| + |
SMAD1/5/8/SMAD4 | up-regulates activity 
binding
|
RUNX2 |
0.579 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255834 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 15573378 |
The Runx2 WT and deletion constructs (1 –495, 1–464, and 1–432) all physically interact with the BMP2 responsive Smad 1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMAD1/5/8/SMAD4 | up-regulates 
transcriptional regulation
|
DLX5 |
0.321 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255837 |
|
|
Mus musculus |
C2C12 Cell |
| pmid |
sentence |
| 12815054 |
Over-expression of Smad1 or Smad5, mediators of BMP-signaling, also induced Dlx5 expression even in the absence of BMP-2 treatment concomitant with positive ALP staining |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
SMAD4 | form complex 
binding
|
SMAD1/5/8/SMAD4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255833 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9436979 |
Bone morphogenetic protein (BMP) receptors signal by phosphorylating Smad1, which then associates with Smad4; this complex moves into the nucleus and activates transcription. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255832 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20957627 |
Whereas alk5 signalling is mediated by phosphorylation of smad2 and smad3 proteins, alk1 signalling is mediated by smad1, smad5, and smad8. Activated smads form a complex with the common smad (co-smad; smad4 in mammals) and shuttle into the nucleus. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
SMAD1/5/8/SMAD4 | up-regulates
transcriptional regulation
|
RUNX2 |
0.579 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255836 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27563484 |
Smad1/5/8-Smad4 complex transcribed Runx2 expression, as they complex with Runx2 to initiate other osteoblast gene expression. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255835 |
|
|
Mus musculus |
C2C12 Cell |
| pmid |
sentence |
| 11073979 |
As shown in Fig. 8A, overexpression of Smad5 by itself induced Runx2 expression even in the absence of BMP-2 (lane 5). Western blot analysis also confirmed the induced level of Runx2 protein in C2C12-Sm5 cells (Fig. 8B) |
|
| Publications: |
2 |
Organism: |
Homo Sapiens, Mus Musculus |
| + |
SMAD1/5/8/SMAD4 | down-regulates 
|
FBXO30 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256488 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 24076600 |
BMP-Smad1/5/8 signaling negatively regulates a gene (Fbxo30) that encodes a ubiquitin ligase required for muscle loss, which we named muscle ubiquitin ligase of the SCF complex in atrophy-1 (MUSA1) |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Muscle |
| + |
SMAD1/5/8/SMAD4 | up-regulates activity
|
mTORC1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256487 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 24145169 |
The BMP pathway is a positive regulator of muscle mass. Increasing the expression of BMP7 or the activity of BMP receptors in muscles induced hypertrophy that was dependent on Smad1/5-mediated activation of mTOR signaling |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Muscle |
| + |
SMAD1/5/8 | form complex
binding
|
SMAD1/5/8/SMAD4 |
0.67 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255838 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20957627 |
Whereas alk5 signalling is mediated by phosphorylation of smad2 and smad3 proteins, alk1 signalling is mediated by smad1, smad5, and smad8. Activated smads form a complex with the common smad (co-smad; smad4 in mammals) and shuttle into the nucleus. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
SMAD1/5/8/SMAD4