| + |
17beta-estradiol | up-regulates quantity 
precursor of
|
estrone |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268662 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16166196 |
A novel 17beta-hydroxysteroid dehydrogenase (17beta-HSD) chronologically named type 12 17beta-HSD (17beta-HSD12), that transforms estrone (E1) into estradiol (E2) was identified by sequence similarity with type 3 17beta-HSD (17beta-HSD3) that catalyzes the formation of testosterone from androstenedione in the testis. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269757 |
|
|
in vitro |
|
| pmid |
sentence |
| 8994190 |
Human 17 beta-hydroxysteroid dehydrogenase (17-HSD) type 1 catalyzes the conversion of the low activity estrogen, estrone, into highly active estradiol, both in the gonads and in target tissues. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269761 |
|
|
in vitro |
|
| pmid |
sentence |
| 8099587 |
17 beta-HSD type 2 was capable of catalyzing the interconversion of testosterone and androstenedione as well as estradiol and estrone. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens, In Vitro |
| Tissue: |
Zona Reticulata |
| Pathways: | Sex Hormone Biosynthesis |
| + |
HSD17B2 | up-regulates quantity
chemical modification
|
estrone |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269762 |
|
|
in vitro |
|
| pmid |
sentence |
| 8099587 |
17 beta-HSD type 2 was capable of catalyzing the interconversion of testosterone and androstenedione as well as estradiol and estrone. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
estrone | up-regulates activity
chemical activation
|
ESR2 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258583 |
|
|
in vitro |
|
| pmid |
sentence |
| 9048584 |
In total 37 substances were tested for both ER subtypes (Fig. 3 and Table 1). In Fig. 3 several examples of typical competitor curves obtained are shown. In all cases monophasic curves were obtained for compounds with significant affinity. . The present study is the first in which the ligand binding properties of both ER subtypes are measured separately, and caution is needed when comparing RBAs from this study with the previous studies involving mixtures of ER subtypes. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
androst-4-ene-3,17-dione | up-regulates quantity
precursor of
|
estrone |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268668 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27702664 |
The cytochrome P450 aromatase is involved in the last step of sex hormones biosynthesis by converting androgens into estrogens. |Human aromatase (CYP19A1) is a membrane-bound class II cytochrome P450 that converts androgens into estrogens [1], [2], [3], [4]. Specifically, the enzyme is involved sex hormones biosynthesis where it is responsible for the conversion of androstenedione, testosterone and 16alpha-hydroxytestosterone into estrone, estradiol and estriol, respectively |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Ovary |
| Pathways: | Sex Hormone Biosynthesis |
| + |
estrone | up-regulates activity
chemical activation
|
ESR1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258584 |
|
|
in vitro |
|
| pmid |
sentence |
| 9048584 |
In total 37 substances were tested for both ER subtypes (Fig. 3 and Table 1). In Fig. 3 several examples of typical competitor curves obtained are shown. In all cases monophasic curves were obtained for compounds with significant affinity. . The present study is the first in which the ligand binding properties of both ER subtypes are measured separately, and caution is needed when comparing RBAs from this study with the previous studies involving mixtures of ER subtypes. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
CYP19A1 | up-regulates quantity
chemical modification
|
estrone |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268670 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27702664 |
The cytochrome P450 aromatase is involved in the last step of sex hormones biosynthesis by converting androgens into estrogens. |Human aromatase (CYP19A1) is a membrane-bound class II cytochrome P450 that converts androgens into estrogens [1], [2], [3], [4]. Specifically, the enzyme is involved sex hormones biosynthesis where it is responsible for the conversion of androstenedione, testosterone and 16alpha-hydroxytestosterone into estrone, estradiol and estriol, respectively |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Ovary |
| Pathways: | Sex Hormone Biosynthesis |
| + |
HSD17B11 | up-regulates quantity
chemical modification
|
estrone |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268663 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16166196 |
A novel 17beta-hydroxysteroid dehydrogenase (17beta-HSD) chronologically named type 12 17beta-HSD (17beta-HSD12), that transforms estrone (E1) into estradiol (E2) was identified by sequence similarity with type 3 17beta-HSD (17beta-HSD3) that catalyzes the formation of testosterone from androstenedione in the testis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Zona Reticulata |
| Pathways: | Sex Hormone Biosynthesis |
| + |
estrone | up-regulates quantity
precursor of
|
17beta-estradiol |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269759 |
|
|
in vitro |
|
| pmid |
sentence |
| 8994190 |
Human 17 beta-hydroxysteroid dehydrogenase (17-HSD) type 1 catalyzes the conversion of the low activity estrogen, estrone, into highly active estradiol, both in the gonads and in target tissues. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269763 |
|
|
in vitro |
|
| pmid |
sentence |
| 8099587 |
17 beta-HSD type 2 was capable of catalyzing the interconversion of testosterone and androstenedione as well as estradiol and estrone. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268661 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16166196 |
A novel 17beta-hydroxysteroid dehydrogenase (17beta-HSD) chronologically named type 12 17beta-HSD (17beta-HSD12), that transforms estrone (E1) into estradiol (E2) was identified by sequence similarity with type 3 17beta-HSD (17beta-HSD3) that catalyzes the formation of testosterone from androstenedione in the testis. |
|
| Publications: |
3 |
Organism: |
In Vitro, Homo Sapiens |
| Tissue: |
Zona Reticulata |
| Pathways: | Sex Hormone Biosynthesis |
| + |
HSD17B1 | up-regulates quantity
chemical modification
|
estrone |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269758 |
|
|
in vitro |
|
| pmid |
sentence |
| 8994190 |
Human 17 beta-hydroxysteroid dehydrogenase (17-HSD) type 1 catalyzes the conversion of the low activity estrogen, estrone, into highly active estradiol, both in the gonads and in target tissues. |
|
| Publications: |
1 |
Organism: |
In Vitro |
3.0
estrone