+ |
MTR | down-regulates quantity
chemical modification
|
(6S)-5-methyltetrahydrofolate(2-) |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-253144 |
|
|
Homo sapiens |
|
pmid |
sentence |
10520212 |
Methionine synthase is a vitamin B12-dependent enzyme that catalyses the remethylation of homocysteine to methionine. Therefore, defects in this enzyme may result in elevated homocysteine levels. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Pathways: | One-carbon Metabolism |
+ |
FOLR1 | up-regulates quantity
relocalization
|
(6S)-5-methyltetrahydrofolate(2-) |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-268267 |
|
|
Homo sapiens |
|
pmid |
sentence |
10787414 |
The differential polarized distribution of the reduced-folate transporter (RFT-1) and folate receptor alpha (FRalpha), the two proteins involved in the transport of folate, has been characterized in normal mouse retinal pigment epithelium (RPE) and in cultured human RPE cells. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
SLC19A1 | up-regulates quantity
relocalization
|
(6S)-5-methyltetrahydrofolate(2-) |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-268266 |
|
|
Homo sapiens |
|
pmid |
sentence |
10787414 |
The differential polarized distribution of the reduced-folate transporter (RFT-1) and folate receptor alpha (FRalpha), the two proteins involved in the transport of folate, has been characterized in normal mouse retinal pigment epithelium (RPE) and in cultured human RPE cells. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
(6S)-5-methyltetrahydrofolate(2-) | up-regulates quantity
precursor of
|
methionine |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-253141 |
|
|
Homo sapiens |
|
pmid |
sentence |
10720211 |
Methylenetetrahydrofolate reductase (MTHFR) plays a central role in the folate cycle and contributes to the metabolism of the amino acid homocysteine. It catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, thus generating the active form of folate required for remethylation of homocysteine to methionine. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Pathways: | One-carbon Metabolism |
+ |
(6R)-5,10-methylenetetrahydrofolate(2-) | up-regulates quantity
precursor of
|
(6S)-5-methyltetrahydrofolate(2-) |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-268230 |
|
|
Homo sapiens |
|
pmid |
sentence |
10720211 |
Methylenetetrahydrofolate reductase (MTHFR) plays a central role in the folate cycle and contributes to the metabolism of the amino acid homocysteine. It catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, thus generating the active form of folate required for remethylation of homocysteine to methionine. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Pathways: | One-carbon Metabolism |
+ |
MTHFR | up-regulates quantity
chemical modification
|
(6S)-5-methyltetrahydrofolate(2-) |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-268229 |
|
|
Homo sapiens |
|
pmid |
sentence |
10720211 |
Methylenetetrahydrofolate reductase (MTHFR) plays a central role in the folate cycle and contributes to the metabolism of the amino acid homocysteine. It catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, thus generating the active form of folate required for remethylation of homocysteine to methionine. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Pathways: | One-carbon Metabolism |