| + |
DYRK3 | down-regulates activity 
phosphorylation
|
NCOA3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275451 |
Ser1330 |
PAFGRVSsPPNAMMS |
Homo sapiens |
Hepatoma Cell Line |
| pmid |
sentence |
| 31066068 |
Mechanistically, Dyrk3 directly phosphorylated NCOA3 at Ser-1330, disrupting its binding to ATF4 and thereby causing the inhibition of ATF4 transcriptional activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK14 | up-regulates activity 
phosphorylation
|
NCOA3 |
0.524 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250103 |
Ser505 |
SPVAGVHsPMASSGN |
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 15383283 |
P38 MAPK and JNK can phosphorylate multiple sites on SRC-3, including S505, S543, S860, and S867. Our results suggest that several kinases are important for phosphorylating SRC-3 and enhancing its interaction with DNA-dependent transcription factors and other coactivators. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250104 |
Ser543 |
SLLSTLSsPGPKLDN |
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 15383283 |
P38 MAPK and JNK can phosphorylate multiple sites on SRC-3, including S505, S543, S860, and S867. Our results suggest that several kinases are important for phosphorylating SRC-3 and enhancing its interaction with DNA-dependent transcription factors and other coactivators. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250105 |
Ser860 |
NRAVSLDsPVSVGSS |
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 15383283 |
P38 MAPK and JNK can phosphorylate multiple sites on SRC-3, including S505, S543, S860, and S867. Our results suggest that several kinases are important for phosphorylating SRC-3 and enhancing its interaction with DNA-dependent transcription factors and other coactivators. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250106 |
Ser867 |
SPVSVGSsPPVKNIS |
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 15383283 |
P38 MAPK and JNK can phosphorylate multiple sites on SRC-3, including S505, S543, S860, and S867. Our results suggest that several kinases are important for phosphorylating SRC-3 and enhancing its interaction with DNA-dependent transcription factors and other coactivators. |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| + |
GSK3A | down-regulates quantity by destabilization
phosphorylation
|
NCOA3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276067 |
Ser509 |
GVHSPMAsSGNTGNH |
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 17574025 |
GSK3 Phosphorylates SRC-3 on S505.In this report, we identified GSK3 as a kinase that phosphorylates SRC-3 on S505 and demonstrated that this phosphorylation modulates SRC-3 transcriptional function and turnover. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CSNK1D | up-regulates
phosphorylation
|
NCOA3 |
0.285 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-184946 |
Ser601 |
SDKESKEsSVEGAEN |
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 19339517 |
In this study, we show that both eralpha and aib1 are substrates for ck1delta in vitro, and identify a novel aib1 phosphorylation site (s601) targeted by ck1delta, significant for the co-activator function of aib1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CyclinB/CDK1 | down-regulates
phosphorylation
|
NCOA3 |
0.314 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-216892 |
Ser728 |
VVKQEQLsPKKKENN |
Homo sapiens |
|
| pmid |
sentence |
| 22163316 |
We demonstrate that aib1 is phosphorylated on ser728 and ser867 by cdk1/cyclin b at the onset of mitosis and remains phosphorylated until exit from m phase. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDK1 | down-regulates
phosphorylation
|
NCOA3 |
0.369 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-195233 |
Ser728 |
VVKQEQLsPKKKENN |
Homo sapiens |
|
| pmid |
sentence |
| 22163316 |
We demonstrate that aib1 is phosphorylated on ser728 and ser867 by cdk1/cyclin b at the onset of mitosis and remains phosphorylated until exit from m phase. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PFKFB4 | up-regulates activity
phosphorylation
|
NCOA3 |
0.327 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267269 |
Ser857 |
PPYNRAVsLDSPVSV |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 29615789 |
PFKFB4, a regulatory enzyme that synthesizes an allosteric stimulator of glycolysis2, was found to be a robust stimulator of SRC-3 that co-activates estrogen receptor (ER). PFKFB4 phosphorylates SRC-3 at serine 857 (S857) enhancing its transcriptional activity, whereas either suppression of PFKFB4 or ectopic expression of a phosphorylation-deficient SRC-3 mutant S857A (SRC-3S857A) significantly abolishes SRC-3-mediated transcriptional output |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CHUK | up-regulates
phosphorylation
|
NCOA3 |
0.396 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-196953 |
Ser857 |
PPYNRAVsLDSPVSV |
Homo sapiens |
Lung Cancer Cell |
| pmid |
sentence |
| 22505454 |
Herein, we report the successful identification of six functional in vivo src-3 phosphorylation sites. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-127064 |
Ser857 |
PPYNRAVsLDSPVSV |
Homo sapiens |
|
| pmid |
sentence |
| 15383283 |
Herein, we report the successful identification of six functional in vivo src-3 phosphorylation sites. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-135050 |
|
|
