Fibroblast: FN1 transcriptional regulation

Pathway ID: SIGNOR-FibroFN1TR

Description: In muscle regeneration, one fundamental function of fibroblasts and macrophages is the deposition of fibrillar ECM, such as collagen and fibronectin (FN1), and basement membrane constituents that are important for cell movement. FN1 transcription is guided by Snail1, p65NF-κB and PARP1, which interact to activate the expression of fibronectin and other ECM genes.

Curated by: Alessandro Palma

5 Seed Entities

Organism:
Name Primary ID
PARP1 P09874
SNAI1 O95863
SNAIL/RELA/PARP1 SIGNOR-C198
RELA Q04206
FN1 P02751