Eosinophil: IL5

Pathway ID: SIGNOR-EosIL5

Description: Interleukin-5 (IL5) is the most important maturation and differentiation factors for eosinohpils in humans and mice. It binds to IL-5 receptor alpha, leading to a signaling cascade that involves AKT1 and ERK. This pathway is important for the regulation of genes involved in proliferation and survival of eosinophils.

Curated by: Alessandro Palma

9 Seed Entities

Organism:
Name Primary ID
IL5 P05113
Proliferation SIGNOR-PH4
Differentiation SIGNOR-PH37
AKT SIGNOR-PF24
IL5RA Q01344
STAT5A P42229
ERK1/2 SIGNOR-PF1
JAK2 O60674
AKT1 P31749