Summary

Name PREX2
Full Name Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein
Synonyms P-Rex2, PtdIns(3,4,5)-dependent Rac exchanger 2, DEP domain-containing protein 2 | DEPDC2
Primary ID Q70Z35
Links - -
Type protein
Relations 6
Function Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important mediator of Rac signaling, acting directly downstream of both G protein-coupled receptors and phosphoinositide 3-kinase.

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RHOA 0.418
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding PTEN 0.606
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor, catalytic activity RAC1 0.59
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding PREX2 0.606
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor CDC42 0.437
Publications: 1 Organism: Homo Sapiens