| + |
UBE2I | up-regulates 
sumoylation
|
SMAD4 |
0.609 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-98993 |
Lys113 |
KNELKHVkYCQYAFD |
Homo sapiens |
|
| pmid |
sentence |
| 12621041 |
The mh1 domain of smad4 was shown to associate physically with ubc9, the ubiquitin carrier protein (e2) conjugating enzyme in sumoylation. In cultured cells, smad4 is modified by sumo-1 at the endogenous level. The sumoylation sites were identified as two evolutionarily conserved lysine residues, lys-113 and lys-159, in the mh1 domain. We found that the mutations at lys-113 and lys-159 did not alter the ability of smad4 to form a complex with smad2 and fast on the mix.2 promoter. Importantly, sumo-1 overexpression enhanced tgf-beta-induced transcriptional responses. These findings identify sumoylation as a unique mechanism to modulate smad4-dependent cellular responses |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-98997 |
Lys159 |
APSSMMVkDEYVHDF |
Homo sapiens |
|
| pmid |
sentence |
| 12621041 |
The mh1 domain of smad4 was shown to associate physically with ubc9, the ubiquitin carrier protein (e2) conjugating enzyme in sumoylation. In cultured cells, smad4 is modified by sumo-1 at the endogenous level. The sumoylation sites were identified as two evolutionarily conserved lysine residues, lys-113 and lys-159, in the mh1 domain. We found that the mutations at lys-113 and lys-159 did not alter the ability of smad4 to form a complex with smad2 and fast on the mix.2 promoter. Importantly, sumo-1 overexpression enhanced tgf-beta-induced transcriptional responses. These findings identify sumoylation as a unique mechanism to modulate smad4-dependent cellular responses |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
USP9X | up-regulates
deubiquitination
|
SMAD4 |
0.633 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-195697 |
Lys519 |
DYPRQSIkETPCWIE |
Homo sapiens |
|
| pmid |
sentence |
| 22298955 |
Smad4 is monoubiquitinated in lysine 519 in vivo, a modification that inhibits smad4 by impeding association with phospho-smad2. Fam reverts this negative modification, re-empowering smad4 function;control of smad4 is a good way to regulate bone formation. Fam and ectodermin/tif1gamma (ecto) were reported to respectively regulate the de-ubiquitination and ubiquitination of smad4. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-183285 |
Lys519 |
DYPRQSIkETPCWIE |
Homo sapiens |
|
| pmid |
sentence |
| 19135894 |
Smad4 is monoubiquitinated in lysine 519 in vivo, a modification that inhibits smad4 by impeding association with phospho-smad2. Fam reverts this negative modification, re-empowering smad4 function;control of smad4 is a good way to regulate bone formation. Fam and ectodermin/tif1gamma (ecto) were reported to respectively regulate the de-ubiquitination and ubiquitination of smad4. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236855 |
Lys519 |
DYPRQSIkETPCWIE |
Mus musculus |
C2C12 Cell |
| pmid |
sentence |
| 20016939 |
Smad4 is monoubiquitinated in lysine 519 in vivo, a modification that inhibits smad4 by impeding association with phospho-smad2. Fam reverts this negative modification, re-empowering smad4 function;control of smad4 is a good way to regulate bone formation. Fam and ectodermin/tif1gamma (ecto) were reported to respectively regulate the de-ubiquitination and ubiquitination of smad4. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens, Mus Musculus |
| + |
PLK1 | down-regulates quantity by destabilization 
phosphorylation
|
SMAD4 |
0.257 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277591 |
Thr197 |
ASTETYStPALLAPS |
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 35437307 |
We observed that PLK1 could significantly promote the ubiquitination and degradation of Smad4 wild type, Smad4 S171A, Smad4 S187A, Smad4 S191A, respectively, but PLK1-induced the ubiquitination and degradation of Smad4 T197A were obviously inhibited (Fig. 1M). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GSK3B | down-regulates quantity by destabilization
phosphorylation
|
SMAD4 |
0.408 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276442 |
Thr265 |
ATYHHNStTTWTGSR |
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 25373906 |
In the presence of FGF, Wnt potentiates TGF-β signaling by preventing Smad4 GSK3 phosphorylations that inhibit a transcriptional activation domain located in the linker region. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276441 |
Thr269 |
HNSTTTWtGSRTAPY |
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 25373906 |
In the presence of FGF, Wnt potentiates TGF-β signaling by preventing Smad4 GSK3 phosphorylations that inhibit a transcriptional activation domain located in the linker region. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276440 |
Thr273 |
TTWTGSRtAPYTPNL |
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 25373906 |
In the presence of FGF, Wnt potentiates TGF-β signaling by preventing Smad4 GSK3 phosphorylations that inhibit a transcriptional activation domain located in the linker region. |
|
| Publications: |
3 |
Organism: |
Mus Musculus |
| + |
MAPK1 | up-regulates
phosphorylation
|
SMAD4 |
0.526 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-101660 |
Thr277 |
GSRTAPYtPNLPHHQ |
Homo sapiens |
|
| pmid |
sentence |
| 12801888 |
Phosphorylation of thr276 is shown to be important for tgf-?-Induced nuclear accumulation and, as a consequence, transcriptional activity of smad4. these results suggest that smad4 can be phosphorylated by erk2 at thr276. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ERK1/2 | up-regulates
phosphorylation
|
SMAD4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-244739 |
Thr277 |
GSRTAPYtPNLPHHQ |
Homo sapiens |
|
| pmid |
sentence |
| 12801888 |
Our results suggest that map kinase can phosphorylate thr276 of smad4 and that phosphorylation can lead to enhanced tgf-beta-induced nuclear accumulation and, as a consequence, enhanced transcriptional activity of smad4. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Colorectal Carcinoma, Hepatocellular Tumor, Pancreatic ductal adenocarcinoma (PDA) |
| + |
MAPK3 | up-regulates
phosphorylation
|
SMAD4 |
0.431 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-101664 |
Thr277 |
GSRTAPYtPNLPHHQ |
Homo sapiens |
|
| pmid |
sentence |
| 12801888 |
Our results suggest that map kinase can phosphorylate thr276 of smad4 and that phosphorylation can lead to enhanced tgf-beta-induced nuclear accumulation and, as a consequence, enhanced transcriptional activity of smad4. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMAD4 | down-regulates quantity by repression
transcriptional regulation
|
MYC |
0.627 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251493 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11689553 |
Down-regulation of c-Myc is a critical event for growth inhibition induced by transforming growth factor-β (TGF-β) and is frequently impaired in cancer cells. We determined a Smad-responsive element in the c-mycpromoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Colorectal Carcinoma, Hepatocellular Tumor |
| + |
SMURF1 | down-regulates activity
ubiquitination
|
SMAD4 |
0.735 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236096 |
|
|
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 15817471 |
Smurfs, which otherwise cannot directly bind to smad4, mediated poly-ubiquitination of smad4 in the presence of smad6 or smad7. Smad signaling is negatively regulated by inhibitory (i) smads and ubiquitin-mediated processes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FBXW11 | up-regulates
ubiquitination
|
SMAD4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-123060 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14988407 |
We have identified scf(beta-trcp1), a ubiquitin (e3) ligase, as a critical determinant for the protein degradation of smad4 protein. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AMOT/MPP5/INADL/LIN7C | up-regulates
binding
|
SMAD4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-210096 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9748228 |
Bmp7 stimulated phosphorylation of endogenous smad1 and 5, formation of complexes with smad4 and induced the promoter for the homeobox gene, tlx2 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PIAS4 | down-regulates
binding
|
SMAD4 |
0.539 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-104541 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12904571 |
Piasy binds most strongly with smad3 and also associates with other receptor-regulated smads and smad4. smad3, smad4, and piasy can form a ternary complex. Piasy does not inhibit smad complex binding to dna, but it represses smad transcriptional activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMAD4 | form complex 
binding
|
SMAD4/JUN |
0.663 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-50589 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9312063 |
Our analysis of the regulation of dpc4 transcriptional activity by c-jun was consistent with the possibility that c-jun and dpc4 could interact and produce trans-activation of the 3tp-lux reporter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMAD1 | up-regulates
binding, phosphorylation
|
SMAD4 |
0.655 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-172990 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21454478 |
Upon ligand binding, the specific heteromeric transmembrane serine/threonine kinase receptor complexes undergo phosphorylation/activation and subsequently phosphorylate the two ser residues in the c-terminal sxs motif of specific r-smads, smad1/5/8 for bmp pathway and smad2/3 for tgf-_/activin signaling. The activated r-smads then associate with co-smad, smad4. The heteromeric complexes translocate into the nucleus, where they bind to dna directly or indirectly to regulate the transcription of specific genes. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-168734 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20957627 |
Whereas alk5 signalling is mediated by phosphorylation of smad2 and smad3 proteins, alk1 signalling is mediated by smad1, smad5, and smad8. Activated smads form a complex with the common(co-Smad; Smad4 in mammals) and shuttle into the nucleus. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
SMAD5 | up-regulates
phosphorylation
|
SMAD4 |
0.659 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-168737 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20957627 |
Whereas alk5 signalling is mediated by phosphorylation of smad2 and smad3 proteins, alk1 signalling is mediated by smad1, smad5, and smad8. Activated smads form a complex with the common smad (co-smad; smad4 in mammals) and shuttle into the nucleus. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMAD1/5/8 | up-regulates
binding
|
SMAD4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269952 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21454478 |
Upon ligand binding, the specific heteromeric transmembrane serine/threonine kinase receptor complexes undergo phosphorylation/activation and subsequently phosphorylate the two ser residues in the c-terminal sxs motif of specific r-smads, smad1/5/8 for bmp pathway and smad2/3 for tgf-_/activin signaling. The activated r-smads then associate with co-smad, smad4. The heteromeric complexes translocate into the nucleus, where they bind to dna directly or indirectly to regulate the transcription of specific genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Gbeta | up-regulates
phosphorylation
|
SMAD4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270107 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12801888 |
