| + |
SFRP1 | down-regulates 
binding
|
WNT1 |
0.782 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-71423 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10523516 |
Frp inhibits wnt signaling through interactions with wnt and/or formation of nonfunctional complexes with the frizzled receptor. here we demonstrate that frza, a sfrp that is highly expressed in vascular endothelium and a variety of epithelium, specifically binds to wnt-1 protein, but not wnt-5a protein, and modulates wnt-1 signaling. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-67806 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 10347172 |
Frp inhibits wnt signaling through interactions with wnt and/or formation of nonfunctional complexes with the frizzled receptor. here we demonstrate that frza, a sfrp that is highly expressed in vascular endothelium and a variety of epithelium, specifically binds to wnt-1 protein, but not wnt-5a protein, and modulates wnt-1 signaling. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | WNT Signaling |
| + |
WNT1 | up-regulates activity 
binding
|
FZD1 |
0.698 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217827 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 16936075 |
Here, we report that the Wnt signal is transduced in muscle progenitor cells by at least two Frizzled (Fz) receptors (Fz1 and/or Fz6) |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-198843 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22944199 |
Distinctly, wnt1 signals through fzd receptors 1 and 6 in the epaxial domain of the somite, to regulate myf5 expression via the canonical _-catenin pathway |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-131568 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15578921 |
Wnt proteins bind to the frizzled receptors and lrp5/6 co-receptors, and through stabilizing the critical mediator betBeta-catenin, initiate a complex signaling cascade that plays an important role in regulating cell proliferation and differentiation. |
|
| Publications: |
3 |
Organism: |
Mus Musculus, Homo Sapiens |
| Tissue: |
Muscle, Muscle, Skeletal Muscle |
| + |
WNT1 | up-regulates
binding
|
RYK |
0.708 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-129577 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15454084 |
Mammalian ryk is a wnt coreceptor required for stimulation of neurite outgrowth |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WNT1 | up-regulates
binding
|
FZD8 |
0.724 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-109250 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11448771 |
Wnt signaling is mediated by the frizzled (fz) family of seven-pass transmembrane receptors that bind wnt via the conserved amino-terminal cysteine-rich domain (crd) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FRZB | down-regulates
binding
|
WNT1 |
0.515 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-51762 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9326585 |
We and others demonstrated that fzb-1 blocks wnt-1 and xwnt-8 signaling in xenopus embryos, |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Kidney |
| + |
WNT1 | up-regulates activity
binding
|
FZD6 |
0.689 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-198846 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22944199 |
Distinctly, wnt1 signals through fzd receptors 1 and 6 in the epaxial domain of the somite, to regulate myf5 expression via the canonical bcatenin pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Skeletal Muscle |
| + |
WNT1 | up-regulates activity 
|
MYF5 |
0.335 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-198849 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 22944199 |
In explant cultures of mouse paraxial mesoderm, Wnt1 induced expression of the MRF Myf5, whereas Wnt7a or Wnt6 preferentially activated the MRF MyoD |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-60285 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 9753670 |
Differential activation of Myf5 and MyoD by different Wnts in explants of mouse paraxial mesoderm and the later activation of myogenesis in the absence of Myf5 |
|
| Publications: |
2 |
Organism: |
Mus Musculus |
| Tissue: |
Muscle, Skeletal Muscle |
| Pathways: | WNT Signaling and Myogenesis |
| + |
hsa-miR-148a-3p | down-regulates quantity by repression
post transcriptional regulation
|
WNT1 |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278851 |
|
|
Homo sapiens |
CAPAN-2 Cell |
| pmid |
sentence |
| 33026174 |
These findings indicated that miR-148a-3p could inhibit Wnt/β-catenin signalling pathway by directly targeting Wnt1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WNT1 | up-regulates activity
binding
|
Frizzled |
0.765 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255649 |
|
|
|
|
| pmid |
sentence |
| 18697834 |
Wnt1, Wnt3a and Wnt5a all induced a statistically greater degree of proliferation than control cells |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253126 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 16936075 |
Here, we report that the Wnt signal is transduced in muscle progenitor cells by at least two Frizzled (Fz) receptors (Fz1 and/or Fz6) |
|
| Publications: |
2 |
Organism: |
, Mus Musculus |
| Tissue: |
Muscle |
| Pathways: | WNT Signaling, WNT Signaling and Myogenesis |
| + |
WNT1 | up-regulates activity
binding
|
LRP5 |
0.786 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-169645 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 21078818 |
