| + |
L-arginine | up-regulates activity 
chemical activation
|
SLC38A9 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254895 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 29053970 |
SLC38A9 mediates the transport, in an arginine-regulated fashion, of many essential amino acids out of lysosomes, including leucine, which mTORC1 senses through the cytosolic Sestrin proteins |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
L-arginine | up-regulates activity 
|
mTORC1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268018 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 27126896 |
Importantly, asparagine/glutamine pre-load only results in mTOR activation following amino acid stimulation (Fig. 5a), indicating that it is their exchange factor roles that elicit mTORC1 activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
L-arginine | up-regulates
|
ARG1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255555 |
|
|
|
Macrophage |
| pmid |
sentence |
| 25386178 |
In mammalian cells, arginine can be catabolized by four classes of enzymes (Figure (Figure1):1): NOS, arginase, arginine decarboxylase (ADC), and arginine:glycine amidinotransferase (AGAT) |
|
| Publications: |
1 |
| Tissue: |
Skeletal Muscle |
| + |
L-arginine | up-regulates
|
NOS2 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255554 |
|
|
|
Macrophage |
| pmid |
sentence |
| 25386178 |
In mammalian cells, arginine can be catabolized by four classes of enzymes (Figure (Figure1):1): NOS, arginase, arginine decarboxylase (ADC), and arginine:glycine amidinotransferase (AGAT) |
|
| Publications: |
1 |
| Tissue: |
Skeletal Muscle |
3.0
L-arginine
