| + |
SMAD1/4 | up-regulates quantity by expression 
transcriptional regulation
|
PPARG |
0.285 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236233 |
|
|
Homo sapiens |
C3H10T1/2 Cell |
| pmid |
sentence |
| 12589053 |
Overexpression of Smad6, a natural antagonist for Smad1, blocked PPARgamma expression and adipocytic differentiation induced by BMP2 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253551 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18854943 |
This Smad1/4 complex can directly interact with Shn-2 and C/EBP a on the PPAR g promoter thus, resulting in the transcriptional activation of PPAR g |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
SMAD1/4 | up-regulates
transcriptional regulation
|
DLX5 |
0.301 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255789 |
|
|
Mus musculus |
C2C12 Cell |
| pmid |
sentence |
| 12815054 |
Over-expression of Smad1 or Smad5, mediators of BMP-signaling, also induced Dlx5 expression even in the absence of BMP-2 treatment concomitant with positive ALP staining |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
SMAD6 | down-regulates 
binding
|
SMAD1/4 |
0.576 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217706 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12857866 |
Smad6 also inhibits bmp signaling by forming a complex with smad1 and by interfering with complex formation between smad1 and smad4 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMAD1/4 | up-regulates activity 
binding
|
RUNX2 |
0.564 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255782 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15573378 |
The Runx2 WT and deletion constructs (1 –495, 1–464, and 1–432) all physically interact with the BMP2 responsive Smad 1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BMPR1A | up-regulates activity
phosphorylation
|
SMAD1/4 |
0.71 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255778 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8893010 |
Conversely, Smad1 and DPC4 formed a complex when the cells were stimulated with BMP4 but not with activin of TGF-beta. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMAD4 | form complex 
binding
|
SMAD1/4 |
0.674 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-103618 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9436979 |
Bone morphogenetic protein (BMP) receptors signal by phosphorylating Smad1, which then associates with Smad4; this complex moves into the nucleus and activates transcription. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SKIL | down-regulates
binding
|
SMAD1/4 |
0.685 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217709 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22298955 |
Ski also represses bmp signaling through interactions with smad4 and bmp-specific r-smads, smad1 or smad7 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217703 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12419246 |
Ski also represses bmp signaling through interactions with smad4 and bmp-specific r-smads, smad1 or smad7 |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
SMAD1/4 | up-regulates activity
binding
|
CEBPB |
0.561 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253552 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18854943 |
This Smad1/4 complex can directly interact with Shn-2 and C/EBP a on the PPAR g promoter thus, resulting in the transcriptional activation of PPAR g |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMAD1 | form complex
binding
|
SMAD1/4 |
0.674 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255774 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8893010 |
Conversely, Smad1 and DPC4 formed a complex when the cells were stimulated with BMP4 but not with activin of TGF-beta. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-103615 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9436979 |
Bone morphogenetic protein (BMP) receptors signal by phosphorylating Smad1, which then associates with Smad4; this complex moves into the nucleus and activates transcription. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
SMAD1/4 | up-regulates quantity by expression
transcriptional regulation
|
BMP7 |
0.559 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248843 |
|
|
Drosophila melanogaster |
|
| pmid |
sentence |
| 19896409 |
BMPs first bind to and activate their transmembrane serine/threonine kinase receptors, which in turn phosphorylate the transcription factors Smad1/5/8 at its two C-terminal serines (SVS). Phosphorylated Smad1Cter binds to Smad4 (co-Smad) and translocates and accumulates in the nucleus, activating BMP-responsive genes (Fig. 2) [21] and [22], such as BMP4/7 and others. |
|
| Publications: |
1 |
Organism: |
Drosophila Melanogaster |
| + |
BMPR1A | up-regulates activity
|
SMAD1/4 |
0.71 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255787 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 19620713 |
The expression of CA-BMPr1A and CA-BMPr1B mRNA was confirmed by RT-PCR using appropriate primers to distinguish expression of the constitutively active receptors from endogenous BMP receptors; specific antibodies for these receptors were not available. However, the functional effects of their expression, i.e., phosphorylation of Smad1/5/8 and p38 MAPK, verify overexpression of the constitutively active receptors (Fig. 3B). Thus, their overexpression provoked a substantial rise in the phosphorylation of Smad1/5/8 and p38 MAPK, known downstream phosphorylated intermediates in the BMP signaling pathway (Fig. 3B) (16, 17). |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
SMAD1/4 | up-regulates quantity by expression
transcriptional regulation
|
BMP4 |
0.579 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248842 |
|
|
Drosophila melanogaster |
|
| pmid |
sentence |
| 19896409 |
BMPs first bind to and activate their transmembrane serine/threonine kinase receptors, which in turn phosphorylate the transcription factors Smad1/5/8 at its two C-terminal serines (SVS). Phosphorylated Smad1Cter binds to Smad4 (co-Smad) and translocates and accumulates in the nucleus, activating BMP-responsive genes (Fig. 2) [21] and [22], such as BMP4/7 and others. |
|
| Publications: |
1 |
Organism: |
Drosophila Melanogaster |
4.0
SMAD1/4
CPX-54