3.0
Fibroblast: Arginine metabolism and collagen synthesis
Pathway ID: SIGNOR-FibroARG
Description: Arginine is a dibasic aminoacid whose metabolism is involved in several important processes, such as the synthesis of NO (nitric oxide), polyamines, and proline, all involved in collagen synthesis and proliferation. Arginase catalyzeS the hydrolysis of arginine to ornithine and urea. Ornithine serves as a substrate for ornithine decarboxylase (ODC), an important enzyme in the synthesis of polyamines. Polyamines are small molecules which regulate several processes, including cell proliferation.
Curated by: Alessandro Palma
Description: Arginine is a dibasic aminoacid whose metabolism is involved in several important processes, such as the synthesis of NO (nitric oxide), polyamines, and proline, all involved in collagen synthesis and proliferation. Arginase catalyzeS the hydrolysis of arginine to ornithine and urea. Ornithine serves as a substrate for ornithine decarboxylase (ODC), an important enzyme in the synthesis of polyamines. Polyamines are small molecules which regulate several processes, including cell proliferation.
Curated by: Alessandro Palma
10 Seed Entities
Organism: 
|
Name | Primary ID |
|---|---|
| L-ornithine | CHEBI:15729 |
| spermine | CHEBI:15746 |
| ECM_synthesis | SIGNOR-PH8 |
| putrescine | CHEBI:17148 |
| OAT | P04181 |
| Proliferation | SIGNOR-PH4 |
| ODC1 | P11926 |
| spermidine | CHEBI:16610 |
| proline | CHEBI:26271 |
| ARG1 | P05089 |