Relation Results

Summary

Name IL5
Full Name Interleukin-5
Synonyms IL-5, B-cell differentiation factor I, Eosinophil differentiation factor, T-cell replacing factor, TRF
Primary ID P05113
Links - -
Type protein
Relations 3
Pathways Eosinophil: IL5
Function Factor that induces terminal differentiation of late-developing B-cells to immunoglobulin secreting cells.

Viewer

Type: Score: Layout: SPV 
0.8830.70.399IL5IL5RADegranulationAKT1

Relations

Regulator
Mechanism
target
score
+ up-regulates img/direct-activation.png binding IL5RA 0.883
Identifier Residue Sequence Organism Cell Line
SIGNOR-40039 in vitro
pmid sentence
Single chain and wt il5 also had similar binding affinity for soluble il5 receptor alpha chain, the specificity subunit of the il5 receptor, as measured kinetically with an optical biosensor.
Publications: 1 Organism: In Vitro
+ up-regulates quantity img/indirect-activation.png IL5 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-255346 Homo sapiens Mast Cell
pmid sentence
The array of mediators released by human mast cells is enormous and explains how mast cells can be involved in so many different physiological and pathophysiological functions. Of particular relevance [...] cytokines, such as IL-3 -basophil recruitment and activation-, IL-5 -eosinophil recruitment and activation- and IL-13 -induction of IgE synthesis by B cells.
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png AKT1 0.399
Identifier Residue Sequence Organism Cell Line
SIGNOR-254351 Homo sapiens
pmid sentence
It has been reported that IL-5 family members and selected chemotactic factors can activate the PI3K-Akt pathway in human blood eosinophils
Publications: 1 Organism: Homo Sapiens
a simple tooltip