4.0
Summary
| Name |  MKNK2View Modifications |
| Full Name | MAP kinase-interacting serine/threonine-protein kinase 2 |
| Synonyms | MAP kinase signal-integrating kinase 2, MAPK signal-integrating kinase 2, Mnk2 | GPRK7, MNK2 |
| Primary ID | Q9HBH9 |
| Links |  -  -  |
| Type | protein |
| Relations | 8 |
| Inhibitors | Tomivosertib |
| Function | Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Isoform 1 displays a high basal kinase activity, but isoform 2 exhibits a very low kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As(2)O(3)-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | MKNK2 | up-regulates 
phosphorylation
|
EIF4E | 0.56 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MTOR | down-regulates activity 
phosphorylation
|
MKNK2 | 0.275 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MAPK1 | up-regulates
phosphorylation
|
MKNK2 | 0.6 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ERK1/2 | up-regulates
phosphorylation
|
MKNK2 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | Tomivosertib | down-regulates activity
chemical inhibition
|
MKNK2 | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MAPK3 | up-regulates
phosphorylation
|
MKNK2 | 0.518 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MAPK14 | up-regulates
phosphorylation
|
MKNK2 | 0.412 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | Gbeta | up-regulates
phosphorylation
|
MKNK2 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |