| + |
UBE2O | down-regulates 
ubiquitination
|
SMAD6 |
0.455 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-192255 |
Lys173 |
LLLEQELkTVTYSLL |
Homo sapiens |
|
| pmid |
sentence |
| 23455153 |
We showed that ube2o functions as an e2-e3 hybrid to monoubiquitinate smad6 at lysine 174 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMAD6 | down-regulates
binding
|
SMAD1/4 |
0.592 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217706 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12857866 |
Smad6 also inhibits bmp signaling by forming a complex with smad1 and by interfering with complex formation between smad1 and smad4 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMURF | down-regulates activity
relocalization
|
SMAD6 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253261 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22298955 |
Smurf1, with its WW domain, specifically binds to the PY motif of Smad6 and transports Smad6 into the cytoplasm. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | TGF-beta Signaling |
| + |
SMAD1 | up-regulates quantity 
transcriptional regulation
|
SMAD6 |
0.594 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268935 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 22219353 |
Chromatin immunoprecipitation (ChIP) revealed a subset of the BIG (BMP4 induced genes) signature, including Satb2, Smad6, Hand1, Gadd45γ and Gata3, that was bound by Smad1/5 in the developing mandible, revealing direct Smad-mediated regulation |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
SMAD6 | up-regulates activity
binding
|
SMURF1 |
0.836 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272786 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 19561075 |
Smad6 mediates Tbx6 ubiquitination and proteasomal degradation. Tbx6 forms a ternary complex with Smad6 and Smurf1. Here, we report that Tbx6 interacts directly with Smad6, an inhibitory Smad that antagonizes the BMP signal. This interaction is mediated through the Mad homology 2 (MH2) domain of Smad6 and residues 90-180 of Tbx6. We demonstrate that Smad6 facilitates the degradation of Tbx6 protein through recruitment of Smurf1, a ubiquitin E3 ligase. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMAD6 | down-regulates 
|
BMPR1A |
0.748 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236861 |
|
|
Mus musculus |
C2C12 Cell |
| pmid |
sentence |
| 10564272 |
We found that both smad6 and smad7 inhibit the activation of smad1 and smad5 by bmpr-ia/alk-3 and bmpr-ib/alk-6, as well as that by alk-2 |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
SMAD6 | down-regulates
binding
|
SMAD1 |
0.594 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-103621 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12857866 |
Smad6 also inhibits bmp signaling by forming a complex with smad1 and by interfering with complex formation between smad1 and smad4 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMAD6 | down-regulates activity
binding
|
TGFBR1 |
0.751 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-64079 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9892110 |
SMAD6 functions as a negative regulator of the TGFB and BMP signaling pathways by interacting with other SMADs and/or TBRI. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-167160 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20663871 |
The inhibitory Smads (I-Smads), i.e. Smad6 and Smad7, are negative regulators of transforming growth factor-_ (TGF-_) family signaling. I-Smads inhibit TGF-_ family signaling principally through physical interaction with type I receptors (activin receptor-like kinases), so as to compete with receptor-regulated Smads (R-Smads) for activation. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | TGF-beta Signaling |
| + |
SMAD6 | down-regulates activity
binding
|
MAP3K7 |
0.585 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235571 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 11737269 |
Smad6 interacts with tak1 and tab1, and smad7 with tab1. The interaction of i-smads with tak1 and/or tab1 implies that several mechanisms exist underlying the repression of the tak1-p38 kinase pathway by i-smads. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| Pathways: | TGF-beta Signaling |
| + |
SMAD6 | down-regulates quantity by destabilization
binding
|
TBX6 |
0.321 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272785 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 19561075 |
Smad6 mediates Tbx6 ubiquitination and proteasomal degradation. Tbx6 forms a ternary complex with Smad6 and Smurf1. Here, we report that Tbx6 interacts directly with Smad6, an inhibitory Smad that antagonizes the BMP signal. This interaction is mediated through the Mad homology 2 (MH2) domain of Smad6 and residues 90-180 of Tbx6. We demonstrate that Smad6 facilitates the degradation of Tbx6 protein through recruitment of Smurf1, a ubiquitin E3 ligase. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMAD6 | down-regulates
binding
|
TAB1 |
0.584 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-112642 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11737269 |
Smad6 interacts with tak1 and tab1, and smad7 with tab1. The interaction of i-smads with tak1 and/or tab1 implies that several mechanisms exist underlying the repression of the tak1-p38 kinase pathway by i-smads. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMAD6 | down-regulates activity
binding
|
SMAD4 |
0.59 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-195648 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22298955 |
On the other hand, Smad6 competes with R-Smad and forms a non-functional complex with Smad4, which will inhibit BMP signaling in bone formation. Smad6 is involved in a negative feedback loop regulating BMP signaling and is required to limit BMP signaling during endochondral bone formation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | TGF-beta Signaling |
| + |
PRKX | up-regulates activity
phosphorylation
|
SMAD6 |
0.423 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279270 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16491121 |
In vitro phosphorylation assays demonstrated that PrKX phosphorylates Smad6 at a serine residue. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMURF1 | down-regulates activity
relocalization
|
SMAD6 |
0.836 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-105931 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22298955 |
Smurf1, with its WW domain, specifically binds to the PY motif of Smad6 and transports Smad6 into the cytoplasm. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMAD6 | down-regulates activity
binding
|
SMAD3 |
0.513 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-64071 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9892110 |
Smad6 and smad7, can prevent tgfb signaling by interacting either with the receptor or with smad2 and smad3 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | TGF-beta Signaling |
| + |
SMAD6 | up-regulates activity
binding
|
HOXC8 |
0.518 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-75823 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10722652 |
Smad6 interacts with hox transcription factors as part of the negative feedback circuit in the bmp signaling pathway |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMAD6 | up-regulates
binding
|
PELI1 |
0.326 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-185128 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19352540 |
Mad6-pellino-1 interaction abrogated signaling mediated by a complex of irak1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMAD5 | up-regulates quantity
transcriptional regulation
|
SMAD6 |
0.614 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268940 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 22219353 |
Chromatin immunoprecipitation (ChIP) revealed a subset of the BIG (BMP4 induced genes) signature, including Satb2, Smad6, Hand1, Gadd45γ and Gata3, that was bound by Smad1/5 in the developing mandible, revealing direct Smad-mediated regulation |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
SMAD6 | down-regulates
binding
|
NR2C2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-112636 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11737269 |
Smad6 interacts with tak1 and tab1, and smad7 with tab1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
SMAD6
- 
- 