Ligands such as wnt1, wnt3a, and wnt8 couple the seventransmembrane domain receptor frizzled (fzd) and the single-membrane-spanning low-density receptor-related protein 5/6 (lrp5/6) to activate wnt?Beta-catenin signaling. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-131574 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15578921 |
Wnt proteins bind to the frizzled receptors and lrp5/6 co-receptors, and through stabilizing the critical mediator betBeta-catenin, initiate a complex signaling cascade that plays an important role in regulating cell proliferation and differentiation. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Colorectal Carcinoma, WNT Signaling, WNT Signaling and Myogenesis |
| + |
WNT1 | up-regulates activity
binding
|
FZD3 |
0.625 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-131571 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15578921 |
Wnt proteins bind to the frizzled receptors and lrp5/6 co-receptors, and through stabilizing the critical mediator betBeta-catenin, initiate a complex signaling cascade that plays an important role in regulating cell proliferation and differentiation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SOSTDC1 | down-regulates activity 
|
WNT1 |
0.275 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242704 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 22829579 |
Our laboratory identified an almost twofold upregulation of sclerostin domain-containing 1 (Sostdc1; also referred to as WISE, USAG-1, ectodin), a dual Bmp/Wnt inhibitor, in postnatal day (P)1 pancreata from transgenic mice misexpressing hepatocyte nuclear factor (Hnf)6 in islet endocrine cells. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
ERG | up-regulates quantity by expression
transcriptional regulation
|
WNT1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261597 |
|
|
Mus musculus |
LNCaP Cell |
| pmid |
sentence |
| 23913826 |
Interestingly, our data showed that ERG drastically induced Wnt ligand gene expression. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
hsa-miR-148a-5p | down-regulates quantity by repression
post transcriptional regulation
|
WNT1 |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278850 |
|
|
Homo sapiens |
MDA-MB-231 Cell |
| pmid |
sentence |
| 26707142 |
We found that miR-148a could inhibit the migration and invasion of breast cancer cells by directly targeting WNT-1 and inhibiting the activation of Wnt/β-catenin pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FASN | up-regulates activity
|
WNT1 |
0.249 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242881 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18838960 |
Overexpression of fatty acid synthase is associated with palmitoylation of Wnt1 and cytoplasmic stabilization of beta-catenin in prostate cancer |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
hsa-miR-22-5p | down-regulates quantity by repression
post transcriptional regulation
|
WNT1 |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278848 |
|
|
Homo sapiens |
MGC-803 Cell |
| pmid |
sentence |
| 23851184 |
MiR-200b and miR-22 directly targeted Wnt-1 gene and synergistically inhibited Wnt signaling pathway. The miR-200b and miR-22 have putative binding sites in the 3' UTRs of Wnt1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
hsa-miR-200b-5p | down-regulates quantity by repression
post transcriptional regulation
|
WNT1 |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278849 |
|
|
Homo sapiens |
MGC-803 Cell |
| pmid |
sentence |
| 23851184 |
MiR-200b and miR-22 directly targeted Wnt-1 gene and synergistically inhibited Wnt signaling pathway. The miR-200b and miR-22 have putative binding sites in the 3' UTRs of Wnt1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WNT1 | up-regulates
|
CTNNB1 |
0.74 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-85760 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 11149923 |
Wnt-1 signaling inhibited the cytochrome c release and the subsequent caspase-9 activation induced by chemotherapeutic drugs, including both vincristine and vinblastine. Furthermore, we found that wnt-1-mediated cell survival was dependent on the activation of beta-catenin/t cell factor (tcf) transcription |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| Pathways: | Colorectal Carcinoma, WNT Signaling, WNT Signaling and Myogenesis |
| + |
WNT1 | up-regulates activity
binding
|
LRP6 |
0.825 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-169648 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 21078818 |
Ligands such as wnt1, wnt3a, and wnt8 couple the seventransmembrane domain receptor frizzled (fzd) and the single-membrane-spanning low-density receptor-related protein 5/6 (lrp5/6) to activate wnt?Beta-catenin signaling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | WNT Signaling, WNT Signaling and Myogenesis |
| + |
WNT1 | up-regulates activity
|
PRKACA |
0.268 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-176572 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21902831 |
Wnt1 and wnt7a stimulation of precursor cells activates protein kinase a (pka), which, through the phosphorylation of creb, induces the expression of the myogenic transcription factors myf5, myod and pax3, resulting in the myogenic commitment of embryonic precursors. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Skeletal Muscle |
| Pathways: | WNT Signaling, WNT Signaling and Myogenesis |
4.0
WNT1
- 
- 