4.0
Summary
| Name |  NUP50View Modifications |
| Full Name | Nuclear pore complex protein Nup50 |
| Synonyms | 50 kDa nucleoporin, Nuclear pore-associated protein 60 kDa-like, Nucleoporin Nup50 | NPAP60L |
| Primary ID | Q9UKX7 |
| Links |  -  -  |
| Type | protein |
| Relations | 9 |
| Function | Component of the nuclear pore complex that has a direct role in nuclear protein import (PubMed:20016008). Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin-alpha:beta-cargo complex and importin recycling (PubMed:20016008). Interacts with regulatory proteins of cell cycle progression including CDKN1B (By similarity). This interaction is required for correct intracellular transport and degradation of CDKN1B (By similarity). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | ERK1/2 | down-regulates activity 
phosphorylation
|
NUP50 | 0.2 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | MAPK1 | down-regulates activity
phosphorylation
|
NUP50 | 0.2 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | CDK1 | down-regulates
phosphorylation
|
NUP50 | 0.444 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MAPK3 | down-regulates
phosphorylation
|
NUP50 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MAPK3 | down-regulates activity
phosphorylation
|
NUP50 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | NUP50 | form complex 
binding
|
NPC | 0.602 |
| Publications: | 1 | |||
| + | Gbeta | down-regulates
phosphorylation
|
NUP50 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |