantity by stabilization 
phosphorylation
|
TET2 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | AMPK | up-regulates quantity by stabilization
phosphorylation
|
TET2 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Acute Myeloid Leukemia, IDH-TET in AML, NPM1_new | |||
| + | miR-29b | down-regulates quantity by repression 
post transcriptional regulation
|
TET2 | 0.4 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | AMPK | up-regulates activity
phosphorylation
|
TET2 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Acute Myeloid Leukemia, IDH-TET in AML, NPM1_new | |||
| + | ASXL2 | up-regulates quantity by expression 
transcriptional regulation
|
TET2 | 0.348 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Acute Myeloid Leukemia, IDH-TET in AML | |||
| + | miR-29c | down-regulates quantity by repression
post transcriptional regulation
|
TET2 | 0.4 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | 2-oxoglutarate(2-) | up-regulates activity
binding
|
TET2 | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Acute Myeloid Leukemia, DNMT3A in AML, AML-IDH/TET, IDH-TET in AML, NPM1_new | |||
| + | miR-29a | down-regulates quantity by repression
post transcriptional regulation
|
TET2 | 0.4 |
| Publications: | 1 | Organism: | Rattus Norvegicus | |
| Pathways: | Rett syndrome | |||
| + | TET2 | up-regulates
binding
|
OGT | 0.461 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | (R)-2-hydroxyglutarate(2-) | down-regulates activity
chemical inhibition
|
TET2 | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TET2 | down-regulates 
|
Proliferation | 0.7 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | AML-IDH/TET, Acute Myeloid Leukemia, DNMT3A in AML, AML-IDH/TET, IDH-TET in AML, miRNA in AML, NPM1_new | |||
| + | TET2 | up-regulates activity
binding
|
WT1 | 0.469 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | AML-IDH/TET, Acute Myeloid Leukemia, DNMT3A in AML, AML-IDH/TET, IDH-TET in AML, miRNA in AML, NPM1_new | |||