| + |
IL5RA | up-regulates activity 
phosphorylation
|
JAK2 |
0.585 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254352 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7602114 |
Jak 2 is physically associated with the IL-5b receptor. The binding of IL-5 to its receptor results in tyrosine phosphorylation and activation of Jak 2 tyrosine kinase within 1 to 3 min. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL5 | up-regulates
binding
|
IL5RA |
0.879 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-40039 |
|
|
in vitro |
|
| pmid |
sentence |
| 8567620 |
Single chain and wt il5 also had similar binding affinity for soluble il5 receptor alpha chain, the specificity subunit of the il5 receptor, as measured kinetically with an optical biosensor. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
IL5RA | up-regulates activity
binding
|
SOX4 |
0.429 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-223010 |
|
|
Mus musculus |
Pro-B-lymphocyte |
| pmid |
sentence |
| 11498591 |
Sox4 activation by IL-5R_ appears to be direct, with syntenin functioning as an adaptor molecule. Syntenin mediates IL-5induced Sox4 activation. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
IL5RA | up-regulates 
|
ERK1/2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254350 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21106848 |
Human blood eosinophils exhibit a hyperactive phenotype in response to chemotactic factors after cell priming with IL-5 family cytokines. Earlier work has identified ERK1/2 as molecular markers for IL-5 priming |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
IL5RA
- 
- 