Our results suggest that map kinase can phosphorylate thr276 of smad4 and that phosphorylation can lead to enhanced tgf-beta-induced nuclear accumulation and, as a consequence, enhanced transcriptional activity of smad4. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STUB1 | down-regulates quantity by destabilization
polyubiquitination
|
SMAD4 |
0.405 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272947 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 14701756 |
We demonstrate that the coexpression of Smad1 and Smad4 with the CHIP protein results in the degradation of the Smad proteins through a ubiquitin-mediated process. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PIAS1 | up-regulates
sumoylation
|
SMAD4 |
0.403 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-123462 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15028714 |
These data demonstrate that pias1 protein positively modulates tgf-beta responses as a sumo e3 ligase for smad4 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SKP2 | down-regulates
ubiquitination
|
SMAD4 |
0.406 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-127964 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15314162 |
We found that skp2, the f-box component of scfskp2, physically interacted with smad4 at the physiological levels. Several cancer-derived unstable mutants exhibited significantly increased binding to skp2, which led to their increased ubiquitination and accelerated proteolysis. These results suggest an important role for the scfskp2 complex in switching cancer mutants of smad4 to undergo polyubiquitination-dependent degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMAD4 | form complex
binding
|
SMAD1/4 |
0.655 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-103618 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9436979 |
Bone morphogenetic protein (BMP) receptors signal by phosphorylating Smad1, which then associates with Smad4; this complex moves into the nucleus and activates transcription. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMAD4 | form complex
binding
|
SMAD1/5/8/SMAD4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255833 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9436979 |
Bone morphogenetic protein (BMP) receptors signal by phosphorylating Smad1, which then associates with Smad4; this complex moves into the nucleus and activates transcription. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255832 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20957627 |
Whereas alk5 signalling is mediated by phosphorylation of smad2 and smad3 proteins, alk1 signalling is mediated by smad1, smad5, and smad8. Activated smads form a complex with the common smad (co-smad; smad4 in mammals) and shuttle into the nucleus. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
COPS5 | down-regulates
ubiquitination
|
SMAD4 |
0.444 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-114697 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11818334 |
We report a novel mechanism of smad4 degradation. Jab1 interacts directly with smad4 and induces its ubiquitylation for degradation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
JUN | up-regulates activity
binding
|
SMAD4 |
0.663 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236139 |
|
|
Canis lupus familiaris |
|
| pmid |
sentence |
| 9312063 |
Our analysis of the regulation of dpc4 transcriptional activity by c-jun was consistent with the possibility that c-jun and dpc4 could interact and produce trans-activation of the 3tp-lux reporter. |
|
| Publications: |
1 |
Organism: |
Canis Lupus Familiaris |
| Pathways: | TGF-beta Signaling |
| + |
NUP214 | up-regulates
binding
|
SMAD4 |
0.542 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-117647 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12917407 |
We demonstrate that smad3 and smad4 are capable of interaction with the nucleoporin can/nup214, and this interaction is required for nuclear import |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
XPO1 | down-regulates
relocalization
|
SMAD4 |
0.306 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-84247 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11074002 |
We demonstrate that inhibition of crm1-mediated nuclear export by treatment of cells with leptomycin b results in endogenous smad4 accumulating very rapidly in the nucleus. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SKIL | down-regulates activity
binding
|
SMAD4 |
0.882 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-71633 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10531062 |
Thus, SnoN can interact with Smad4 and Smad2 and inhibit their abilities to activate transcription. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236152 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12793438 |
The ski and snon protein family associate with and repress the activity of smad2, smad3, and smad4, three members of the tgf-fl signaling pathway |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | TGF-beta Signaling |
| + |
SMAD4 | up-regulates activity 
|
LEF1 |
0.677 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-229311 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 10890911 |
Coexpression of smad2 and smad4, smad3 alone, or smad3 and smad4 resulted in strong enhancement of lef1-dependent transcriptional activity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Colorectal Carcinoma, Hepatocellular Tumor |
| + |
SMAD4 | form complex
binding
|
SMAD2/SMAD4 |
0.708 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235178 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11274206 |
the receptor-regulated Smad, such as Smad2, forms a heterocomplex with the co-mediator Smad, Smad4 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hepatocellular Tumor, Pancreatic ductal adenocarcinoma (PDA), TGF-beta Signaling, TGFb in cancer |