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 15808510 |
Ikkalpha phosphorylates eralpha, aib1/src-3, and histone h3. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
PRKACA | up-regulates
phosphorylation
|
NCOA3 |
0.361 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-129349 |
Ser857 |
PPYNRAVsLDSPVSV |
Homo sapiens |
|
| pmid |
sentence |
| 15383283 |
Herein, we report the successful identification of six functional in vivo src-3 phosphorylation sites. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-196961 |
Ser857 |
PPYNRAVsLDSPVSV |
Homo sapiens |
|
| pmid |
sentence |
| 22505454 |
Herein, we report the successful identification of six functional in vivo src-3 phosphorylation sites. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
MAPK6 | up-regulates
phosphorylation
|
NCOA3 |
0.479 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-196957 |
Ser857 |
PPYNRAVsLDSPVSV |
Homo sapiens |
Lung Cancer Cell |
| pmid |
sentence |
| 22505454 |
Here, we report that erk3 interacted with and phosphorylated steroid receptor coactivator 3 (src-3), an oncogenic protein overexpressed in multiple human cancers at serine 857 (s857) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ABL1 | up-regulates
phosphorylation
|
NCOA3 |
0.349 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-180571 |
Tyr1357 |
HPQAASIyQSSEMKG |
Homo sapiens |
|
| pmid |
sentence |
| 18765637 |
Tyrosine phosphorylation of the nuclear receptor coactivator aib1/src-3 is enhanced by abl kinase and is required for its activity in cancer cellstyrosine kinase directly phosphorylates aib1/src-3 at y1357 and modulates the association of aib1 with c-abl, eralpha, the transcriptional cofactor p300, |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IKBKB | up-regulates activity
phosphorylation
|
NCOA3 |
0.379 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251298 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11971985 |
We demonstrated the in vitro phosphorylation of SRC-3 by the two catalytic subunits of the IKK complex, IKKα and IKKβ. IKK kinase activity is required for synergistic activation with SRC-3 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SPOP | down-regulates quantity by destabilization
binding
|
NCOA3 |
0.481 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251529 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24239470 |
Mutations in SPOP represent the most common point mutations in primary prostate cancer,with recurrent mutations in SPOP in 6% to 15% of multiple independent cohorts. Wild-type SPOP will bind and promote the degradation of SRC-3,whereas prostate cancer–derived SPOP mutants lose this ability,leading to increased androgen signaling in certain model systems. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272827 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 25278611 |
Here, we analyzed changes in the ubiquitin landscape induced by prostate cancer-associated mutations of SPOP, an E3 ubiquitin ligase substrate-binding protein. SPOP mutants impaired ubiquitylation of a subset of proteins in a dominant-negative fashion. Of these, DEK and TRIM24 emerged as effector substrates consistently up-regulated by SPOP mutants. Up-regulation of DEK, TRIM24 and NCOA3 is a feature of prostate cancer SPOP mutations. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Prostate Cancer |
| + |
Cullin 7-RBX1-Skp1 | down-regulates quantity by destabilization
ubiquitination
|
NCOA3 |
0.26 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272837 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 25278611 |
Here, we analyzed changes in the ubiquitin landscape induced by prostate cancer-associated mutations of SPOP, an E3 ubiquitin ligase substrate-binding protein. SPOP mutants impaired ubiquitylation of a subset of proteins in a dominant-negative fashion. Of these, DEK and TRIM24 emerged as effector substrates consistently up-regulated by SPOP mutants. Up-regulation of DEK, TRIM24 and NCOA3 is a feature of prostate cancer SPOP mutations. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SCF-FBW7 | down-regulates quantity by destabilization
ubiquitination
|
NCOA3 |
0.296 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276066 |
|
|
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 17574025 |
We identified SCFFbw7α as an E3 ligase that binds to SRC-3 in an S505 phosphorylation-dependent manner (Figure 4Ci) and that is responsible for the further ubiquitination of SRC-3 (Figure 4A). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NCOA3 | up-regulates quantity by expression 
transcriptional regulation
|
CCND1 |
0.477 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-135056 |
|
|
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 15808510 |
Ikkalpha in conjunction with eralpha and aib1/src-3, is important in activating the transcription of estrogen-responsive genes, including cyclin d1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NCOA3 | up-regulates activity
binding
|
ATF4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275452 |
|
|
Homo sapiens |
Hepatoma Cell Line |
| pmid |
sentence |
| 31066068 |
Mechanistically, Dyrk3 directly phosphorylated NCOA3 at Ser-1330, disrupting its binding to ATF4 and thereby causing the inhibition of ATF4 transcriptional activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
NCOA3
- 
- 