Relation Results

Identifier	Residue	Organism
SIGNOR-260983		Homo sapiens
pmid	sentence
23279204	G3BP1 and G3BP2 form homo‐ and hetero‐multimers to induce SGs

Identifier	Residue	Organism	Cell Line
SIGNOR-260864		Homo sapiens	HEK-293 Cell
pmid	sentence
23279204	Ras-GTPase-activating protein SH3 domain-binding protein 1 (G3BP1) is a component of SGs that initiates the assembly of SGs by forming a multimer. In this study, we examined the role of G3BP2, a close relative of G3BP1, in SG formation. Although single knockdown of either G3BP1 or G3BP2 in 293T cells partially reduced the number of SG-positive cells induced by arsenite, the knockdowns of both genes significantly reduced the number. G3BP2 formed a homo-multimer and a hetero-multimer with G3BP1. Moreover, like G3BP1, the overexpression of G3BP2 induced SGs even without stress stimuli.

Publications:

2

Organism:

Homo Sapiens

Pathways:

COVID-19 Causal Network, Innate Immune Response, SARS-CoV STRESS GRANULES

Identifier	Residue	Organism	Cell Line
SIGNOR-260984		Homo sapiens	HEK-293T Cell
pmid	sentence
23279204	G3BP1 and G3BP2 form homo‐ and hetero‐multimers to induce SGs

Identifier	Residue	Organism
SIGNOR-260747		Homo sapiens
pmid	sentence
25520508	Ras-GTPase-activating protein (SH3 domain) binding protein 1 (G3BP1) is a stress granule-resident protein that nucleates stress granule assembly and is also inactivated or coopted by many viruses to promote productive infection

Publications:

2

Organism:

Homo Sapiens

Pathways:

COVID-19 Causal Network, Innate Immune Response, SARS-CoV STRESS GRANULES

Identifier	Residue	Organism
SIGNOR-261227		Homo sapiens
pmid	sentence
25683715	DHX30, DDX28, FASTKD2, and FASTKD5 Are Bona Fide RNA Granule Proteins. FASTKD5 siRNA treatment caused a reduction of all RNA granule proteins, along with MRPS18B, a protein of the mt-SSU.

Publications:

1

Organism:

Homo Sapiens

Identifier	Residue	Organism
SIGNOR-261229		Homo sapiens
pmid	sentence
25683715	DHX30, DDX28, FASTKD2, and FASTKD5 Are Bona Fide RNA Granule Proteins. FASTKD5 siRNA treatment caused a reduction of all RNA granule proteins, along with MRPS18B, a protein of the mt-SSU.

Publications:

1

Organism:

Homo Sapiens

Pathways:

Innate Immune Response

Identifier	Residue	Organism	Cell Line
SIGNOR-262266		Mus musculus	Neuro-2a Cell
pmid	sentence
26521126	We report that UBQLN2 up-regulation cause a cellular stress which leads to MAPK activation. Interestingly, kinases have been recently shown to have a critical role in TDP-43 accumulation in stress granules following a chronic stress

Publications:

1

Organism:

Mus Musculus

Identifier	Residue	Organism
SIGNOR-260939		Homo sapiens
pmid	sentence
20573744	Here we show that LARP4B is a cytoplasmic protein that co-sediments with polysomes and accumulates upon stress induction in stress granules.

Publications:

1

Organism:

Homo Sapiens

Pathways:

COVID-19 Causal Network, SARS-CoV STRESS GRANULES

Identifier	Residue	Organism
SIGNOR-260866		Homo sapiens
pmid	sentence
27920254	Stress granules (SGs) are large macromolecular aggregates that contain translation initiation complexes and mRNAs. Stress granule formation coincides with translational repression, and stress granules actively signal to mediate cell fate decisions by signaling to the translation apparatus to (i) maintain translational repression, (ii) mount various transcriptional responses, including innate immunity, and (iii) repress apoptosis.

Publications:

1

Organism:

Homo Sapiens

Pathways:

COVID-19 Causal Network, SARS-CoV STRESS GRANULES

Identifier	Residue	Organism
SIGNOR-260865		Homo sapiens
pmid	sentence
27920254	Stress granules (SGs) are large macromolecular aggregates that contain translation initiation complexes and mRNAs. Stress granule formation coincides with translational repression, and stress granules actively signal to mediate cell fate decisions by signaling to the translation apparatus to (i) maintain translational repression, (ii) mount various transcriptional responses, including innate immunity, and (iii) repress apoptosis.

Publications:

1

Organism:

Homo Sapiens

Pathways:

COVID-19 Causal Network, SARS-CoV STRESS GRANULES

Identifier	Residue	Organism
SIGNOR-260867		Homo sapiens
pmid	sentence
27920254	Stress granules (SGs) are large macromolecular aggregates that contain translation initiation complexes and mRNAs. Stress granule formation coincides with translational repression, and stress granules actively signal to mediate cell fate decisions by signaling to the translation apparatus to (i) maintain translational repression, (ii) mount various transcriptional responses, including innate immunity, and (iii) repress apoptosis.

Publications:

1

Organism:

Homo Sapiens

Pathways:

COVID-19 Causal Network, Innate Immune Response, SARS-CoV STRESS GRANULES

Identifier	Residue	Organism
SIGNOR-261226		Homo sapiens
pmid	sentence
25683715	DHX30, DDX28, FASTKD2, and FASTKD5 Are Bona Fide RNA Granule Proteins. FASTKD5 siRNA treatment caused a reduction of all RNA granule proteins, along with MRPS18B, a protein of the mt-SSU.

Publications:

1

Organism:

Homo Sapiens

Identifier	Residue	Organism
SIGNOR-261228		Homo sapiens
pmid	sentence
25683715	DHX30, DDX28, FASTKD2, and FASTKD5 Are Bona Fide RNA Granule Proteins. FASTKD5 siRNA treatment caused a reduction of all RNA granule proteins, along with MRPS18B, a protein of the mt-SSU.

Publications:

1

Organism:

Homo Sapiens

Pathways:

Innate Immune Response

Name	Stress_granules
Primary ID	SIGNOR-PH124
Type	phenotype
Description	Stress granules (SGs) are large macromolecular aggregates that contain translation initiation complexes and mRNAs. Stress granule formation coincides with translational repression, and stress granules actively signal to mediate cell fate decisions by signaling to the translation apparatus to (i) maintain translational repression, (ii) mount various transcriptional responses, including innate immunity, and (iii) repress apoptosis.PMID:27920254
Relations	13
Pathways	COVID-19 Causal Network, Innate Immune Response, SARS-CoV STRESS GRANULES

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