| + |
60S cytosolic large ribosomal subunit | up-regulates 
|
Protein_synthesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262413 |
|
|
|
|
| pmid |
sentence |
| 25901680 |
Ribosomes are translational machineries that catalyse protein synthesis. |
|
| Publications: |
1 |
| Pathways: | Initiation of Translation |
| + |
EIF4E2/GIGYF2 complex | down-regulates 
|
Protein_synthesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261013 |
|
|
Homo sapiens |
HeLa-S3 Cell |
| pmid |
sentence |
| 22751931 |
A Novel 4EHP-GIGYF2 Translational Repressor Complex Is Essential for Mammalian Development|m4EHP and/or GIGYF2 proteins repress translation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GSK3B | down-regulates
|
Protein_synthesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255110 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15829723 |
GSK-3beta is a serine/threonine kinase that can block translation that is initiated by eukaryotic initiation factor-2B (24) and may thereby reduce protein synthesis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Skeletal Muscle |
| Pathways: | Insulin Signaling, MTOR Signaling, PI3K/AKT Signaling |
| + |
EIF4E2/GIGYF1 complex | down-regulates
|
Protein_synthesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261012 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30917308 |
4EHP forms complexes with the GYF domain-containing proteins GIGYF1 and GIGYF2, which are critical for this translational repression |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
80S_cytosolic_ribosome | up-regulates 
|
Protein_synthesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269173 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 35489072 |
In eukaryotes, mRNA is recruited to the 43S pre-initiation complex (43S PIC), which consists of the 40S ribosomal subunit, translation initiation factors eIF1, eIF1A, eIF3, eIF5, and a ternary complex (TC) composed of eIF2, GTP and Met-tRNAiMet. 43S PIC binds to the 5′ end of the mRNA and scans along the 5′ untranslated region (5′UTR) in the 3′ direction to find the start codon (AUG) within the context of an optimal Kozak sequence. Start codon recognition stabilizes the 48S initiation complex (48S IC), initiates dissociation of eIF1, eIF1A, eIF2 and eIF5, and promotes recruitment of the 60S ribosomal subunit to form 80S IC ready to enter the elongation cycle of protein synthesis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Initiation of Translation |
| + |
EIF4E | up-regulates
|
Protein_synthesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236806 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15094766 |
A key player in the regulation of translation is the mRNA 5' cap-binding protein eIF4E, which is the rate-limiting member of the eIF4F complex |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, Insulin Signaling, MTOR Signaling, PI3K/AKT Signaling, SARS-CoV STRESS GRANULES |
| + |
EIF2S1 | up-regulates
|
Protein_synthesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260625 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11381086 |
Translation initiation is inhibited in cells exposed to different stressful conditions. The phosphorylation of the α subunit of eukaryotic translation initiation factor 2 (eIF2α) plays an important role in this stereotyped response, and is mediated by distinct kinases that are activated by specific stress signals. When phosphorylated on serine 51, eIF2α binds to and inhibits the guanine nucleotide exchange factor, eIF2B. The latter is required for the formation of the eukaryotic translational preinitiation complexes, and its sequestration in an inactive complex with phosphorylated eIF2α inhibits the initiation step of protein synthesis. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260166 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31226023 |
Activated PERK phosphorylates the α subunit of eukaryotic initiation factor 2 (eIF2α), which inhibits the conversion of inactive GDP-bound eIF2α back to the active GTP-bound form, thereby suppressing translation initiation.The resulting global attenuation of protein synthesis reduces the ER protein influx and allows the ER to reprogram for preferential expression of UPR genes. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, Initiation of Translation, SARS-CoV STRESS GRANULES, SARS-CoV ER STRESS |
| + |
LARP4B | up-regulates
|
Protein_synthesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260942 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20573744 |
Our data suggest LARP4B to act as a general stimulatory factor of translation, associated in poly(A)-mRNA-bound mRNP complexes. Under physiological conditions, LARP4B co-sedimented with polysomes in cellular extracts, suggesting a role in translation. In agreement with this notion, overexpression of LARP4B stimulated protein synthesis, whereas knockdown of the factor by RNA interference impaired translation of a large number of cellular mRNAs. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, SARS-CoV STRESS GRANULES |
| + |
39S mitochondrial large ribosomal subunit | up-regulates
|
Protein_synthesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262333 |
|
|
|
|
| pmid |
sentence |
| 25838379 |
The highly divergent ribosomes of human mitochondria (mitoribosomes) synthesize 13 essential proteins of oxidative phosphorylation complexes. |
|
| Publications: |
1 |
| + |
40S cytosolic small ribosomal subunit | up-regulates
|
Protein_synthesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262412 |
|
|
|
|
| pmid |
sentence |
| 25901680 |
Ribosomes are translational machineries that catalyse protein synthesis. |
|
| Publications: |
1 |
| Pathways: | Initiation of Translation, SARS-CoV STRESS GRANULES, SARS-CoV ER STRESS |
| + |
Stress_granules | down-regulates
|
Protein_synthesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260866 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27920254 |
Stress granules (SGs) are large macromolecular aggregates that contain translation initiation complexes and mRNAs. Stress granule formation coincides with translational repression, and stress granules actively signal to mediate cell fate decisions by signaling to the translation apparatus to (i) maintain translational repression, (ii) mount various transcriptional responses, including innate immunity, and (iii) repress apoptosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, SARS-CoV STRESS GRANULES |
| + |
28S mitochondrial small ribosomal subunit | up-regulates
|
Protein_synthesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261487 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27023846 |
Mitochondrial ribosomes (mitoribosomes) perform protein synthesis inside mitochondria, the organelles responsible for energy conversion and adenosine triphosphate production in eukaryotic cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FUS | down-regulates
|
Protein_synthesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262820 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 33082139 |
When mTORC2 is inhibited, FUS is recruited to polyribosomes to promote translation inhibition and polyribosome stalling. Panel iv, ALS-FUS R521G and P525L mutants that localize more prominently to the cytoplasm also associate more abundantly with polyribosomes to inhibit translation and protein synthesis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
Protein_synthesis