| + |
SMAD3 | up-regulates activity
binding
|
SMAD4 |
0.698 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235168 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9843571 |
TGF-² treatment initiates a kinase cascade that results in the phosphorylation of Smad3, followed by its heteromerization with Smad4 and subsequent translocation into the nucleus. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Colorectal Carcinoma, Hepatocellular Tumor, Pancreatic ductal adenocarcinoma (PDA), TGF-beta Signaling, TGFb in cancer |
| + |
SMURF | down-regulates activity
ubiquitination
|
SMAD4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253259 |
|
|
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 15817471 |
Smurfs, which otherwise cannot directly bind to smad4, mediated poly-ubiquitination of smad4 in the presence of smad6 or smad7. Smad signaling is negatively regulated by inhibitory (i) smads and ubiquitin-mediated processes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | TGF-beta Signaling |
| + |
SMAD4 | form complex
binding
|
SMAD8/SMAD4 |
0.67 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255269 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20957627 |
Whereas alk5 signalling is mediated by phosphorylation of smad2 and smad3 proteins, alk1 signalling is mediated by smad1, smad5, and smad8. Activated smads form a complex with the common smad (co-smad; smad4 in mammals) and shuttle into the nucleus. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMAD9 | up-regulates
phosphorylation
|
SMAD4 |
0.67 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-168740 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20957627 |
Whereas alk5 signalling is mediated by phosphorylation of smad2 and smad3 proteins, alk1 signalling is mediated by smad1, smad5, and smad8. Activated smads form a complex with the common smad (co-smad; smad4 in mammals) and shuttle into the nucleus. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMAD6 | down-regulates activity
binding
|
SMAD4 |
0.556 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-195648 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22298955 |
On the other hand, Smad6 competes with R-Smad and forms a non-functional complex with Smad4, which will inhibit BMP signaling in bone formation. Smad6 is involved in a negative feedback loop regulating BMP signaling and is required to limit BMP signaling during endochondral bone formation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | TGF-beta Signaling |
| + |
SMAD4 | form complex
binding
|
SMAD5/SMAD4 |
0.659 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255267 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20957627 |
Whereas alk5 signalling is mediated by phosphorylation of smad2 and smad3 proteins, alk1 signalling is mediated by smad1, smad5, and smad8. Activated smads form a complex with the common smad (co-smad; smad4 in mammals) and shuttle into the nucleus. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMAD2 | up-regulates activity
binding
|
SMAD4 |
0.708 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235183 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11274206 |
the receptor-regulated Smad, such as Smad2, forms a heterocomplex with the co-mediator Smad, Smad4 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hepatocellular Tumor, Pancreatic ductal adenocarcinoma (PDA), TGF-beta Signaling, TGFb in cancer |
| + |
SNIP1 | down-regulates
binding
|
SMAD4 |
0.573 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-78984 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10887155 |
In this study, we characterize a novel nuclear protein, termed snip1 its principal mechanism of action appears to be through transcription by binding to cbp/p300 and interfering with the ability of these coactivators to interact with smad4 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SKI | down-regulates activity
binding
|
SMAD4 |
0.813 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236074 |
|
|
Homo sapiens |
Melanoma Cell |
| pmid |
sentence |
| 12793438 |
The ski and snon protein family associate with and repress the activity of smad2, smad3, and smad4, three members of the tgf-fl signaling pathway |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | TGF-beta Signaling |
| + |
SMAD4 | form complex
binding
|
SMAD3/SMAD4 |
0.698 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-229560 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9843571 |
TGF-beta treatment initiates a kinase cascade that results in the phosphorylation of Smad3, followed by its heteromerization with Smad4 and subsequent translocation into the nucleus. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hepatocellular Tumor, Pancreatic ductal adenocarcinoma (PDA), TGF-beta Signaling, TGFb in cancer |
| + |
BTRC | down-regulates
ubiquitination
|
SMAD4 |
0.396 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-123057 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14988407 |
Here we show that beta-trcp1, a f-box protein in the scf e3 ligase complex, interacts with smad4 and induces the degradation of smad4 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
VPS39 | down-regulates activity
relocalization
|
SMAD4 |
0.324 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261377 |
|
|
Chlorocebus aethiops |
|
| pmid |
sentence |
| 12941698 |
The data demonstrating binding of TLP to TGF-β and activin type II receptors and selective inhibition of Smad3/Smad4 complex formation by deregulated TLP suggest that TLP is involved in localizing these receptors and Smad4 to specific intracellular compartments, where it regulates formation of Smad3/Smad4 but not Smad2/Smad4 complexes. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
3.0
SMAD4
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