| + |
RSPO2 | down-regulates quantity 
ubiquitination
|
FZD4 |
0.323 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260117 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22575959 |
Here we show that the cell-surface transmembrane E3 ubiquitin ligase zinc and ring finger 3 (ZNRF3) and its homologue ring finger 43 (RNF43) are negative feedback regulators of Wnt signalling. ZNRF3 is associated with the Wnt receptor complex, and inhibits Wnt signalling by promoting the turnover of frizzled and LRP6. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WNT5A | up-regulates activity 
binding
|
FZD4 |
0.729 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258954 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16602827 |
We show that in addition to its inhibitory function, Wnt5a can also activate beta-catenin signaling in the presence of the appropriate Frizzled receptor, Frizzled 4. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ZNRF3 | down-regulates quantity
ubiquitination
|
FZD4 |
0.542 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260115 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 22575959 |
Here we show that the cell-surface transmembrane E3 ubiquitin ligase zinc and ring finger 3 (ZNRF3) and its homologue ring finger 43 (RNF43) are negative feedback regulators of Wnt signalling. ZNRF3 is associated with the Wnt receptor complex, and inhibits Wnt signalling by promoting the turnover of frizzled and LRP6. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FZD4 | up-regulates activity
binding
|
DVL2 |
0.741 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258958 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27096005 |
Through study of FZD4 and its associated ligand Norrin, we report that a minimum of three residues distal to the KTXXXW motif in the C-terminal tail of Frizzled-4 are essential for DVL recruitment and robust Lef/Tcf-dependent transcriptional activation in response to Norrin. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-100274 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12958364 |
Endocytosis of frizzled 4 (fz4) in human embryonic kidney 293 cells was dependent on added wnt5a protein and was accomplished by the multifunctional adaptor protein beta-arrestin 2 (betaarr2), which was recruited to fz4 by binding to phosphorylated dvl2. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
FZD4 | up-regulates activity
binding
|
DVL1 |
0.595 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258955 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27096005 |
Through study of FZD4 and its associated ligand Norrin, we report that a minimum of three residues distal to the KTXXXW motif in the C-terminal tail of Frizzled-4 are essential for DVL recruitment and robust Lef/Tcf-dependent transcriptional activation in response to Norrin. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, FLT3-ITD in AML |
| + |
FLT3 | up-regulates quantity by expression 
transcriptional regulation
|
FZD4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261533 |
|
|
Mus musculus |
32D Cell |
| pmid |
sentence |
| 15650056 |
AML-typical Flt3 mutations induce the expression of Frizzled-4 on the mRNA and protein level, mimicking the effects of IL-3. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260121 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 15650056 |
Microarray analyses revealed higher mRNA expression of Frizzled-4, a receptor for Wnt ligands in 32D/Flt3-ITD cells. Findings were verified by quantitative realtime reverse transcription–polymerase chain reaction (RT-PCR) and on the protein level. |
|
| Publications: |
2 |
Organism: |
Mus Musculus |
| Pathways: | Acute Myeloid Leukemia, FLT3-ITD in AML |
| + |
FZD4 | up-regulates activity
binding
|
DVL3 |
0.57 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258961 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27096005 |
Through study of FZD4 and its associated ligand Norrin, we report that a minimum of three residues distal to the KTXXXW motif in the C-terminal tail of Frizzled-4 are essential for DVL recruitment and robust Lef/Tcf-dependent transcriptional activation in response to Norrin. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FZD4 | up-regulates activity
binding
|
LRP5 |
0.695 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258967 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25902418 |
Here we report that Wnt receptor Frizzled (Frz) and theco-receptors LRP5 and LRP6 (LRP5/6) directly interact with each other and this interaction is regulated by the LRP6 ectodomain. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FZD4 | up-regulates activity
binding
|
LRP6 |
0.635 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258964 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18077588 |
Here we show that both Fz and Dvl functions are critical for Wnt-induced Lrp6 phosphorylation through Fz-Lrp6 interaction. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
FZD4
- 
- 