| + |
CERT1 | up-regulates quantity 
relocalization
|
ceramide |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268496 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18184806 |
In mammalian cells, ceramide is synthesized in the endoplasmic reticulum and transferred to the Golgi apparatus for conversion to sphingomyelin. Ceramide transport occurs in a nonvesicular manner and is mediated by CERT, a cytosolic 68-kDa protein with a C-terminal steroidogenic acute regulatory protein-related lipid transfer (START) domain. The CERT START domain efficiently transfers natural D-erythro-C16-ceramide, but not lipids with longer (C20) amide-acyl chains. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CERS5 | up-regulates quantity
chemical modification
|
ceramide |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273996 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26887952 |
Ceramides in mammals vary greatly in their acyl-chain composition: six different ceramide synthase isozymes (CERS1-6) that exhibit distinct substrate specificity and tissue distribution account for this diversity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CERS1 | up-regulates quantity
chemical modification
|
ceramide |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273993 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26887952 |
Ceramides in mammals vary greatly in their acyl-chain composition: six different ceramide synthase isozymes (CERS1-6) that exhibit distinct substrate specificity and tissue distribution account for this diversity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ceramide | up-regulates quantity
precursor of
|
sphingomyelin |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268497 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18184806 |
Ceramide is a common precursor for both sphingomyelin and glycosphingolipids, which are ubiquitous components of membranes in mammalian cells and play important roles in cell growth, differentiation, and apoptosis |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CERK | down-regulates quantity 
chemical modification
|
ceramide |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268500 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 34202192 |
Another relevant enzyme is Ceramide kinase (CerK), which phosphorylates Cer to produce Ceramide 1-phosphate (C1P). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ceramide | up-regulates quantity
precursor of
|
ceramide 1-phosphate(2-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268501 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 34202192 |
Another relevant enzyme is Ceramide kinase (CerK), which phosphorylates Cer to produce Ceramide 1-phosphate (C1P). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ceramide | up-regulates quantity
precursor of
|
glycosphingolipid |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268498 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18184806 |
Ceramide is a common precursor for both sphingomyelin and glycosphingolipids, which are ubiquitous components of membranes in mammalian cells and play important roles in cell growth, differentiation, and apoptosis |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CERS6 | up-regulates quantity
chemical modification
|
ceramide |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273997 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26887952 |
Ceramides in mammals vary greatly in their acyl-chain composition: six different ceramide synthase isozymes (CERS1-6) that exhibit distinct substrate specificity and tissue distribution account for this diversity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CERS2 | up-regulates quantity
chemical modification
|
ceramide |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273994 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26887952 |
Ceramides in mammals vary greatly in their acyl-chain composition: six different ceramide synthase isozymes (CERS1-6) that exhibit distinct substrate specificity and tissue distribution account for this diversity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CERS4 | up-regulates quantity
chemical modification
|
ceramide |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273998 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26887952 |
Ceramides in mammals vary greatly in their acyl-chain composition: six different ceramide synthase isozymes (CERS1-6) that exhibit distinct substrate specificity and tissue distribution account for this diversity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CERS3 | up-regulates quantity
chemical modification
|
ceramide |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273995 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26887952 |
Ceramides in mammals vary greatly in their acyl-chain composition: six different ceramide synthase isozymes (CERS1-6) that exhibit distinct substrate specificity and tissue distribution account for this diversity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
ceramide