| + |
WNT1 | up-regulates activity 
binding
|
FZD1 |
0.689 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-131568 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15578921 |
Wnt proteins bind to the frizzled receptors and lrp5/6 co-receptors, and through stabilizing the critical mediator betBeta-catenin, initiate a complex signaling cascade that plays an important role in regulating cell proliferation and differentiation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-198843 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22944199 |
Distinctly, wnt1 signals through fzd receptors 1 and 6 in the epaxial domain of the somite, to regulate myf5 expression via the canonical _-catenin pathway |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217827 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 16936075 |
Here, we report that the Wnt signal is transduced in muscle progenitor cells by at least two Frizzled (Fz) receptors (Fz1 and/or Fz6) |
|
| Publications: |
3 |
Organism: |
Homo Sapiens, Mus Musculus |
| Tissue: |
Muscle, Skeletal Muscle, Muscle |
| + |
WNT10B | up-regulates activity
binding
|
FZD1 |
0.651 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253511 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19008118 |
In mesenchymal precursor cells, Wnt10b (and Wnt10a) binding to frizzled (FZD1) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WNT3A | up-regulates activity
binding
|
FZD1 |
0.788 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-73036 |
|
|
Homo sapiens |
Myoblast |
| pmid |
sentence |
| 10601008 |
Ligands such as wnt1, wnt3a, and wnt8 couple the seventransmembrane domain receptor frizzled (fzd) and the single-membrane-spanning low-density receptor-related protein 5/6 (lrp5/6) to activate wnt?Beta-catenin signaling.All the frizzled genes studied have a complex and partially overlapping pattern of expression in different regions of the embryo, and many of them (fz1, 3, 7, 8 and 9) have specific expression in the epithelial somites as well as in the newly formed myotomes. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-169651 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 21078818 |
Ligands such as wnt1, wnt3a, and wnt8 couple the seventransmembrane domain receptor frizzled (fzd) and the single-membrane-spanning low-density receptor-related protein 5/6 (lrp5/6) to activate wnt?Beta-catenin signaling.All the frizzled genes studied have a complex and partially overlapping pattern of expression in different regions of the embryo, and many of them (fz1, 3, 7, 8 and 9) have specific expression in the epithelial somites as well as in the newly formed myotomes. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
FZD1 | up-regulates activity
binding
|
DVL2 |
0.665 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258952 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23151663 |
Upon ligand binding, DVL proteins are recruited to Frizzled receptors at the plasma membrane and co-recruit cytoplasmic transducers, such as Axin, CK1 and GSK3 binding protein (GBP), presumably along with their partners, to promote ?-catenin-dependent signalling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WNT10B | up-regulates
binding
|
FZD1 |
0.651 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-89134 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12055200 |
Inhibition of adipogenesis by wnt10b is likely mediated by wnt receptors, frizzled 1, 2, and/or 5, and co-receptors low density lipoprotein receptor-related proteins 5 and 6 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FZD1 | down-regulates 
|
PPARG |
0.281 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-80598 |
|
|
Homo sapiens |
Myoblast |
| pmid |
sentence |
| 10937998 |
Wnt signaling maintains preadipocytes in an undifferentiated state through inhibition of the adipogenic transcription factors ccaat/enhancer binding protein alpha (c/ebpalpha) and peroxisome proliferator- activated receptor gamma (ppargamma) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WNT7B | up-regulates
binding
|
FZD1 |
0.656 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-137931 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15923619 |
Wnt7b can bind to fzd1 and -10 on the cell surface and cooperatively activate canonical wnt signaling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Lung, Smooth Muscle |
| + |
FZD1 | up-regulates activity
binding
|
DVL1 |
0.676 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253512 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22944199 |
When canonical wnts bind to their respective fzd receptors, heterotrimeric g-proteins and dsh get activated and lead to the recruitment of axin to the fzd co-receptor lrp. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FZD1 | up-regulates activity
binding
|
DVL3 |
0.643 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258953 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23151663 |
Upon ligand binding, DVL proteins are recruited to Frizzled receptors at the plasma membrane and co-recruit cytoplasmic transducers, such as Axin, CK1 and GSK3 binding protein (GBP), presumably along with their partners, to promote ?-catenin-dependent signalling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NME1 | down-regulates quantity by repression
transcriptional regulation
|
FZD1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255162 |
|
|
Homo sapiens |
MDA-MB-435 Cell |
| pmid |
sentence |
| 17671192 |
To elucidate the molecular mechanism of Nm23-H1 motility suppression, expression microarray analysis of an MDA-MB-435 cancer cell line overexpressing wild-type Nm23-H1 was done and cross-compared with expression profiles from lines expressing the P96S and S120G mutants. Nine genes, MET, PTN, SMO, FZD1, L1CAM, MMP2, NETO2, CTGF, and EDG2, were down-regulated by wild-type but not by mutant Nm23-H1 expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FZD1 | down-regulates
|
CEBPA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-80595 |
|
|
Homo sapiens |
Myoblast |
| pmid |
sentence |
| 10937998 |
Wnt signaling maintains preadipocytes in an undifferentiated state through inhibition of the adipogenic transcription factors ccaat/enhancer binding protein alpha (c/ebpalpha) and peroxisome proliferator- activated receptor gamma (ppargamma) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
FZD1
- 
- 