| + |
FN1 | up-regulates activity 
binding
|
A8/b1 integrin |
0.681 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253304 |
|
|
|
|
| pmid |
sentence |
| 15721307 |
Integrin alpha8beta1-fibronectin interactions promote cell survival via PI3 kinase pathway. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253305 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 7559467 |
The human integrin alpha 8 beta 1 functions as a receptor for tenascin, fibronectin, and vitronectin. |
|
| Publications: |
2 |
Organism: |
, Homo Sapiens |
| + |
SERPINA5 | down-regulates activity 
binding
|
FN1 |
0.315 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265881 |
|
|
Homo sapiens |
Liver Cancer Cell |
| pmid |
sentence |
| 24388360 |
SERPINA5 inhibits HCC cell migration by directly interacting with fibronectin. SERPINA5 disrupts the fibronectin–integrin β1 signaling pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TCF7 | up-regulates quantity by expression
transcriptional regulation
|
FN1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281229 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 40025258 |
Specifically, TCF7 knockdown resulted in decreased levels of N-cadherin, Vimentin, Snail, and Fibronectin 1 (FN1), whereas TCF7 overexpression led to an increase in these proteins (Fig. 3C). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TWIST1 | up-regulates quantity by expression
transcriptional regulation
|
FN1 |
0.414 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281220 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30591455 |
Basic helix-loop-helix transcription factor Twist1 has been described as a master regulator of EMT, repressing the expression of epithelial phenotype markers responsible for cell–cell interaction such as E-cadherin, and at the same time inducing the expression of mesenchymal genes such as Vimentin and Fibronectin, which are involved in cancer cell mobility and invasion |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FN1 | up-regulates 
|
Epithelial-mesenchymal_transition |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281221 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28109697 |
Epithelial-Mesenchymal Transition (EMT) is a dynamic process through which epithelial cells transdifferentiate from an epithelial phenotype into a mesenchymal phenotype.Here we investigate the role of the extracellular matrix (ECM) protein fibronectin (FN) in this process. We demonstrate that inhibition of FN fibrillogenesis blocks activation of the Transforming Growth Factor-Beta (TGF-β) signaling pathway via Smad2 signaling, decreases cell migration and ultimately leads to inhibition of EMT. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281222 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28109697 |
Epithelial-Mesenchymal Transition (EMT) is a dynamic process through which epithelial cells transdifferentiate from an epithelial phenotype into a mesenchymal phenotype.Here we investigate the role of the extracellular matrix (ECM) protein fibronectin (FN) in this process. We demonstrate that inhibition of FN fibrillogenesis blocks activation of the Transforming Growth Factor-Beta (TGF-β) signaling pathway via Smad2 signaling, decreases cell migration and ultimately leads to inhibition of EMT. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
SNAIL/RELA/PARP1 | up-regulates quantity by expression
transcriptional regulation
|
FN1 |
0.412 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254529 |
|
|
Homo sapiens |
Fibroblast, Mesenchymal Cell |
| pmid |
sentence |
| 22223884 |
Taken together, our results indicate that Snail1, p65NF-κB and PARP1 interact to activate the expression of fibronectin and other ECM genes involved in cell movement. This mechanism is functional not only in epithelial cells undergoing EMT but also in fibroblasts. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FN1 | up-regulates
|
MAPK3 |
0.605 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-165350 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20457810 |
We conclude that, by interacting with fibronectin, pref-1 activates integrin downstream signaling to activate mek/erk and to inhibit adipocyte differentiation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FN1 | up-regulates
binding
|
Av/b6 integrin |
0.734 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-19793 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 1532572 |
Integrin alpha v beta 6 binds to fibronectin, but not to vitronectin or collagen i. cell adhesion assays show that fg-2 cell attachment to fibronectin is only partially inhibited by anti-beta 1 integrin antibodies, implying that other fibronectin receptors may be involved. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TWIST1 | up-regulates quantity by expression
transcriptional regulation
|
FN1 |
0.414 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255521 |
|
|
Homo sapiens |
GBM-8401 Cell |
| pmid |
sentence |
| 20646316 |
Individual genes upregulated by TWIST1 known to promote EMT and/or GBM invasion included SNAI2, MMP2, HGF, FAP and FN1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FN1 | form complex 
binding
|
FN1/SDC4 |
0.712 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255285 |
|
|
|
|
| pmid |
sentence |
| 23290138 |
We found that binding of ECM glycoprotein Fibronectin (FN) to Sdc4 stimulates the ability of Wnt7a to induce the symmetric expansion of satellite stem cells |
|
| Publications: |
1 |
| + |
FN1 | up-regulates activity
binding
|
A5/b1 integrin |
0.749 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253250 |
|
|
Homo sapiens |
K-562 Cell |
| pmid |
sentence |
| 12123670 |
We have developed a cell-free assay for binding of solubilized beta1 integrins to their physiologically relevant ligands using an electrochemiluminescent detection method|Binding was clearly optimal for the presumed physiological ligands, i.e., collagen IV for a1b1, collagen I for a2b1, VCAM-Ig for a4b1, fibronectin (the 120-kDa cell attachment fragment was used) for a5b1, and laminin for a6b1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FN1 | up-regulates activity
binding
|
SDC4 |
0.712 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255846 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23290138 |
Sdc4 is a high affinity receptor for fibronectin (FN) […] Therefore, we conclude that Sdc4 binds FN on activated satellite cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FGG | down-regulates activity
binding
|
FN1 |
0.551 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251970 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 2243140 |
Fibrinogen y-chain carboxyterminal (GQQHHLGGAKQAGDV) peptides inhibit fibrinogen, fibronectin (Fn), vitronectin, and von Willebrand factor (vWF) binding to the platelet glycoprotein Ilb-Illa complex (GP lIbII1a). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Vincristine sulfate | down-regulates activity
chemical inhibition
|
FN1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259252 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30599272 |
Vincristine is commonly administered as an effective anti-brain tumor drug. Vincristine treatment also impaired the microtubule-associated protein tubulin, and fibronectin, and downregulated MMP10 activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DLK1 | up-regulates
binding
|
FN1 |
0.373 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-165347 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20457810 |
We show a direct interaction of pref-1 and fibronectin via the pref-1 juxtamembrane domain and fibronectin c-terminal domain |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
FN1
- 
- 