Summary

Name NCOA3
Full Name Nuclear receptor coactivator 3
Synonyms NCoA-3, ACTR, Amplified in breast cancer 1 protein, AIB-1, CBP-interacting protein, pCIP, Class E basic helix-loop-helix protein 42, bHLHe42, Receptor-associated coactivator 3, RAC-3, Steroid receptor coactivator protein 3, SRC-3, Thyroid hormone receptor activator molecule 1, TRAM-1 | AIB1, BHLHE42, RAC3, TRAM1
Primary ID Q9Y6Q9
Links - -
Type protein
Relations 24
Pathways Prostate Cancer
Function Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit.

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png phosphorylation NCOA3 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation NCOA3 0.524
Publications: 4 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation NCOA3 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NCOA3 0.285
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation NCOA3 0.314
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation NCOA3 0.369
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation NCOA3 0.327
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NCOA3 0.396
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NCOA3 0.361
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NCOA3 0.479
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NCOA3 0.349
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation NCOA3 0.379
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png binding NCOA3 0.481
Publications: 2 Organism: Homo Sapiens
Pathways:Prostate Cancer
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination NCOA3 0.26
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination NCOA3 0.296
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CCND1 0.477
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding ATF4 0.2
Publications: 1 Organism: Homo Sapiens