| + |
DUSP9 | down-regulates 
dephosphorylation, binding
|
MAPK1 |
0.683 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-176586 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21908610 |
In addition, although mutation of ser-58 to either alanine or glutamic acid does not affect the intrinsic catalytic activity of dusp9/mkp-4, phospho-mimetic (ser-58 to glu) substitution inhibits both the interaction of dusp9/mkp-4 with erk2 and p38? In vivo and its ability to dephosphorylate and inactivate these map kinases. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-176583 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21908610 |
Here we demonstrate that inactivation of both erk1/2 and p38_ by dusp9/mkp-4 is mediated by a conserved arginine-rich kinase interaction motif located within the amino-terminal non-catalytic domain of the protein. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
DUSP9 | down-regulates
binding
|
Gbeta |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269902 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21908610 |
Here we demonstrate that inactivation of both erk1/2 and p38_ by dusp9/mkp-4 is mediated by a conserved arginine-rich kinase interaction motif located within the amino-terminal non-catalytic domain of the protein. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DUSP9 | down-regulates
dephosphorylation
|
MAPK14 |
0.682 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-87150 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11988087 |
These properties define the ability of this enzyme to dephosphorylate and inactivate erk1/2 and p38a, but not jnk (c-jun n-terminal kinase) in vivo. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle |
| + |
DUSP9 | down-regulates
binding
|
MAPK3 |
0.686 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-176589 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21908610 |
Here we demonstrate that inactivation of both erk1/2 and p38_ by dusp9/mkp-4 is mediated by a conserved arginine-rich kinase interaction motif located within the amino-terminal non-catalytic domain of the protein. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DUSP9 | down-regulates
binding
|
ERK1/2 |
0.709 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269924 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21908610 |
Here we demonstrate that inactivation of both erk1/2 and p38_ by dusp9/mkp-4 is mediated by a conserved arginine-rich kinase interaction motif located within the amino-terminal non-catalytic domain of the protein. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
DUSP9
- 
- 