4.0
Galactose metabolism
Pathway ID: SIGNOR-GM
Description: Galactose metabolism mainly occurs in the liver, where galactose is first phosphorylated by galactokinase to form galactose-1-phosphate. Galactose-1-phosphate then reacts with UDP-glucose through the action of galactose-1-phosphate uridylyltransferase (GALT) to produce UDP-galactose and glucose-1-phosphate. UDP-galactose is subsequently converted into UDP-glucose by UDP-galactose 4-epimerase, allowing the cycle to continue. Glucose-1-phosphate is then converted into glucose-6-phosphate, which can enter glycolysis or be used for glycogen synthesis. In this way, galactose is efficiently converted into glucose derivatives that can be used for energy production or storage according to the body’s metabolic needs.
Curated by: Marta Iannuccelli
Use SIGNOR Cytoscape App
Description: Galactose metabolism mainly occurs in the liver, where galactose is first phosphorylated by galactokinase to form galactose-1-phosphate. Galactose-1-phosphate then reacts with UDP-glucose through the action of galactose-1-phosphate uridylyltransferase (GALT) to produce UDP-galactose and glucose-1-phosphate. UDP-galactose is subsequently converted into UDP-glucose by UDP-galactose 4-epimerase, allowing the cycle to continue. Glucose-1-phosphate is then converted into glucose-6-phosphate, which can enter glycolysis or be used for glycogen synthesis. In this way, galactose is efficiently converted into glucose derivatives that can be used for energy production or storage according to the body’s metabolic needs.
Curated by: Marta Iannuccelli
Use SIGNOR Cytoscape App
18 Seed Entities
Organism: 
|
Name | Primary ID |
|---|---|
| UDP-alpha-D-galactose(2-) | CHEBI:66914 |
| alpha-D-glucose 1-phosphate(2-) | CHEBI:58601 |
| galactitol | CHEBI:16813 |
| GALM | Q96C23 |
| beta-D-galactose | CHEBI:27667 |
| Glycolysis | SIGNOR-PH34 |
| α-D-glucose | CHEBI:17925 |
| GALT | P07902 |
| NADP(3-) | CHEBI:58349 |
| alpha-D-galactose | CHEBI:28061 |
| NADPH(4-) | CHEBI:57783 |
| alpha-D-galactose 1-phosphate | CHEBI:17973 |
| AKR1B1 | P15121 |
| alpha-D-glucose 6-phosphate(2-) | CHEBI:58225 |
| GALE | Q14376 |
| GALK1 | P51570 |
| UDP-alpha-D-glucose(2-) | CHEBI:58885 |
| PGM1 | P36871 |