| + |
MAPK1 | up-regulates activity 
phosphorylation
|
ELK1 |
0.544 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235459 |
Ser324 |
RDLELPLsPSLLGGP |
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 7889942 |
We demonstrate that elk-1, a protein closely related to p62tcf in function, is a nuclear target of two members of the map kinase family, erk1 and erk2, erk1 phosphorylates five c-terminal sites in elk-1 (s324,t336, s383, s389 and s422) with varying degrees of efficiency. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235455 |
Ser383 |
IHFWSTLsPIAPRSP |
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 7889942 |
We demonstrate that elk-1, a protein closely related to p62tcf in function, is a nuclear target of two members of the map kinase family, erk1 and erk2, erk1 phosphorylates five c-terminal sites in elk-1 (s324,t336, s383, s389 and s422) with varying degrees of efficiency. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235471 |
Ser389 |
LSPIAPRsPAKLSFQ |
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 7889942 |
We demonstrate that elk-1, a protein closely related to p62tcf in function, is a nuclear target of two members of the map kinase family, erk1 and erk2, erki phosphorylates five c-terminal sites in elk-i (s324,t336, s383, s389 and s422) with varying degrees of efficiency. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235463 |
Ser422 |
LSTPVVLsPGPQKP |
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 7889942 |
We demonstrate that elk-1, a protein closely related to p62tcf in function, is a nuclear target of two members of the map kinase family, erk1 and erk2, erki phosphorylates five c-terminal sites in elk-i (s324,t336, s383, s389 and s422) with varying degrees of efficiency. |
|
| Publications: |
4 |
Organism: |
Mus Musculus |
| + |
MAPK3 | up-regulates
phosphorylation
|
ELK1 |
0.582 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-34653 |
Ser324 |
RDLELPLsPSLLGGP |
Homo sapiens |
|
| pmid |
sentence |
| 7889942 |
Erki phosphorylates five c-terminal sites in elk-i (s324, t336, s383, s389 and s422) with varying degrees of efficiency. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-34657 |
Ser383 |
IHFWSTLsPIAPRSP |
Homo sapiens |
|
| pmid |
sentence |
| 7889942 |
Erki phosphorylates five c-terminal sites in elk-i (s324, t336, s383, s389 and s422) with varying degrees of efficiency. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-34661 |
Ser389 |
LSPIAPRsPAKLSFQ |
Homo sapiens |
|
| pmid |
sentence |
| 7889942 |
Erki phosphorylates five c-terminal sites in elk-i (s324, t336, s383, s389 and s422) with varying degrees of efficiency. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-34665 |
Ser422 |
LSTPVVLsPGPQKP |
Homo sapiens |
|
| pmid |
sentence |
| 7889942 |
Erki phosphorylates five c-terminal sites in elk-i (s324, t336, s383, s389 and s422) with varying degrees of efficiency. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-34669 |
Thr336 |
GGPGPERtPGSGSGS |
Homo sapiens |
|
| pmid |
sentence |
| 7889942 |
Erki phosphorylates five c-terminal sites in elk-i (s324, t336, s383, s389 and s422) with varying degrees of efficiency. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-29923 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7618106 |
The tcf protein elk-1 is phosphorylated by the jnk and erk groups of mitogen-activated protein (map) kinases causing increased dna binding, ternary complex formation, and transcriptional activation |
|
| Publications: |
6 |
Organism: |
Homo Sapiens |
| + |
ERK1/2 | up-regulates
phosphorylation
|
ELK1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252085 |
Ser324 |
RDLELPLsPSLLGGP |
Homo sapiens |
|
| pmid |
sentence |
| 7889942 |
Erki phosphorylates five c-terminal sites in elk-i (s324, t336, s383, s389 and s422) with varying degrees of efficiency. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252083 |
Ser383 |
IHFWSTLsPIAPRSP |
Homo sapiens |
|
| pmid |
sentence |
| 7889942 |
Erki phosphorylates five c-terminal sites in elk-i (s324, t336, s383, s389 and s422) with varying degrees of efficiency. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252086 |
Ser389 |
LSPIAPRsPAKLSFQ |
Homo sapiens |
|
| pmid |
sentence |
| 7889942 |
Erki phosphorylates five c-terminal sites in elk-i (s324, t336, s383, s389 and s422) with varying degrees of efficiency. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252084 |
Ser422 |
LSTPVVLsPGPQKP |
Homo sapiens |
|
| pmid |
sentence |
| 7889942 |
Erki phosphorylates five c-terminal sites in elk-i (s324, t336, s383, s389 and s422) with varying degrees of efficiency. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252082 |
Thr336 |
GGPGPERtPGSGSGS |
Homo sapiens |
|
| pmid |
sentence |
| 7889942 |
Erki phosphorylates five c-terminal sites in elk-i (s324, t336, s383, s389 and s422) with varying degrees of efficiency. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252081 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7618106 |
The tcf protein elk-1 is phosphorylated by the jnk and erk groups of mitogen-activated protein (map) kinases causing increased dna binding, ternary complex formation, and transcriptional activation |
|
| Publications: |
6 |
Organism: |
Homo Sapiens |
| Pathways: | EGFR Signaling, Glioblastoma Multiforme, IL6 Signaling, Integrin Signaling, Noonan syndrome |
| + |
RPS6KA5 | up-regulates
phosphorylation
|
ELK1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-85514 |
Ser383 |
IHFWSTLsPIAPRSP |
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 11145955 |
Phosphorylation on ser383 and ser389 of elk-1 by mapk enhances this basal binding but, most importantly, elk-1 exhibits new interactions with p300. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Ovary |
| + |
MAPK14 | up-regulates
phosphorylation
|
ELK1 |
0.505 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-167539 |
Ser383 |
IHFWSTLsPIAPRSP |
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 20727996 |
Elk-1 is a member of the e-twenty-six (ets) domain superfamily of transcription factors and has been traditionally associated with mitogen-induced immediate early gene transcription upon phosphorylation by mitogen activated protein kinases (erk/mapk). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-85510 |
Ser383 |
IHFWSTLsPIAPRSP |
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 11145955 |
Subsequent studies with dominant negative elk-1, wild type, and variant gal4-elk-1 fusion proteins confirmed that phosphorylation of elk-1 at serines 383 and 389 in the c-terminal region of elk-1 is an important downstream target associated with activation of an sre by e2. Both e2 (er?-Dependent) and growth factors (er?-Independent) activated the sre in breast cancer cells via the ras/mapk pathway |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-47630 |
Ser383 |
IHFWSTLsPIAPRSP |
Homo sapiens |
|
| pmid |
sentence |
| 9130707 |
We demonstrate here that elk-1 is barely activated by a third subclass of map kinases (p38), most likely because the critical residues ser383 and ser389 are poorly phosphorylated by p38 map kinase. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-47634 |
Ser389 |
LSPIAPRsPAKLSFQ |
Homo sapiens |
|
| pmid |
sentence |
| 9130707 |
We demonstrate here that elk-1 is barely activated by a third subclass of map kinases (p38), most likely because the critical residues ser383 and ser389 are poorly phosphorylated by p38 map kinase. |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| Tissue: |
Ovary |
| + |
TAOK2 | up-regulates activity
phosphorylation
|
ELK1 |
0.314 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-246638 |
Ser383 |
IHFWSTLsPIAPRSP |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 12665513 |
Transfection studies demonstrated that TAO2 stimulates phosphorylation of the TCF Elk1 on the major activating site, Ser383, and that TAO2 stimulates transactivation of Elk1 and the related TCF, Sap1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK8 | up-regulates
phosphorylation
|
ELK1 |
0.494 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-44356 |
Ser383 |
IHFWSTLsPIAPRSP |
Homo sapiens |
|
| pmid |
sentence |
| 8846788 |
However, both of these stimuli strongly activate two other mapks, jnk1 and jnk2, and stimulate elk-1 transcriptional activity and phosphorylation jnk phosphorylation sites include ser383 and ser389, the major residues whose phosphorylation is responsible for enhancement of elk-1 trascriptional activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | EGFR Signaling, SAPK/JNK Signaling |
| + |
MAPK8 | up-regulates activity
phosphorylation
|
ELK1 |
0.494 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236432 |
Ser389 |
LSPIAPRsPAKLSFQ |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 7651411 |
However, both of these stimuli strongly activate two other mapks, jnk1 and jnk2, and stimulate elk-1 transcriptional activity and phosphorylation jnk phosphorylation sites include ser383 and ser389, the major residues whose phosphorylation is responsible for enhancement of elk-1 trascriptional activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236455 |
Ser389 |
LSPIAPRsPAKLSFQ |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 8846788 |
We find that the JNKs are the predominant Elk-1 activation domain kinases in extracts of UV-irradiated cells and that immunopurified JNK1/2 phosphorylate Elk-1 on the same major sites recognized by ERK1/2, that potentiate its transcriptional activity. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | EGFR Signaling, SAPK/JNK Signaling |
| + |
MAPK9 | up-regulates activity
phosphorylation
|
ELK1 |
0.471 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-247062 |
Ser389 |
LSPIAPRsPAKLSFQ |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 8846788 |
However, both of these stimuli strongly activate two other mapks, jnk1 and jnk2, and stimulate elk-1 transcriptional activity and phosphorylation jnk phosphorylation sites include ser383 and ser389, the major residues whose phosphorylation is responsible for enhancement of elk-1 trascriptional activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK1 | up-regulates
phosphorylation
|
ELK1 |
0.544 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235467 |
Thr336 |
GGPGPERtPGSGSGS |
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 7889942 |
We demonstrate that elk-1, a protein closely related to p62tcf in function, is a nuclear target of two members of the map kinase family, erk1 and erk2, erki phosphorylates five c-terminal sites in elk-i (s324,t336, s383, s389 and s422) with varying degrees of efficiency. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
PRPF4B | up-regulates
phosphorylation
|
ELK1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-77135 |
Thr417 |
ISVDGLStPVVLSPG |
Homo sapiens |
|
| pmid |
sentence |
| 10799319 |
Activated hprp4 phosphorylates residue thr-417 on elk-1 resulting in elk-1 activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Brain, Lung |
| + |
ELK1 | up-regulates quantity by expression
transcriptional regulation
|
PRKCA |
0.417 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256336 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26010542 |
The luciferase reporter assay results revealed that the presence of both MZF-1 and Elk-1 significantly contributed to the upregulation of PKCα gene transcription activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AKT | up-regulates activity
phosphorylation
|
ELK1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259029 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22085529 |
Both mitogen-activated protein kinase (MAPK)/extracellular-signal-regulated kinases (ERK) 1/2 and phosphatidylinositide-3-OH kinase (PI3K)/Akt pathways regulate activation of E-twenty-six (ETS)-like transcription factor 1 (Elk-1) in U138 glioblastoma cells. The phosphatidylinositide-3-OH kinase (PI3K)/Akt pathway was also involved in the Elk-1 activation. Activation of the Elk-1 led to an increased survival and a proliferative response with the EGF stimulation in the U138 glioblastoma cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | EGFR Signaling, Glioblastoma Multiforme, Integrin Signaling |
| + |
Gbeta | up-regulates
phosphorylation
|
ELK1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270075 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7889942 |
Erki phosphorylates five c-terminal sites in elk-i (s324, t336, s383, s389 and s422) with varying degrees of efficiency. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Cullin 1-RBX1-Skp1 | down-regulates quantity by destabilization 
polyubiquitination
|
ELK1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272129 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 23940030 |
The F-box protein FBXO25 promotes the proteasome-dependent degradation of ELK-1 protein. FBXO25 is one of the 69 known human F-box proteins that serve as specificity factors for a family of ubiquitin ligases composed of SKP1, Rbx1, Cullin1, and F-box protein (SCF1) that are involved in targeting proteins for degradation across the ubiquitin proteasome system. FBXO25 interacted with and mediated the ubiquitination and proteasomal degradation of ELK-1 in HEK293T cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HLX | up-regulates quantity by expression
transcriptional regulation
|
ELK1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261622 |
|
|
Homo sapiens |
SGHPL-4 Cell |
| pmid |
sentence |
| 20008130 |
In this study, we have identified cell cycle regulatory genes as downstream targets of the homeobox gene HLX in cultured trophoblast cells, namely RB1, MYC, EGR1, CDKN1C, ELK1, CCNB1, and JUN. RB1 and MYC mRNA expression was increased with HLX inactivation, whereas EGR1, CDKN1C, ELK1, CCNB1, and JUN mRNA expression was decreased compared with mock-transfected control cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ELK1 | up-regulates 
|
Cell_growth |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-233471 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23426362 |
AR required ELK1 to up-regulate a major subset of its target genes that was strongly and primarily enriched for cell growth functions |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | EGFR Signaling, Glioblastoma Multiforme, IL6 Signaling, Integrin Signaling |
| + |
TNFRSF17 | up-regulates
|
ELK1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-79486 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10903733 |
Bcma overexpression activates elk-1 nuclear factor |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ELK1 | up-regulates quantity by expression
transcriptional regulation
|
MUC4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254096 |
|
|
Homo sapiens |
BxPC-3 Cell |
| pmid |
sentence |
| 19757157 |
Through promoter screening, overexpressing methods and luciferase reporter studies, we found that transcription factors CREB, Ets-1, Elk-1 and STAT1 can positively regulate MUC4 expression at the promoter and mRNA level. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FBXO25 | down-regulates quantity by destabilization
binding
|
ELK1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272127 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 23940030 |
The F-box protein FBXO25 promotes the proteasome-dependent degradation of ELK-1 protein. FBXO25 is one of the 69 known human F-box proteins that serve as specificity factors for a family of ubiquitin ligases composed of SKP1, Rbx1, Cullin1, and F-box protein (SCF1) that are involved in targeting proteins for degradation across the ubiquitin proteasome system. FBXO25 interacted with and mediated the ubiquitination and proteasomal degradation of ELK-1 in HEK293T cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ELK1 | up-regulates quantity by expression
transcriptional regulation
|
PRKCA |
0.417 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256282 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16297876 |
We demonstrated that both Elk-1 and MZF-1 were highly expressed in human poor differentiated HCC cells and involved in the up-regulation of PKCa, which was essential for cell migration and invasion. Over-expression assay confirmed that the PKCa expression may be modulated by these two factors at the transcriptional level. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ERK1/2 | up-regulates activity
phosphorylation
|
ELK1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-233520 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23616010 |
Erk also undergoes rapid translocation into the nucleus, where it phosphorylates and activates a variety of transcription factor targets, including sp1, e2f, elk-1, and ap1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | EGFR Signaling, Glioblastoma Multiforme, IL6 Signaling, Integrin Signaling, Noonan syndrome |
| + |
PELI3 | up-regulates
|
ELK1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-103986 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12874243 |
Pellino3 leads to activation of c-jun and elk-1, but not nf-kappab. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
ELK1
- 
- 